DOI: https://dx.doi.org/10.18203/2394-6040.ijcmph20222206
Published: 2022-08-26

Prevalence of glucose-6-phosphate dehydrogenase deficiency in newly diagnosed HIV patients: a hospital-based cross-sectional study

Chirantan Majumdar, Sourav Sarkar, Shaoli Ghosh, Bhushan Dattatray Kamble

Abstract


Background: The prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency is 8.5% in India. G6PD deficient individual have different outcomes with certain drugs and result in unexpected events that could be even fatal. HIV affected individuals with G6PD deficient have inherently worse outcomes when they start on those drugs that precipitate the condition. We aimed to study the level of G6PD and its deficiency status among the newly diagnosed HIV patients.

Methods: A cross-sectional study among the newly diagnosed HIV patients was conducted at a tertiary hospital, Kolkata. All the eligible participants (n=100) were recruited consecutively after obtaining the consent. The details on socio-demography, clinical history and investigations were extracted from them. The data were analysed using the appropriate statistical methods.

Results: Out of 100 newly HIV diagnosed participants, the prevalence of G6PD deficiency was 12% (95% CI: 5.6- 18.3%). Participants belonging to tribal population, with familial history of haemolytic disease, history of haemolysis, and increased LDH levels were significantly associated with the deficient G6PD levels among the study participants. Conclusions: The prevalence of G6PD deficiency was high among the newly diagnosed HIV study population. Tribal population and familial history of haemolytic disorders had high number of deficiency and need to be screened for better clinical care.


Keywords


Human immuno-deficiency virus, Hospital, Tertiary care, Glucose-6-phosphate dehydrogenase deficiency

Full Text:

PDF

References


Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis. 2009;42:267-78.

Beutler E. G6PD deficiency. Blood. 1994;84:3613-36.

Cappellini MD, Fiorelli GE. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;37160073:2.

Tungsiripat M, Drechsler H, Sarlone C, Amyot K, Laffey E. Aberg J. Prevalence and significance of G6PD deficiency in patients of an urban clinic. J Int Assoc Physicians AIDS Care. 2008;4:88-90.

Serpa JA, Villareal-Williams E, Giordano TP. Prevalence of G6PD deficiency in a large cohort of HIV-infected patients. J Infect. 2010;61:399-402.

Aukrust P, Muüller F, Svardal AM, Ueland T, Berge RK, Frøland SS. J Infect Dis. 2003;188:232-8.

Feily A, Namazi MR: Glucose-6-phosphate-dehydrogenase deficiency may impart susceptibility to the development of AIDS. Arch Med Res. 2011;42:77.

Herzenberg LA, De Rosa SC, Dubs JG. Glutathione deficiency is associated with impaired survival in HIV disease. Proceed Nat Acad Sci. 1997;94:1967-72.

Pace GW, Leaf CD: The role of oxidative stress in HIV disease. Free Rad Biol Med. 1995;19:523-8.

Rapezzi D, Porqueddu EM, Fenu L. Survival of people who are HIV-1-positive and G6PD-deficient is unaffected by virus-induced oxidative stress. Lancet. 1998;351:264-5.

Staal FJ, Ela SW. Glutathione deficiency and human immunodeficiency virus infection. Lancet. 1992;339:909-12.

Zur Wiesch JS, Wichmann D, Hofer A, van Lunzen J, Burchard GD, Schmiedel S. Primary HIV infection presenting as haemolytic crisis in a patient with previously undiagnosed glucose 6-phosphate dehydrogenase deficiency. AIDS. 2008;22:1886-8.

Kumar P, Yadav U, Rai V. Prevalence of glucose-6-phosphate dehydrogenase deficiency in India: an updated meta-analysis. Egypt J Med Human Genet. 2016;17:295-302.

Mukherjee S. Prevalence of glucose 6 phosphate dehydrogenase deficiency in Eastern India, a Study from. 2017;2:31-5.

Xu JZ, Francis RO, Nadal LE. G6PD deficiency in an HIV clinic setting in the Dominican Republic. Am J Trop Med Hyg. 2015;93:722-9.

Aneke JC, Ibeh NC, Okocha CE, Orakpor E. Evaluation of glucose-6- phosphate dehydrogenase enzyme deficiency and methemoglobin concentration in blood donors in a Nigerian Tertiary hospital-based blood bank. Global J Transfus Med. 2017;2:137.

Mukherjee MB, Colah RB, Martin S, Ghosh K. Glucose-6-phosphate dehydrogenase (G6PD) deficiency among tribal populations of India-Country scenario. Indian J Med Res. 2015;141:516.

Peters AL, Noorden CJ. Glucose-6-phosphate dehydrogenase deficiency and malaria: cytochemical detection of heterozygous G6PD deficiency in women. J Histochem Cytochem. 2009;57:1003-11.

Shanthala DA, Chaithra V, Karuna R. Screening for G6PD deficiency in blood donor population. Indian J Hematol Blood Transfusion. 2010;26:122-3.