DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20214799

Immunological and physiological responses related to orthodontic treatment

Rehab Fuad Bawyan, Ahmed Jamil Baajajah, Haitham Abdullah Alzahrani, Mohammed Abdulkader Murad, Hattan Mohammed Hisham Jamalellail, Sarah Yousef Muthaffar, Abdulaziz Abdulrahim Alandijani, Mohammed Abdulrhman Khayat, Abdulrahman Ahmed Bahurmoz, Abdulrahman Talal Azab, Majed Abdullah Almalki

Abstract


Orthodontic treatment is usually approached to achieve better aesthetics by influencing tooth movement in different positions within the jaw. The application of mechanical forces during the process of treatment is the main responsible for these events. Remarkable changes in the vascularity of the underlying tissues were also reported to occur secondary to applying orthodontic forces. This significantly leads to the synthesis and release of many metabolites and signaling molecules. Furthermore, it might be associated with various immunological and physiological responses that enhance or deteriorate the prognosis. Therefore, the present study reviewed the literature to identify the different immunological and physiological responses secondary to orthodontic treatment. Our findings indicate that different immune cells and immunoglobulins are usually involved in orthodontic treatment-related events. Moreover, we found that cytokines and chemokines have an important role in the post-treatment inflammatory process, leading to bone resorption or bone formation. Various cytokines were reported in this context, including TNF-α, IFN-γ, IL-13, IL-12, IL-8, IL-6, and IL-1β. The roles of these modalities have been discussed based on their effects on bone remodeling following orthodontic treatment.


Keywords


Inflammation, Immunological, Physiological, Orthodontic, Treatment

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References


Grant F. Anesthetic considerations in the multiple endocrine neoplasia syndromes. Curr Opin Anaesthesiol. 2005;18(3):345-52.

Asiry MA. Biological aspects of orthodontic tooth movement: A review of literature. Saudi J Biol Sci. 2018;25(6):1027-32.

Nayak BN, Galil KA, Wiltshire W, Lekic PC. Molecular Biology of Orthodontic Tooth Movement. J Oral Health Dentist. 2013;1:101-6.

Krishnan V, Davidovitch Z. Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop. 2006;129(4):469-72.

Kumar AA, Saravanan K, Kohila K, Kumar SS. Biomarkers in orthodontic tooth movement. J Pharm Bioallied Sci. 2015;7(2):325-30.

Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 10th ed. Elsevier Health: Netherland; 2021.

Norevall LI, Forsgren S, Matsson L. Expression of neuropeptides (CGRP, substance P) during and after orthodontic tooth movement in the rat. Eur J Orthod. 1995;17(4):311-25.

Kvinnsland I, Kvinnsland S. Changes in CGRP-immunoreactive nerve fibres during experimental tooth movement in rats. Eur J Orthod. 1990;12(3):320-9.

Haug SR, Brudvik P, Fristad I, Heyeraas KJ. Sympathectomy causes increased root resorption after orthodontic tooth movement in rats: immunohistochemical study. Cell Tissue Res. 2003;313(2):167-75.

Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 2007;7(4):292-304.

Freitas MR, Beltrão RT, Janson G, Henriques JF, Chiqueto K. Evaluation of root resorption after open bite treatment with and without extractions. Am J Orthod Dentofacial Orthop. 2007;132(2):143-22.

Hidalgo MM, Itano EN, Consolaro A. Humoral immune response of patients with dental trauma and consequent replacement resorption. Dent Traumatol. 2005;21(4):218-21.

Son PT, Reda A, Viet DC, Quynh NXT, Hung DT, Tung TH, et al. Exchange transfusion in the management of critical pertussis in young infants: a case series. Vox Sang. 2021;116(9):976-82.

Youness SR, Hussein JS, Refaat WES, Hazem MI, Hariri EM. Effect of Orthodontic Treatment on Salivary Immunoglobulin A Levels among a group of healthy Egyptian Children. IOSR J Dental Med Sci. 2015;14(4):58-63.

Marcotte H, Lavoie MC. Oral microbial ecology and the role of salivary immunoglobulin A. Microbiol Mol Biol Rev. 1998;62(1):71-109.

Taha A. The correlation between root resorption and some immune parameters in well-controlled type Ι diabetic patients during orthodontic treatment. J Dent Sci. 2015;96-104.

Jacobsen N, Pettersen A. Changes in occupational health problems and adverse patient reactions in orthodontics from 1987 to 2000. Eur J Orthod. 2003;25(6):591-8.

