Published: 2021-06-25

Dyslipidaemia among diabetes and hypertensive patients in a remote rural area of South India, in comparison with ICMR-InDiab study

Vedanayagame Dorthy, Ilango Malar, F. N. U. Anisha, Ann Sara Alexander, Ariarathinam Newtonraj, Ganesan Girija


Background: The aim of the study was to find out the prevalence and determinants of dyslipidaemia among DM and HT group in a remote rural area of India and comparing with ICMR-InDiab study.  

Methods: We screened high risk individuals (hypertension and diabetes patients) for dyslipidemia covering ten villages surrounding a Rural Health Training Centre (RHTC) located in South India, in August-September 2017. Participants were line listed from the electronic data base maintained in RHTC and were screened at their door step by visiting their house.

Results: Mean values of all lipids among the high-risk population were increased significantly (p<0.01). Prevalence of hypercholesterolemia was three times more, hypertriglyceridemia was 1.3 times higher, high LDL cholesterol was 3.3 times higher, high cholesterol HDL ratio was 1.5 times higher and isolated hypercholesterolemia was 3.6 times higher among the high-risk population. On the other hand, isolated hypertriglyceridemia has 30% less likely and isolated low HDL was 40% less likely among high risk populations in comparison to ICMR-InDiab study. Female gender [low HDL- aOR 2.1(1.1-4.2)], [high LDL- aOR 2.2(1.3-3.7)] and hypothyroidism [hypercholesterolemia- aOR 10.1(1.1-89)] were directly associated and; underweight [hypercholesterolemia- adjusted Odds ratio (aOR)- 0.4(0.2-0.9)], [hypertriglyceridemia 0.4(0.1-1.0)], and anaemia [hypertriglyceridemia aOR- 0.5(0.3-0.8)] were inversely associated with dyslipidemia.

Conclusions: Dyslipedaemia was higher among the DM and HT participants in a remote rural area of South India.


Cholesterol, Triglycerides, LDL, HDL, Dyslipidaemia, Lipid profile

Full Text:



WHO. Noncommunicable diseases country profiles, 2018. Available at: 10665/2. Accessed on 22 April 2021.

Ministry of Health and Family Welfare GOI. National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS), 2017. Available at: Accessed on 22 April 2021.

Mendis S, Puska P, Norrving B, WHO. Global atlas on cardiovascular disease prevention and control, 2011. Available at: iris/handle/10665. Accessed on 22 April 2021.

Bilen O, Kamal A, Virani SS. Lipoprotein abnormalities in South Asians and its association with cardiovascular disease: Current state and future directions. World J Cardiol. 2016;8(3):247-257.

Tripathy JP, Thakur JS, Jeet G, Chawla S, Jain S, Pal A, Prasad R. Burden and risk factors of dyslipidemia-results from a STEPS survey in Punjab India. Diabetes Metab Syndr. 2017;11(1):21-7.

Pranav CR, Kumar AS, Anuj K, Vishnupriya S, Reddy B. Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India. PLoS One. 2016;11(6):153720.

The United Nations Development Programme. sustainable Development goals, 2015. Available at: Accessed on 22 April 2021.

WHO. World health statistics 2016: monitoring health for the SDGs, sustainable development goals, 2016. Available at: handle/1066598. Accessed on 22 April 2021.

Ministry of Health and Family Welfare- GOI. National Health Policy 2017, 2018. Available at: Accessed on 22 April 2021.

Epidata Association. Epidata Software. 2014. Available at: htm#about. Accessed on 22 April 2021.

StataCorp LP. Stata data analysis and statistical Software. Spec Ed Release. 2007;10:733.

Joshi SR, Anjana RM, Deepa M, Pradeepa R, Bhansali A, Dhandania VK, et al. Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. PLoS One. 2014;9(5):96808.

Newtonraj A, Selvaraj K, Purty AJ, Nanda SK, Arokiaraj MC, Vincent A, et al. Feasibility and outcome of community-based screening for cardiovascular disease risk factors in a remote rural area of South India: The Chunampet rural-Cardiovascular health assessment and management program. Indian J Endocrinol Metab. 2019;23(6):628-34.

WHO. The STEPS Instrument and Support Material, 2016. Available at: steps/instrumentn. Accessed on 22 April 2021.

Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-97.

International Diabetes Federation. The IDF consensus worldwide definition of Metabolic Syndrome, 2006. Available at: Accessed on 22 April 2021.

Parikh RM, Mohan V. Changing definitions of metabolic syndrome. Indian J Endocrinol Metab. 2012;16(1):7-12.

Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, Kusek JW, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-12.

Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid. 2012;22(12):1200-35.

WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity, 2011. Available at: 10665/8. Accessed on 22 April 2021.

Rastgooye HA, Solhjoo M, Tavakoli MH. Correlation Between Subclinical Hypothyroidism and Dyslipidemia. Iran J Pathol. 2017;12(2):106-11.

Hussain A, Elmahdawi AM, Elzeraidi NE, Nouh F, Algathafi K. The Effects of Dyslipidemia in Subclinical Hypothyroidism. Cureus. 2019;11(11):6173.

Saric MS, Jurasic MJ, Sovic S, Kranjcec B, Glivetic T, Demarin V. Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C). Rom J Intern Med. 2017;55(3):159-66.

Denzer C, Karges B, Nake A, Rosenbauer J, Schober E, Schwab KO, et al. Subclinical hypothyroidism and dyslipidemia in children and adolescents with type 1 diabetes mellitus. Eur J Endocrinol. 2013;168(4):601-8.

Asranna A, Taneja RS, Kulshreshta B. Dyslipidemia in subclinical hypothyroidism and the effect of thyroxine on lipid profile. Indian J Endocrinol Metab. 2012;16(2):347-9.

Pearce EN. Hypothyroidism and dyslipidemia: modern concepts and approaches. Curr Cardiol Rep. 2004;6(6):451-6.

Udovcic M, Pena RH, Patham B, Tabatabai L, Kansara A. Hypothyroidism and the Heart. Methodist Debakey Cardiovasc J. 2017;13(2):55-9.

Indian Council of Medical Research. National Ethical Guidelines for Biomedial and Health Research Involving Human Participants, 2017. Available at: Accessed on 22 April 2021.