Epidemiology, etiology, and treatment of denture stomatitis


  • Meisan Ali Bukhari North Jeddah Specialist Dental Center, King Abdullah Medical Complex, Jeddah, Saudi Arabia
  • Mashael Abdullah Algahtani Taif Specialized Dental Center, Ministry of Health, Taif, Saudi Arabia
  • Faisal Abdullah Alsuwailem College of Dentistry, King Saud University, Riyadh, Saudi Arabia
  • Rakan Mishaal Alogaiel College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • Safa Hejji Almubarak Ministry of Health, Turaif, Saudi Arabia
  • Saud Salman Alqahtani College of Dentistry, King Faisal University, Hofuf, Saudi Arabia
  • Raghdah Abdulaziz Alabdullatif Primary Healthcare Center, Ministry of Health, Buraydah, Saudi Arabia
  • Reem Yaqoub Alghimlas College of Dentistry, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia
  • Noura Fahad Alotaibi General Dentist, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
  • Atheer Rakkad Al Qahtani College of Dentistry, Vision Colleges, Riyadh, Saudi Arabia
  • Norah Khaled Alkathiri College of Dentistry, Vision Colleges, Riyadh, Saudi Arabia




Denture stomatitis, Candida albicans, Oral infection, Prosthesis


Multiple factors are involved in the pathogenesis of denture stomatitis, which increases the risk of tissue infection and inflammation. These factors include poor oral hygiene, trauma secondary to poorly fitting prostheses, resin porosity, and bacterial plaque accumulation. Our present review discusses the epidemiology, etiology, and treatment of denture stomatitis based on data from current studies in the literature. The prevalence of denture stomatitis is significantly variable among the different studies, as previously discussed. However, the cumulative incidence of denture stomatitis among their participants ranged between 17-77%. These hugely variable rates have been attributed to the nature of data collection, diagnostic criteria, sample size, and patient demographics. Studies also show that the condition is more prevalent among elderly females. However, not many studies have reported this correlation, indicating the need for future studies. Candida albicans infection is the primary parameter in the etiology and pathogenesis of the condition. However, other factors related to the patient (like status of immunological response) and dentures (like hygiene) were also reported. Therefore, the management of denture stomatitis should be based on applying adequate interventions. Besides, using antifungal medications is also necessary to eradicate organism.


Cubera K. Denture stomatitis-definition, etiology, classification and treatment. Przeglad lekarski. 2013;70(11):947-9.

Dhamande MM, Pakhan AJ, Thombare RU, Ghodpage SL. Evaluation of efficacy of commercial denture cleansing agents to reduce the fungal biofilm activity from heat polymerized denture acrylic resin: An in vitro study. Contemporary clinical dentistry. 2012;3(2):168-72.

Hong G, Murata H, Li Y, Sadamori S, Hamada T. Influence of denture cleansers on the color stability of three types of denture base acrylic resin. J prosthetic dentistry. 2009;101(3):205-13.

Altarawneh S, Bencharit S, Mendoza L. Clinical and histological findings of denture stomatitis as related to intraoral colonization patterns of Candida albicans, salivary flow, and dry mouth. Journal of prosthodontics : official journal of the American College of Prosthodontists. 2013;22(1):13-22.

Aoun G, Berberi A. Prevalence of Chronic Erythematous Candidiasis in Lebanese Denture Wearers: a Clinico-microbiological Study. Materia socio-medica. 2017;29(1):26-9.

Byrd WC, Schwartz-Baxter S, Carlson J, Barros S, Offenbacher S, Bencharit S. Role of salivary and candidal proteins in denture stomatitis: an exploratory proteomic analysis. Molecular bioSystems. 2014;10(9):2299-304.

Moosazadeh M, Akbari M, Tabrizi R. Denture Stomatitis and Candida albicans in Iranian Population: A Systematic Review and Meta-Analysis. J dentistry (Shiraz, Iran). 2016;17(3):283-92.

Kovac-Kovacic M, Skaleric U. The prevalence of oral mucosal lesions in a population in Ljubljana, Slovenia. J oral pathol. 2000;29(7):331-5.

García-Pola Vallejo MJ, Martínez Díaz-Canel AI, García Martín JM, González García M. Risk factors for oral soft tissue lesions in an adult Spanish population. Community dentistry oral epidemiol. 2002;30(4):277-85.

Mumcu G, Cimilli H, Sur H, Hayran O, Atalay T. Prevalence and distribution of oral lesions: a cross-sectional study in Turkey. Oral diseases. 2005;11(2):81-87.

Budtz-Jörgensen E, Stenderup A, Grabowski M. An epidemiologic study of yeasts in elderly denture wearers. Community dentistry and oral epidemiol. 1975;3(3):115-9.

