DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20212586

Anti-SARS-CoV-2 IgG seroprevalence among non-vaccinated healthcare workers: a study from rural North India

Pratibha Mane, Jyoti Sangwan, Kirti Lohan

Abstract


Background: Coronavirus disease 2019 (COVID-19) is an infectious disease reported in China initially which spread around the world in no time affecting millions of people. It is caused by a new coronavirus (SARS-CoV-2 or 2019 n-CoV). The healthcare workers (HCW) are at increased risk of acquiring the disease as well as antibody response.

Methods: 457 health care workers (HCW) were recruited to give blood samples for anti-SARS CoV-2 IgG testing between September to October 2020.

Results: Of the 457 participants, IgG antibodies against SARS-CoV-2 were detected in 116 health care workers (25.4%). The anti-SARS-CoV-2 antibodies were detected maximally in HCWs involved in laboratory work. Around 4 % of health care workers were RT-PCR positive form whom IgG were detected in 15 individuals (71.4%) only.

Conclusions: The study concludes a higher prevalence among health care workers involved with patient’s samples and laboratory.


Keywords


COVID-19, Health care worker, SARS-CoV-2, Seroprevalence

Full Text:

PDF

References


Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, et al. Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019. Clin Infect Dis. 2020;71(16):2027-34.

Ioannidis JPA. Coronavirus disease 2019: The harms of exaggerated information and non-evidence-based measures. Eur J Clin Invest. 2020;50(4):13222.

Thienemann F, Pinto F, Grobbee DE, Boehm M, Bazargani N, Ge J, et al. World Heart Federation Briefing on Prevention: Coronavirus Disease 2019 (COVID-19) in Low-Income Countries. Glob Heart. 2020;15(1):31.

Unnithan PS. Kerala reports first confirmed coronavirus case in India, 2020. Available at: ndiatoday.in/india/story/keralareportsfirstconfirmed-novel-coronavirus-case-in-india. Accessed on 18 May 2021.

Bhatnagar T, Murhekar MV, Soneja M, Gupta N, Giri S, Wig N, et al. Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use. Indian J Med Res. 2020;151(2):184-9.

Riddell S, Goldie S, Hill A, Eagles D, Drew TW. The effect of temperature on persistence of SARS-CoV-2 on common surfaces. Virol J. 2020;17(1):145.

Moncunill G, Mayor A, Santano R, Jimenez A, Vidal M, Tortajada M, et al. SARS-CoV-2 Seroprevalence and Antibody Kinetics Among Health Care Workers in a Spanish Hospital After 3 Months of Follow-up. J Infect Dis. 2021;223(1):62-71.

Singhal T, Shah S, Naik R, Kazi A, Thakkar P. Prevalence of COVID-19 antibodies in healthcare workers at the peak of the pandemic in Mumbai, India: A preliminary study. Indian J Med Microbiol. 2020;38(3):461-3.

Shields A, Faustini SE, Perez TM, Jossi S, Aldera E, Allen JD, et al. SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study. Thorax. 2020;75(12):1089-94.

Bulchandani VB, Shivam S, Moudgalya S, Sondhi SL. Digital herd immunity and COVID-19. Phys Biol. 2021.

Health Department Haryana. Seroprevalence of anti SARS- Cov-2 IgG antibodies in Haryana, India: A population based cross sectional study, 2020. Available at: http://nhmharyana.gov.in/WriteRead Data/userfiles/file/CoronaVirus/Final%20report%20Sero%20Survey0409. Accessed on 18 May 2021.

Siddiqui S, Naushin S, Pradhan S, Misra A, Tyagi A, Looma M, et al. SARS-CoV-2 antibody seroprevalence and stability in a tertiary care hospital-setting. Medrxiv. 2020.

Bhadade R, Harde M, Souza R, Kasbe A, Deshpande C, Dave S, et al. Appraisal of Critically Ill COVID-19 Patients at a Dedicated COVID Hospital. J Assoc Physicians India. 2020;68(9):14-9.

Wellinghausen N, Plonne D, Voss M, Ivanova R, Frodl R, Deininger S. SARS-CoV-2-IgG response is different in COVID-19 outpatients and asymptomatic contact persons. J Clin Virol. 2020;130:104542.

Goenka M, Afzalpurkar S, Goenka U, Das SS, Mukherjee M, Jajodia S, et al. Seroprevalence of COVID-19 Amongst Health Care Workers in a Tertiary Care Hospital of a Metropolitan City from India. J Assoc Physicians India. 2020;68(11):14-9.

Peeling RW, Wedderburn CJ, Garcia PJ, Boeras D, Fongwen N, Nkengasong J, Sall A, et al. Serology testing in the COVID-19 pandemic response. Lancet Infect Dis. 2020;20(9):245-9.

Gousseff M, Penot P, Gallay L, Batisse D, Benech N, Bouiller K, et al. Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?. J Infect. 2020;81(5):816-846.