Safety and efficacy of pediatric liver transplantation in Saudi Arabia


  • Ashraf Saeed Mehder Department of Pediatrics, Al Aziziyah Children Hospital, Jeddah, Saudi Arabia
  • Roaa Abdullah Saati College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Linah Abdulrahman Alhamdani College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Wadah Kamal Qari College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Rawan Mohammad Alqurashi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Shahad Sameer Alkidaiwi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Arwa Ayash Alsubhi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Ashwaq Dakhel Alosaimi College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Anfal Jameel Alsharif College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Amna Ali Bahareth College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia



Pediatrics, Children, Liver transplantation, Safety, Complications, Efficacy


Evidence shows that liver transplantation is a good management choice for pediatric patients with severe hepatic disorders. In addition, the approach can be used for managing different hepatic disorders, including metabolic and familial ones. Therefore, liver transplantation is indicated and should be urgently conducted to intervene against further deterioration in the health status of the affected patients and enhance their prognosis. Various investigations in the literature validated the efficacy of the modality for different age groups, although many of them reported the incidence of different related complications. In Saudi Arabia, not many studies reported the safety and efficacy of liver transplantation for pediatric patients. The present literature review provided insight regarding the safety and efficacy of the procedure for this population group. We can conclude that liver transplantation in pediatric settings is a safe and productive approach that can be successfully conducted with a favorable prognosis. Moreover, it has been shown that living-related liver transplantation is more favorable than cadaveric-related liver transplantation in these settings, especially when there is a graft shortage, as reported in Saudi Arabia. Despite the favorable outcomes, further reports are still needed for validating the current evidence.


Dhawan A, Cheeseman P, Mieli-Vergani G. Approaches to acute liver failure in children. Pediatric Transplantation. 2004;8(6):584-8.

Ciocca M, Ramonet M, Cuarterolo M, López S, Cernadas C, Alvarez F. Prognostic factors in paediatric acute liver failure. Arch Disease Childhood. 2008;93(1):48-51.

Cochran JB, Losek JD. Acute liver failure in children. Pediatric Emergency Care. 2007;23(2):129-35.

Al Sebayel M, Abaalkhail F, Hashim A. Living donor liver transplant versus cadaveric liver transplant survival in relation to model for end-stage liver disease score. Transplantation Proceedings. 2015;47(4):1211-3.

Jain A, Singhal A, Kashyap R, Safadjou S, Ryan CK, Orloff MS. Comparative analysis of hepatitis C recurrence and fibrosis progression between deceased-donor and living-donor liver transplantation: 8-year longitudinal follow-up. Transplantation. 2011;92(4):453-60.

Al Sebayel MS, Ramirez CB, Abou Ella K. The first 100 liver transplants in Saudi Arabia. Transplantation Proceedings. 2001;33(5):2709.

Jawdat M, Qattan N, Bassas A, Al Karawi MA, Mohamed E, Khallil H. The first liver transplant in Saudi Arabia and the Arab world. Hepato-gastroenterology. 1993;40(3):297-300.

Jawdat M, Qattan N, al Karawi M, Mohamed AE, Khalil H. The first liver transplant in Saudi Arabia and the Arab world. Transplantation. 1992;54(4):766-7.

Al Sebayel M, Kizilisik A, Ramirez C. Liver transplantation at king fahad national guard hospital riyadh, kingdom of saudi arabia. Saudi J Kidney Dis Transplantation. 1996;7(2):173.

Pham TS, Reda A, Ngan Nguyen TT. Blood exchange transfusion in viral hepatitis in a small infant: a case report. Transfusion Apheresis Sci. 2020;59(6):102907.

Wiesner RH, McDiarmid SV, Kamath PS. MELD and PELD: application of survival models to liver allocation. Liver Transplantation. 2001;7(7):567-80.

Al-Judaibi B, Almaghrabi R, Alghamdi M. Saudi association for the study of liver diseases and transplantation position statement on liver transplantation during the COVID-19 pandemic. Saudi J Gastroenterol. 2020;26(5):233-9.

Son PT, Reda A, Viet DC. Exchange transfusion in the management of critical pertussis in young infants: a case series. Vox sanguinis. 2021;116(9):976-82.