Ramos SP, Ortolan GO, Dos SLM, Tobouti PL, Hidalgo MM, Consolaro A, et al. Anti-dentine antibodies with root resorption during orthodontic treatment. Eur J Orthod. 2011;33(5):584-91.

Nguyen TM, Huan VT, Reda A, Morsy S, Nam Giang HT, Tri VD, et al. Clinical features and outcomes of neonatal dengue at the Children's Hospital 1, Ho Chi Minh, Vietnam. J Clin Virol. 2021;138:104758.

Yan Y, Liu F, Kou X, Liu D, Yang R, Wang X, et al. T Cells Are Required for Orthodontic Tooth Movement. J Dent Res. 2015;94(10):1463-70.

Ren Y, Maltha JC, Jagtman AM. Optimum force magnitude for orthodontic tooth movement: a systematic literature review. Angle Orthod. 2003;73(1):86-92.

Dibas M, Doheim MF, Ghozy S, Ros MH, Helw GO, Reda A. Incidence and survival rates and trends of skull Base chondrosarcoma: A Population-Based study. Clin Neurol Neurosurg. 2020;198:106153.

Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. CD40-CD40L expression during orthodontic tooth movement in rats. Angle Orthod. 2004;74(1):100-5.

Baba S, Kuroda N, Arai C, Nakamura Y, Sato T. Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement. Arch Oral Biol. 2011;56(5):466-73.

Maltha JC, Krishnan V, Jagtman AM. Cellular and Molecular Biology of Orthodontic Tooth Movement. Biological Mechanisms of Tooth Movement. 3rd ed. Wiley: USA; 2021: 33-48.

Qushayri AE, Ghozy S, Reda A, Kamel AMA, Abbas AS, Dmytriw AA. The impact of Parkinson's disease on manifestations and outcomes of Covid-19 patients: A systematic review and meta-analysis. Rev Med Virol. 2021:2278.

Lo YJ, Liu CM, Wong MY, Hou LT, Chang WK. Interleukin 1beta-secreting cells in inflamed gingival tissue of adult periodontitis patients. Cytokine. 1999;11(8):626-33.

Qushayri AE, Dahy A, Reda A, Mahmoud MA, Mageed SA, Kamel AMA, et al. A closer look at the high burden of psychiatric disorders among healthcare workers in Egypt during the COVID-19 pandemic. Epidemiol Health. 2021;43:2021045.

Taddei SR, Andrade I, Junior CM, Garlet TP, Garlet GP, Cunha FQ, et al. Role of CCR2 in orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2012;141(2):153-60.

Alansari S, Sangsuwon C, Vongthongleur T. Biological principles behind accelerated tooth movement. Seminars Orthodont. 2015;21:151-61.

Ghurabi B, Hindawi S, Mohammed I. Physiological role of immune system elements in orthodontic treatment. Biochem Cell Arch. 2020:6767-72.

Andrade I, Taddei SRA, Souza PEA. Inflammation and Tooth Movement: The Role of Cytokines, Chemokines, and Growth Factors. Sem Orthodont. 2012;18(4):257-69.

Vujacic, Pavlovic J, Ristic AK. The Role of Cytokines in Orthodontic Tooth Movement. Current Approach Orthodont. 2018.

Yamamoto T, Kita M, Oseko F, Nakamura T, Imanishi J, Kanamura N. Cytokine production in human periodontal ligament cells stimulated with Porphyromonas gingivalis. J Periodontal Res. 2006;41(6):554-9.

Garlet TP, Coelho U, Silva JS, Garlet GP. Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans. European J Oral Sci. 2007;115(5):355-62.

Teixeira CC, Khoo E, Tran J, Chartres I, Liu Y, Thant LM, et al. Cytokine expression and accelerated tooth movement. J Dent Res. 2010;89(10):1135-41.

Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 2008;473(2):139-46.

Li Y, Jacox LA, Little SH, Ko CC. Orthodontic tooth movement: The biology and clinical implications. Kaohsiung J Med Sci. 2018;34(4):207-14.

Jovčić MN, Vujačić A, Konić A, Pavlović J, Todorović V, Glibetić M. The role of cytokines in orthodontic tooth movement. Srp Arh Celok Lek. 2012;140(5):371-8.

Uematsu S, Mogi M, Deguchi T. Interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, epidermal growth factor, and beta 2-microglobulin levels are elevated in gingival crevicular fluid during human orthodontic tooth movement. J Dent Res. 1996;75(1):562-7.

Ren Y, Vissink A. Cytokines in crevicular fluid and orthodontic tooth movement. Eur J Oral Sci. 2008;116(2):89-97.

Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, et al. IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions. Immunol Lett. 2011;137(1):53-61.