Immunological and physiological responses related to orthodontic treatment

Authors

  • Rehab Fuad Bawyan Department of Orthodontics, King Fahad General Hospital, Jeddah, Saudi Arabia
  • Ahmed Jamil Baajajah Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Haitham Abdullah Alzahrani Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Mohammed Abdulkader Murad Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Hattan Mohammed Hisham Jamalellail Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Sarah Yousef Muthaffar Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Abdulaziz Abdulrahim Alandijani Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Mohammed Abdulrhman Khayat General Dentist, Ministry of Health, Hail, Saudi Arabia
  • Abdulrahman Ahmed Bahurmoz Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Abdulrahman Talal Azab Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
  • Majed Abdullah Almalki Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20214799

Keywords:

Inflammation, Immunological, Physiological, Orthodontic, Treatment

Abstract

Orthodontic treatment is usually approached to achieve better aesthetics by influencing tooth movement in different positions within the jaw. The application of mechanical forces during the process of treatment is the main responsible for these events. Remarkable changes in the vascularity of the underlying tissues were also reported to occur secondary to applying orthodontic forces. This significantly leads to the synthesis and release of many metabolites and signaling molecules. Furthermore, it might be associated with various immunological and physiological responses that enhance or deteriorate the prognosis. Therefore, the present study reviewed the literature to identify the different immunological and physiological responses secondary to orthodontic treatment. Our findings indicate that different immune cells and immunoglobulins are usually involved in orthodontic treatment-related events. Moreover, we found that cytokines and chemokines have an important role in the post-treatment inflammatory process, leading to bone resorption or bone formation. Various cytokines were reported in this context, including TNF-α, IFN-γ, IL-13, IL-12, IL-8, IL-6, and IL-1β. The roles of these modalities have been discussed based on their effects on bone remodeling following orthodontic treatment.

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Published

2021-12-27

How to Cite

Bawyan, R. F., Baajajah, A. J., Alzahrani, H. A., Murad, M. A., Jamalellail, H. M. H., Muthaffar, S. Y., Alandijani, A. A., Khayat, M. A., Bahurmoz, A. A., Azab, A. T., & Almalki, M. A. (2021). Immunological and physiological responses related to orthodontic treatment. International Journal Of Community Medicine And Public Health, 9(1), 394–398. https://doi.org/10.18203/2394-6040.ijcmph20214799

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Section

Review Articles