Second wave of COVID-19: more hype than reality

Rajiva Rajiva, Muruganantham Mahalingam, Thumabalabeedu Basavaraj, Maninder Pal Singh Pardal, Aaditya Saxena, Sridhar Chary, Sandeep Singh Mahar


Background: The second wave of COVID-19 hit India with the nation reporting over 4 lakh cases daily since second week of April 2021. Keeping in view the lack of adequate data in this regard; and the public health importance of the second wave of the Covid-19 pandemic, the researchers proceeded to carry out the study.  The aim of the study was  to  study  the clinicoepidemiolgical profile of hospitalised COVID19 cases in an urban area.

Methods: The workers carried out a cross sectional descriptive study. Period of the study was April 2021 to September 2021. Detailed epidemiological, clinical, laboratory and radiological data was obtained in respect of 149 cases of Covid-19.

Results: Mean age of the cases was 39.79 years. One hundred and twelve (75.17%) cases were males, while thirty- seven (24.83%) were females. One hundred and twenty-nine (86.57%) gave history of fever. Eight (6.04%) cases were totally asymptomatic. Clinical condition of six (4.02%) cases necessitated them to be placed on ventilator for various periods of time. Eight (5.36%) cases were administered oxygen for various periods of time. All the cases recovered after varying periods of time; and there were no fatalities. Diabetes mellitus was the commonest comorbidity; and it was seen in twenty (13.42%) of cases.

Conclusions: Our study has indicated that symptomatology of the disease may vary over time. The researchers believe that the most important conclusion of our work is that the world must remain alert to the characteristics of the virus and the disease. 


Clinico epidemiological, COVID-19, SARS-CoV- 2, Second wave

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Zhang H, Shang W, Liu Q, Zheng XZM, Yue M. Clinical characteristics of 194 cases of COVID‑19 in Huanggang and Taian, China. Infection. 2020;12:14-8.

Rodriguez-Moralesa AJ, Cardona-Ospinaa JA, Gutiérrez-Ocampoa E, Villamizar-Peñaa R, Holguin-Riveraa Y, Escalera-Antezanai JP, Alvarado-Arnezi LE et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Medicine and Infectious Disease. 2020;34(2020): 101623.

Li H, Liu Z, Ge J. Scientific research progress of COVID-19/SARS-CoV-2 in the first five months. J Cell Mol Med. 2020;00:1-13.

Sheervalilou R, Shirvaliloo M, Dadashzadeh N, Shirvalilou S, Shahraki O, Pilehvar‐Soltanahmadi Y et al. COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease. J Cell Physiol. 2020;1-52.

Hsih WH, Cheng MY, Ho MW, Chou CH, Lin PC, Chi CY et al. Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan. Journal of Microbiology, Immunology and Infection. 2020;2020(53):459e466.

Wang D, Yin Y, Hu C, Liu X, Zhang X, Zhou S et al. Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China. Critical Care. 2020;2020(24):188.

Rajiva, Muruganantham M, Mukherjee G, Singh PMP, Saxena A, Chary S et al. Clinico-epidemiological profile of COVID-19 cases: Our experiences. J Med Sci Res. 2021;9(3):155-61.

Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. European Radiology. 2020;4:124-8.

Huang X, Wei F, Hu L, Wen L, Chen K. Epidemiology and Clinical Characteristics of COVID-19. Arch Iran Med. 2020;23(4):268-271.

Hussein O. Second wave of Covid-19 is determined by immune mechanism. Medical Hypotheses. 2020;144(2020):110238.

Bontempi E. The europe second wave of COVID-19 infection and the Italy “strange” situation. Environmental Research. 2021;193(2021):110476.

Diaz RS, Vergara TRC. The COVID-19 second wave: A perspective to be explored. Editorial. Braz J Dis. 2021;2 5(1):101537.

Malhotra S, Rahi M, Das P, Chaturvedi R, Chhibber-Goel J, Anvikar A et al. Epidemiological profiles and associated risk factors of SARS-CoV-2 positive patients based on a high-throughput testing facility in India. Open Biol. 2020;11:90-4.

Revised guidelines for Home Isolation of very mild/pre-symptomatic COVID-19 cases. Available at: es10May2020.pdf. Accessed on 20 June 2021.

Balacchi C, Brandi N, Ciccarese F, Coppola F, Lucidi V, Bartalena L et al. Comparing the first and the second waves of COVID‑19 in Italy: differences in epidemiological features and CT findings using a semi‑quantitative score. Emergency Radiology. 2020;7:20-5.

Kumar G, Mukherjee A, Sharma RK, Menon RG, Sahu D, Wig N et al. Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study. Indian Journal Of Medical Research. Available at:;type=0. Accessed on 20 June 2021.

Nonaka CKV, Gräf T, C Barcia AL, Costa VF, J Lopes de Oliveira, Passos RH et al. SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021. International Journal of Infectious Diseases. 2021;111(2021):47-54.

Sen M, Honavar SG, Bansal R, Sengupta S, Rao R, Kim U, et al. Epidemiology, clinical profile, management, and outcome of COVID-19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India – Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC), Report 1. Indian J Ophthalmol 2021;69:1670-92.

Vuong NM, Quyen NTL, Tra DT, Thanh DV, Tuan NQ, Co DX et al. The second wave of COVID-19 in a tourist hotspot in Vietnam Running head: Second wave of COVID-19 in Vietnam. International Society of Travel Medicine. 2020;11:19-21.

Contou D, Fraissé M, Pajot O, T Jo‑Anna, Mentec H, Plantefève G. Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave? Crit Care. 2021;2021:25:3.

Krajcar N, Marić SL, Šurina A, Filipović SK, Trkulja V, Roglić S et al. Epidemiological and clinical features of Croatian children and adolescents with a PCR- confirmed coronavirus disease 2019: differences between the first and second epidemic wave. Croat Med J. 2020;61:491-500.

Iftimie S, Lo´pez-Azcona AF, Vallverdu I, Herna´ndez- Flix S, Gabriel de Febrer, Parra S et al. First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain. PLoS ONE. 2020;16(3):e0248029.

Brehm TT, Heyer A, Roedl K, Jarczak D, Nierhaus A, Nentwich MF et al. Patient Characteristics and Clinical Course of COVID-19 Patients Treated at a German Tertiary Center during the First and Second Waves in the Year 2020. J Clin Med. 2021;10:2274.

Mughal MS, Kaur IP, Wang C, Alhashemi R, Buemio A, Patton CD et al. Variation in clinical characteristics, outcomes, and mortality of hospitalized patients with COVID-19 during the second wave of the pandemic: a single-center experience. J Investig Med. 2020;11:22-8.

Natale DG, Natale LD, Troise C, Marchitelli V, Coviello A, Holmberg KG et al. The Evolution of Covid-19 in Italy after the Spring of 2020: An Unpredicted Summer Respite Followed by a Second Wave. Int J Environ Res Public Health. 2020;17:8708.

Goodman JR. An evolving crisis. New Scientist. 2020;41-5.

Newey S. Could Sars-Cov-2 be evolving to become more transmissible – but less lethal? Available at: Accessed on 20 June 2021.