Nevalainen MJ, Närhi TO, Ainamo A. Oral mucosal lesions and oral hygiene habits in the home-living elderly. J oral rehabilitation. 1997;24(5):332-7.

Mikkonen M, Nyyssönen V, Paunio I, Rajala M. Oral hygiene, dental visits and age of denture for prevalence of denture stomatitis. Community dentistry oral epidemiol. 1984;12(6):402-5.

Reichart PA. Oral mucosal lesions in a representative cross-sectional study of aging Germans. Community dentistry oral epidemiol. 2000;28(5):390-8.

Vigild M. Oral mucosal lesions among institutionalized elderly in Denmark. Community dentistry and oral epidemiology. 1987;15(6):309-13.

Freitas JB, Gomez RS, De Abreu MH, Ferreira EFE. Relationship between the use of full dentures and mucosal alterations among elderly Brazilians. J oral rehabilitation. 2008;35(5):370-4.

Espinoza I, Rojas R, Aranda W, Gamonal J. Prevalence of oral mucosal lesions in elderly people in Santiago, Chile. J oral pathol med. 2003;32(10):571-5.

Gendreau L, Loewy ZG. Epidemiology and Etiology of Denture Stomatitis. J Prosthodontics. 2011;20(4):251-60.

Aoun G, Cassia A. Evaluation of denture-related factors predisposing to denture stomatitis in a lebanese population. Materia socio-medica. 2016;28(5):392-6.

MacPhail LA, Komaroff E, Alves ME, Navazesh M, Phelan JA, Redford M. Differences in risk factors among clinical types of oral candidiasis in the Women's Interagency HIV Study. Oral surg oral med oral pathol oral radiol endodontics. 2002;93(1):45-55.

McMullan-Vogel CG, Jüde HD, Ollert MW, Vogel CW. Serotype distribution and secretory acid proteinase activity of Candida albicans isolated from the oral mucosa of patients with denture stomatitis. Oral microbiol immunol. 1999;14(3):183-9.

Carvalho de Oliveira T, Frigerio M, Yamada M, Birman E. Evaluation of denture stomatitis in users of complete dentures. Pesquisa Odontológica Brasileira. 2000;14:219-24.

Coco BJ, Bagg J, Cross LJ, Jose A, Cross J, Ramage G. Mixed Candida albicans and Candida glabrata populations associated with the pathogenesis of denture stomatitis. Oral microbiol immunol. 2008;23(5):377-83.

Frenkel H, Harvey I, Newcombe RG. Oral health care among nursing home residents in Avon. Gerodontology. 2000;17(1):33-8.

Baran I, Nalçacı R. Self-reported denture hygiene habits and oral tissue conditions of complete denture wearers. Arch gerontol geriatrics. 2009;49(2):237-41.

Vasconcelos LCD, Vasconcelos LCDS, Ghersel ELDA, Veloso DJ, Cunha Pâsmda. Denture hygiene: importance in denture stomatitis control. RGO Revista Gaúcha de Odontologia. 2013;61(2):255-61.

Martins K, Gontijo S. Treatment of denture stomatitis: literature review. Revistas. 2017;74:215.

Aoun G, Saadeh M, Berberi A. Effectiveness of Hexetidine 0.1% Compared to Chlorhexidine Digluconate 0.12% in Eliminating Candida albicans Colonizing Dentures: A Randomized Clinical In Vivo Study. J int oral health. 2015;7(8):5-8.

Sutula J, Coulthwaite L, Thomas L, Verran J. The effect of a commercial probiotic drink on oral microbiota in healthy complete denture wearers. Microbial ecol health disease. 2012;23.

Cross LJ, Williams DW, Sweeney CP, Jackson MS, Lewis MA, Bagg J. Evaluation of the recurrence of denture stomatitis and Candida colonization in a small group of patients who received itraconazole. Oral surg oral med oral pathol oral radiol endodontics. 2004;97(3):351-8.

Cross LJ, Bagg J, Wray D, Aitchison T. A comparison of fluconazole and itraconazole in the management of denture stomatitis: a pilot study. J dentistry. 1998;26(8):657-64.

Arruda CNF, Salles MM, Badaró MM. Effect of sodium hypochlorite and Ricinus communis solutions on control of denture biofilm: A randomized crossover clinical trial. J prosthetic dentistry. 2017;117(6):729-34.

Yousef M, Abdelaziz A, Essa M, Fahmi M. Assessment of Photodynamic Therapy and Miconazole in the Management of Denture Stomatitis. Assessment of Photodynamic Therapy and Miconazole in the Management of Denture Stomatitis. 2018;83-7.

