Email this article A case of measles in a Nepalese child: where are we failing?
Abstract
Measles affected more than 90% of children under 15 years of age and caused 2-3 million measles-associated deaths globally each year before the introduction of vaccines against it. Today, measles vestiges a leading cause of vaccine-preventable illness worldwide, causing more than 100,000 deaths annually. Characterized by a febrile rash illness, measles is often self-resolving. However, significant complications can occur including encephalitis with permanent neurologic sequelae and death in one to three out of 1000 measles cases. Although global measles elimination is a WHO goal, current trends in the epidemiology of measles and vaccine hesitancy suggest that this goal is not yet attainable. As the most highly transmissible vaccine-preventable disease, measles is especially subtle to changes in herd immunity, the impact of vaccine refusal and globalization.
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Paules CI, Marston HD, Fauci AS. Measles in 2019 going backward. N Engl J Med. 2019; 380:2185-7.
Hayman DTS. Measles vaccination in an increasingly immunized and developed world. Hum Vacc Immunother. 2019;15:28-33.
Graham M, Winter AK, Ferrari M. Measles and the canonical path to elimination. Science. 2019;364:584-7.
Feemster KA, Szipszky C. Resurgence of measles in the United States: how did we get here? Curr Opin Pediatr. 2020;32(1):139-44.
Gao Y, Kc A, Chen C, Huang Y, Wang Y, Zou S, Zhou H. Inequality in measles vaccination coverage in the "big six" countries of the WHO South-East Asia region. Hum Vaccin Immunother. 2020;16(7):1485-97.
Patel MK, Dumolard L, Nedelec Y, Sodha SV, Steulet C, Gacic-Dobo M, et al. Progress toward regional measles elimination Worldwide, 2000-2018. MMWR. 2019;68(48):1105-11.
WHO South-East Asia regional immunization technical advisory group. Available at: WHO South-East Asia Regional Immunization Technical Advisory Group (SEAR-ITAG): Report of the Ninth Meeting. Accessed on 20 September 2021.
Hyle EP, Fields NF, Fiebelkorn AP. The clinical impact and cost & effectiveness of measles mumps rubella vaccination to prevent measles importations among international travelers from the United States. Clin Infect Dis. 2019;69:306-15.
