Safety and efficacy of pediatric liver transplantation in Saudi Arabia

Ashraf Saeed Mehder; Roaa Abdullah Saati; Linah Abdulrahman Alhamdani; Wadah Kamal Qari; Rawan Mohammad Alqurashi; Shahad Sameer Alkidaiwi; Arwa Ayash Alsubhi; Ashwaq Dakhel Alosaimi; Anfal Jameel Alsharif; Amna Ali Bahareth

doi:10.18203/2394-6040.ijcmph20220082

Authors

Ashraf Saeed Mehder Department of Pediatrics, Al Aziziyah Children Hospital, Jeddah, Saudi Arabia
Roaa Abdullah Saati College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Linah Abdulrahman Alhamdani College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Wadah Kamal Qari College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Rawan Mohammad Alqurashi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Shahad Sameer Alkidaiwi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Arwa Ayash Alsubhi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Ashwaq Dakhel Alosaimi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Anfal Jameel Alsharif College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
Amna Ali Bahareth College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20220082

Keywords:

Pediatrics, Children, Liver transplantation, Safety, Complications, Efficacy

Abstract

Evidence shows that liver transplantation is a good management choice for pediatric patients with severe hepatic disorders. In addition, the approach can be used for managing different hepatic disorders, including metabolic and familial ones. Therefore, liver transplantation is indicated and should be urgently conducted to intervene against further deterioration in the health status of the affected patients and enhance their prognosis. Various investigations in the literature validated the efficacy of the modality for different age groups, although many of them reported the incidence of different related complications. In Saudi Arabia, not many studies reported the safety and efficacy of liver transplantation for pediatric patients. The present literature review provided insight regarding the safety and efficacy of the procedure for this population group. We can conclude that liver transplantation in pediatric settings is a safe and productive approach that can be successfully conducted with a favorable prognosis. Moreover, it has been shown that living-related liver transplantation is more favorable than cadaveric-related liver transplantation in these settings, especially when there is a graft shortage, as reported in Saudi Arabia. Despite the favorable outcomes, further reports are still needed for validating the current evidence.

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