Common drugs causing allergy in patients attending a tertiary care centre in South Kerala

Shameem N., Krishna Kumar M. K.


Background: Drugs play an important part in the wellbeing of human life. Adverse drug reactions are also a part of drug administration. Adverse drug reactions mainly manifest in the form of skin lesions such as urticaria or maculo-papular rash. Drug allergy is a common clinical problem and its assessment is important for appropriate management of the condition. Diagnosis of drug allergy relies on a careful history and in some instance’s allergy testing may be required.  Aim was to determine the common drugs causing allergy.

Methods: After obtaining informed written consent, data was entered in a schedule and an intradermal test was done in the volar aspect of the patient’s forearm with the selected list of twenty-four drugs.

Results: The maximum number of study subjects showed positive reactions were for ampicillin, paracetamol, diclofenac and ketorolac.

Conclusions: The drugs which are commonly used by the medical practitioners were found to be more allergic to the study subjects.



Drug, Adverse drug reaction, Allergy, Intradermal test

Full Text:



KD Tripathi. Adverse drug effects. In: KD Tripathi. Essentials of medical pharmacology. 7th ed. New Delhi: Jaypee brothers’ medical publishers (p) ltd; 2013: 82.

Khan DA, Solensky R. Drug allergy. J Allergy Clin Immunol. 2010;125:126–37.

Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. J Am Med Assoc. 1998;279(15):1200–5.

Gandhi TK, Weingart SN, Borus J, Seger AC, Peterson J, Burdick E, et al. Adverse drug events in ambulatory care. N Engl J Med. 2003;348(16):1556–64.

Anderson JA. Allergic reactions to drugs and biological agents. J Am Med Assoc. 1992;20:2845-57.

Motosue MS, Bellolio MF, Van Houten HK, Shah ND, Campbell RL. Risk factors for severe anaphylaxis in the United States. Ann Allergy Asthma Immunol. 2017;119(4):356e361.e2.

Grabenhenrich LB, Dolle S, Moneret-Vautrin A, et al. Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. J Allergy Clin Immunol. 2016;137(4):1128e1137.

Rajan A, Ramani PT, Raj S. A study on pattern of adverse drug reaction in an adverse drug reaction monitoring centre of a tertiary care hospital in South Kerala, India. Int J Basic Clin Pharmacol. 2019;8(8):1813-8.

Gaur S, Paramjeet S, Srivastava B, Bhardwaj R, Ahuja S, Gunjita B. Evaluation of adverse drug reactions in teaching hospital in Kumaon region. J Med Sci Clinic Res. 2016;4:12139-45.

Patel TK, Thakkar SH, Sharma D. Cutaneous adverse drug reactions in Indian population: A systematic review. Indian Dermatol Online J. 2014;5(Suppl 2):S76-86.

Suh DC, Woodall BS, Shin SK, Hermes-De Santis ER. Clinical and economic impact of adverse drug reactions in hospitalized patients. Ann Pharmacother. 2000;34(12):1373-9.

Sharma S, Jayakumar D, Palappalli DS. Pharmacovigilance of cutaneous adverse drug reactions among patients attending dermatology department at a Tertiary Care Hospital. Indian Dermatol Online J. 2019;10:547-54.