Published: 2021-11-24

Demographic variables and clinical profile of scrub typhus patients: experience from a tertiary care center in Udaipur, Rajasthan

Suresh Choudhary, Mukul Dixit, Anjana Verma, Hemlata Mittal, Medha Mathur


Background: Scrub typhus is an acute febrile bacterial zoonoses, caused by Orientia tsutsugamushi and is associated with a range of complications, including sepsis, Acute respiratory distress syndrome (ARDS), pre-renal azotemia and Multiorgan dysfunction syndrome (MODS). The objective of this study was to study the demographic variables and clinical profile of the patients diagnosed with scrub typhus. admitted in a tertiary care hospital in Udaipur, Rajasthan.

Methods: It was a longitudinal, observational study, conducted in a tertiary care centre in Udaipur, Rajasthan from January 2020-June 2021. All patients, diagnosed (positive for antibody IgM) with scrub typhus in the hospital during the study period were included in the study. Information about the patients was collected using a pre-tested questionnaire and clinical examination, after taking the informed consent from the study participants.

Results: Mean age of the patients was 36.4±19 years. Majority (69.4%) of the patients were from rural area and fever was the most common (83.9%) symptom experienced. Eschar was found in only 1.6% of patients. About 87.1% of the patients had complications, with MODS, being the most common affecting about 34% of the total patients. The patients from rural areas were found to have significantly higher odds (OR=1.61) of having complications as compared to urban area patients (CI=1.09-4.3).  

Conclusions: This article draws attention to the fact that scrub typhus is quite on rise and most of the cases are associated with complications. There is a need to develop effective strategies and interventions to stop this rampant rise of the cases in India.



Clinical, Scrub typhus, India, Rajasthan

Full Text:



Walker DH, Damler JS, Marrie T. Harrison’s Principles of Internal Medicine. 18th ed. New York, NY: McGraw Hill; 2012: 1413.

Oberoi A, Varghese SR. Scrub typhus-an emerging entity: a study from a tertiary care hospital in North India. Indian J Public Health. 2014;58(4):281-3.

Mathai E, Rolain JM, Verghese GM, Abraham OC, Mathai D, Mathai M, et al. Outbreak of scrub typhus in southern India during the cooler months. Ann N Y Acad Sci. 2003;990:359-64.

Aggarwal HK, Jain D, Kaverappa V, Mittal A, Yadav S, Gupta A. Emergence of Scrub Typhus in Northern India: Experience from Tertiary Care Hospital. Klimik Dergisi. 2014;27:6-11.

Wang CC, Liu SF, Liu JW, Chung YH, Su MC, Lin MC. Acute respiratory distress syndrome in scrub typhus. Am J Trop Med Hyg. 2007;76:1148-52.

Yen TH, Chang CT, Lin JL, Jiang JR, Lee KF. Scrub typhus: a frequently overlooked cause of acute renal failure. Ren Fail. 2003;25(3):397-410.

Cracco C, Delafosse C, Baril L, Lefort Y, Morelot C, Derenne JP, et al. Multiple organ failure complicating probable scrub typhus. Clin Infect Dis. 2000;31(1):191-2.

Thap LC, Supanaranond W, Treeprasertsuk S, Kitvatanachai S, Chinprasatsak S, Phonrat B. Septic shock secondary to scrub typhus: characteristics and complications. Southeast Asian J Trop Med Public Health. 2002;33(4):780-6.

Isaac R, Varghese GM, Mathai E, Joseph I. Scrub typhus: prevalence and diagnostic issues in rural Southern India. Clin Infect Dis. 2004;39(9):1395-6.

Pathania M, Malik AP, Rathaur VK. Scrub typhus: Overview of demographic variables, clinical profile, and diagnostic issues in the sub-Himalayan region of India and its comparison to other Indian and Asian studies. J Family Med Prim Care. 2019;8(3):1189-95.

Gautam R, Parajuli K, Sherchand JB. Epidemiology, Risk Factors and Seasonal Variation of Scrub Typhus Fever in Central Nepal. Trop Med Infect Dis. 2019;4(1):27.

Oberoi A, Varghese SR. Scrub typhus-an emerging entity: a study from a tertiary care hospital in North India. Indian J Public Health. 2014;58(4):281-3.

Jain D, Nand N, Giri K, Bhutani J. Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India. Med Pharm Rep. 2019;92(1):36-42.