Thieu H, Bach Dat B, Nam NH. Antibiotic resistance of Helicobacter pylori infection in a children's hospital in Vietnam: prevalence and associated factors. Minerva Medica. 2020;111(5):498-501.

Fayyad A, Shagrani M, AlGoufi T. Progress and outcomes of the first high-volume pediatric liver transplantation program in Saudi Arabia. Clinical Transplants. 2014:77-83.

Khan I, Al-Shaqrani M, Arain Z, Al-Hebbi H, Wali S, Bassas A. One hundred and thirty-seven living donor pediatric liver transplants at Riyadh Military Hospital Results and outlook for future. Saudi Med J. 2009;30:403-8.

Holdar S, Alsaleem B, Asery A, Al-Hussaini A. Outcome of biliary atresia among Saudi children: A tertiary care center experience. Saudi J Gastroenterol. 2019;25(3):176-80.

Al-Sebayel M, Khalaf H, Al-Sofayan M. Experience with 122 consecutive liver transplant procedures at King Faisal Specialist Hospital and Research Center. Ann Saudi Med. 2007;27(5):333-8.

Bassas AF, Chehab MS, Al-Shahed MS. Pediatric living-related liver transplantation in Saudi Arabia. Saudi Med J. 2002;23(6):640-4.

El-Qushayri AE, Ghozy S, Reda A, Kamel AMA, Abbas AS, Dmytriw AA. The impact of Parkinson's disease on manifestations and outcomes of Covid-19 patients: A systematic review and meta-analysis. Reviews Med Virol. 2021:e2278.

El-Qushayri AE, Dahy A, Reda A. A closer look to the high burden of the psychiatric disorders among health care workers (HCWs) in Egypt during COVID-19 outbreak: A meta-analysis of 3137 HCWs. Epidemiol Health. 2021:e2021045.

Marcos A, Ham JM, Fisher RA, Olzinski AT, Posner MP. Single-center analysis of the first 40 adult-to-adult living donor liver transplants using the right lobe. Liver Transplantation. 2000;6(3):296-301.

Neuberger J. Incidence, timing, and risk factors for acute and chronic rejection. Liver Transplantation Surgery. 1999;5(4-1):S30-6.

Révillon Y, Michel JL, Lacaille F. Living-related liver transplantation in children: the 'Parisian' strategy to safely increase organ availability. J Pediatr Surg. 1999;34(5):851-3.

Malagó M, Rogiers X, Wadström J, Burdelski M, Broelsch CE. Optimal clinical regimens for living related liver transplantation. Transplantation Proceedings. 1994;26(5):2665-8.

Emond JC, Renz JF, Ferrell LD. Functional analysis of grafts from living donors. Implications for the treatment of older recipients. Anna Surg. 1996;224(4):544-52.

Al-Shurafa H, Jawdat M, Wali S. Donor experience and outcome of pediatric living-related liver transplantation in Saudi Arabia. J Hepato-biliary-pancreatic Surgery. 2003;10(6):428-31.

Reichert PR, Renz JF, Rosenthal P. Biliary complications of reduced-organ liver transplantation. Liver Transplantation Surg. 1998;4(5):343-9.

Dibas M, Doheim MF, Ghozy S, Ros MH, El-Helw GO, Reda A. Incidence and survival rates and trends of skull Base chondrosarcoma: A Population-Based study. Clin Neurol Neurosurg. 2020;198:106153.

Wang G, Zhang Y, Zhao J, Zhang J, Jiang F. Mitigate the effects of home confinement on children during the COVID-19 outbreak. The Lancet. 2020;395(10228):945-7.

Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19? J Microbiol. 2020;53(3):371-2.

Behrman RE, Kliegman RM, Jenson HB. Nelson Textbook of Pediatrics. Arch Dis Childhood. 1945;40:338-8.

D'Antiga L. Coronaviruses and Immunosuppressed Patients: The Facts During the Third Epidemic. Liver Transplantation. 2020;26(6):832-4.




How to Cite

Mehder, A. S., Saati, R. A., Alhamdani, L. A., Qari, W. K., Alqurashi, R. M., Alkidaiwi, S. S., Alsubhi, A. A., Alosaimi, A. D., Alsharif, A. J., & Bahareth, A. A. (2022). Safety and efficacy of pediatric liver transplantation in Saudi Arabia. International Journal Of Community Medicine And Public Health, 9(2), 964–968.



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