Pre-operative immunomodulatory nutrition and post-operative outcomes of surgical treatment of gastrointestinal surgery: a systematic review

Authors

  • Hisham Abdullah Almottowa Department of General Surgery, King Fahad General Hospital, Jeddah, Saudi Arabia
  • Ahmed Salman Al-Khars Department of Emergency Medicine, Abqaiq General Hospital, Abqaiq, Saudi Arabia
  • Maan Almotaz Kurdi College of Medicine, Masaryk University, Brno, Czechia
  • Ahmed Kamal Almusawi College of Medicine, Medical University of Warsaw, Warsaw, Poland
  • Amr Rashad Hakeem Department of Anaesthesia, King Abdulaziz Hospital, Jeddah, Saudi Arabia
  • Nada Ahmad Almashat Department of Anaesthesia, 7College of Medicine, King Abdulaziz Hospital, Jeddah, Saudi Arabia
  • Abdulaziz Wajdi Jowharji College of Medicine, King Abdulaziz Hospital, Jeddah, Saudi Arabia
  • Turki Salem Aljaza Department of Anaesthesia, King Khalid Hospital, Hail, Saudi Arabia
  • Mohammad Ismail Bukhary College of Medicine, King Abdulaziz Hospital, Jeddah, Saudi Arabia
  • Hussain Oamr Almahmudi Department of General Surgery, South Qunfudha Hospital, Qunfudha, Saudi Arabia
  • Mased Ali Alsaeidi Department of General Surgery, Jahra Hospital, Jahra, Kuwait

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20214619

Keywords:

Malnutrition, Immunomodulatory nutrition, Gastrointestinal tumors, Gastric cancer, Colorectal carcinoma, Glutamine, Arginine, Omega-3

Abstract

Malnutrition is a major health problem in cancer evident in up to 80% of patients. It was associated with high mortality and morbidity, especially with surgical treatment of cancer. That is why many studies are investigating efficient treatment for this problem. One of these treatments is immunomodulatory nutrition. Immunomodulatory nutrition has shown efficacy towards malnutrition, immune status, and other comorbidities. However, there is still a debate about whether it is efficient or not. Five databases were searched using specific search terms. We only included randomized controlled trials that studied the efficacy of preoperative immunomodulatory nutrition before surgical treatment of gastrointestinal carcinoma. The studies were assessed for the quality of evidence. Twenty-three studies were included for the systematic review. Most studies had a low risk of bias. We assessed the efficacy of immunomodulatory nutrition regarding immune markers, infectious complications, non-infectious complications, biological markers, the length of stay, and mortality. Immunomodulatory nutrition has significantly enhanced immune status, biological markers, and post-operative complications. However, it does not have a significant improvement in the mortality rate or hospitalization duration. The immunomodulatory nutrition has promising results in enhancing immune status, and biological markers. However, its effect on post-operative infectious and non-infectious complications is still under debate. Immunomodulatory nutrition had no effect on mortality rates among cancer patients.

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Published

2021-11-24

How to Cite

Almottowa, H. A., Al-Khars, A. S., Kurdi, M. A., Almusawi, A. K., Hakeem, A. R., Almashat, N. A., Jowharji, A. W., Aljaza, T. S., Bukhary, M. I., Almahmudi, H. O., & Alsaeidi, M. A. (2021). Pre-operative immunomodulatory nutrition and post-operative outcomes of surgical treatment of gastrointestinal surgery: a systematic review. International Journal Of Community Medicine And Public Health, 8(12), 6143–6154. https://doi.org/10.18203/2394-6040.ijcmph20214619

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Section

Review Articles