Systemic manifestations and treatment algorithm of food allergy


  • Amal Saleh Akeel Department of Emergency Medicine, King Fahad General Hospital, Jeddah, Saudi Arabia
  • Mohammed Abdulaziz Aljawi Department of Emergency Medicine, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia
  • Ibrahiem Fahad Mutaki Department of Emergency Medicine, King Fahad Hospital, Al Ahsaa, Saudi Arabia
  • Afnan Mousa Maashi College of Medicine, Jazan University, Jazan, Saudi Arabia
  • Fahad Abdullah Almohaizey College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia
  • Ammar Abdulrahman Alnasser College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia
  • Abdulaziz Turki Nazer College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia Department of Medicine, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia
  • Mohamed Jasim AlQattan Department of Emergency Medicine, King Hamad University Hospital, Muharraq, Bahrain
  • Nasser Abdulrahman Alodayani College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia
  • May Hefdhallah Almunqedhi College of Medicine, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia
  • Rahaf Abdulsalam Alshahrani College of Medicine, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia



Allergy, Pediatrics, Hypersensitivity, Management, Manifestations


Food allergy or hypersensitivity can be defined as the presence of an observable immune secondary reaction to the administration of certain proteins that are present within the ingested foods. It has been previously estimated that around 2-10% of the general population suffer from IgE-mediated food allergy. Furthermore, identification of the manifestations is a key point to achieve appropriate evaluation and management of this condition. In this literature review, we aim to discuss the systemic manifestations and treatment algorithm for patients who suffer from a food allergy, according to the current evidence from studies in the literature. Gastrointestinal and skin-related manifestations have been reported to be the most common symptom. However, respiratory tract symptoms are also common and might severely deteriorate the affected patients. The development of severe anaphylaxis is also life-threatening with multiple organ affection. The appropriate management of food hypersensitivity is mainly based on the proper intervention from exposure to the related allergens. In addition, another appropriate management is early sensitization during the first few months of infancy to manage the symptoms of affected patients. Additionally, it should also be noted that most children usually develop tolerance, and the reported allergy to certain types of foods during childhood usually fades away by the age from 8 to12 years old and also during the period of adolescence. Future studies are needed to develop adequate management modalities with favorable safety and efficacy outcomes.


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How to Cite

Akeel, A. S., Aljawi, M. A., Mutaki, I. F., Maashi, A. M., Almohaizey, F. A., Alnasser, A. A., Nazer, A. T., AlQattan, M. J., Alodayani, N. A., Almunqedhi, M. H., & Alshahrani, R. A. (2021). Systemic manifestations and treatment algorithm of food allergy. International Journal Of Community Medicine And Public Health, 8(9), 4600–4604.



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