DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20213827

COVID-19 and thrombosis

Kavita Verma, Anjali Sharma, Shahzad Sarosh Bulsara

Abstract


The first case of novel corona virus disease (COVID-19) was reported in China and undoubtedly today this disease has rapidly crossed borders, infecting people throughout the world. There are heaps of complications related to COVID-19 namely acute respiratory failure, acute liver and kidney injury, bacterial and fungal infections, and septic shock. Vascular thrombosis is another burden that COVID-19 is pilling on to the load of its complications. Venous thromboembolism namely deep vein thrombosis and pulmonary thromboembolism; pulmonary microvasculature thrombosis and systemic arterial thromboembolic events like limb ischemia, myocardial ischemia/infarction and cerebrovascular thrombosis are being increasingly reported in COVID-19 patients.


Keywords


COVID-19, Thrombosis

Full Text:

PDF

References


Klok FA, Kruip MJ, Van der Meer NJ, Arbous MS, Gommers DA, Kant KM, Kaptein FH, van Paassen J, Stals MA, Huisman MV, Endeman H. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thrombosis research. 2020 Jul 1;191:145-7. https://doi.org/10.1016/j.thromres.2020.04.013

Middeldorp S, Coppens M, van Haaps TF, Foppen M, Vlaar AP, Müller MC, Bouman CC, Beenen LF, Kootte RS, Heijmans J, Smits LP. Incidence of venous thromboembolism in hospitalized patients with COVID‐19. Journal of Thrombosis and Haemostasis. 2020 Aug;18(8):1995-2002. https://doi.org/10.1111/jth.14888

Willyard C. Coronavirus blood-clot mystery intensifies. Nature 2020 May; 581(7808):250.

Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Cruz CS. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology. 2020 Aug 1;7(8):e575-82. https://doi.org/10.1016/S2352-3026(20)30216-7

Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up. J Am Coll Cardiol. 2020;75(23):2950–2973. https://doi.org/10.1016/j.jacc.2020.04.031