Martins KV, De Lacerda Gontijo SM. Treatment of denture stomatitis: literature review. Rev Bras Odontol. 2017;74(3):215-20.

Milillo L, Muzio LL, Carlino P, Serpico R, Coccia E, Scully C. Candida-related denture stomatitis: a pilot study of the efficacy of an amorolfine antifungal varnish. Int J Prosthodontics. 2005;18:1.

Budtz-Jørgensen E, Holmstrup P, Krogh P. Fluconazole in the treatment of Candida-associated denture stomatitis. Antimicrobial agents chemother. 1988;32(12):1859-63.

Martin-Mazuelos E, Aller AI, Romero MJ, et al. Response to fluconazole and itraconazole of Candida spp. in denture stomatitis. Mycoses. 1997;40(7-8):283-9.

Cross LJ, Bagg J, Aitchison TC. Efficacy of the cyclodextrin liquid preparation of itraconazole in treatment of denture stomatitis: comparison with itraconazole capsules. Antimicrobial agents chemother. 2000;44(2):425-7.

Friccius H, Pohla H, Adibzadeh M, Siegels-Hübenthal P, Schenk A, Pawelec G. The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells. Int j immunopharmacol. 1992;14(5):791-9.

Al-Shayyab MH, Abu-Hammad OA, Al-Omiri MK, Dar-Odeh NS. Antifungal prescribing pattern and attitude towards the treatment of oral candidiasis among dentists in Jordan. Int dental j. 2015;65(4):216-6.

Nairn RI. Nystatin and amphotericin B in the treatment of denture-related candidiasis. Oral surg oral med and oral pathol. 1975;40(1):68-75.

Falah-Tafti A, Jafari AA, Lotfi-Kamran MH, Fallahzadeh H, Hayan RS. A Comparison of the eFficacy of Nystatin and Fluconazole Incorporated into Tissue Conditioner on the In Vitro Attachment and Colonization of Candida albicans. Dental res j. 2010;7(1):18-22.

Geerts GA, Stuhlinger ME, Basson NJ. Effect of an antifungal denture liner on the saliva yeast count in patients with denture stomatitis: a pilot study. J oral rehabilitation. 2008;35(9):664-9.

Mahdavi Omran S, Rezaei Dastjerdi M, Zuashkiani M, Moqarabzadeh V, Taghizadeh-Armaki M. In Vitro Antifungal Susceptibility of Candida species Isolated from Iranian Patients with Denture Stomatitis. BioMed research int. 2018;2018:3086586.

Khozeimeh F, Shahtalebi MA, Noori M, Savabi O. Comparative evaluation of ketoconazole tablet and topical ketoconazole 2% in orabase in treatment of Candida-infected denture stomatitis. J Contemp Dent Pract. 2010;11(2):017-24.

Kadir T, Gümrü B, Uygun-Can B. Phospholipase activity of Candida albicans isolates from patients with denture stomatitis: the influence of chlorhexidine gluconate on phospholipase production. Arch oral biol. 2007;52(7):691-6.

Maciel CM, Piva MR, Ribeiro MA, De Santana Santos T, Ribeiro CF, Martins-Filho PR. Methylene Blue-Mediated Photodynamic Inactivation Followed by Low-Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis. J prosthodontics. 2016;25(1):28-32.

De Figueiredo Freitas LS, Rossoni RD, Jorge AOC, Junqueira JC. Repeated applications of photodynamic therapy on Candida glabrata biofilms formed in acrylic resin polymerized. Lasers med sci. 2017;32(3):549-55.

Mima EG, Pavarina AC, Ribeiro DG, Dovigo LN, Vergani CE, Bagnato VS. Effectiveness of photodynamic therapy for the inactivation of Candida spp. on dentures: in vitro study. Photomedicine laser surg. 2011;29(12):827-33.

Acosta-Torres LS, Mendieta I, Nuñez-Anita RE, Cajero-Juárez M, Castaño VM. Cytocompatible antifungal acrylic resin containing silver nanoparticles for dentures. Int j nanomed. 2012;7:4777-86.




How to Cite

Bukhari, M. A., Algahtani, M. A., Alsuwailem, F. A., Alogaiel, R. M., Almubarak, S. H., Alqahtani, S. S., Alabdullatif, R. A., Alghimlas, R. Y., Alotaibi, N. F., Qahtani, A. R. A., & Alkathiri, N. K. (2022). Epidemiology, etiology, and treatment of denture stomatitis. International Journal Of Community Medicine And Public Health, 9(2), 981–986. https://doi.org/10.18203/2394-6040.ijcmph20220003



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