Prevalence of glucose-6-phosphate dehydrogenase deficiency in newly diagnosed HIV patients: a hospital-based cross-sectional study
Keywords:Human immuno-deficiency virus, Hospital, Tertiary care, Glucose-6-phosphate dehydrogenase deficiency
Background: The prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency is 8.5% in India. G6PD deficient individual have different outcomes with certain drugs and result in unexpected events that could be even fatal. HIV affected individuals with G6PD deficient have inherently worse outcomes when they start on those drugs that precipitate the condition. We aimed to study the level of G6PD and its deficiency status among the newly diagnosed HIV patients.
Methods: A cross-sectional study among the newly diagnosed HIV patients was conducted at a tertiary hospital, Kolkata. All the eligible participants (n=100) were recruited consecutively after obtaining the consent. The details on socio-demography, clinical history and investigations were extracted from them. The data were analysed using the appropriate statistical methods.
Results: Out of 100 newly HIV diagnosed participants, the prevalence of G6PD deficiency was 12% (95% CI: 5.6- 18.3%). Participants belonging to tribal population, with familial history of haemolytic disease, history of haemolysis, and increased LDH levels were significantly associated with the deficient G6PD levels among the study participants. Conclusions: The prevalence of G6PD deficiency was high among the newly diagnosed HIV study population. Tribal population and familial history of haemolytic disorders had high number of deficiency and need to be screened for better clinical care.
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