Published: 2021-04-27

Predictors of acceptance of COVID-19 vaccine among patients at a tertiary hospital in South-South Nigeria

Dennis O. Allagoa, Peter Chibuzor Oriji, Ebiye S. Tekenah, Lukman Obagah, Chidiebere Njoku, Adeniyi Stephen Afolabi, Gordon Atemie


Background: The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), which was said to have emerged from a livestock market in Wuhan, China in December 2019. The objective of this study was to determine the predictors and willingness of patients to accept the COVID-19 vaccine.

Methods: This survey was carried out at the federal medical centre, Yenagoa between 4t January and 15 February 2021. It was a descriptive cross-sectional study. The study population consisted of 1,000 consecutive patients that presented to the various out-patients departments of the hospital. Written informed consent was obtained. Data collected with a predesigned questionnaire were analysed using statistical software (SPSS for windows® version 23, SPSS Inc, Chicago, USA).

Results: Out of 1,000 participants, only 246 (24.6%) were willing to receive the COVID-19 vaccine. About 2 in every 5 participants were unwilling to take the vaccine due to trust issues. Lack of trust in the manufacturers and government were the reasons given by 43.4% and 41.8% of participants, respectively. All sociodemographic factors were significant predictors of willingness to receive COVID-19 vaccine. The male participants (OR=2.34; p=001) were 2 times more willing than women to receive COVID-19 vaccine.

Conclusions: The willingness to accept COVID-19 vaccine is low here. The highest predictor of willingness to accept the vaccine was the male gender and this is quite significant in our environment where decision-making in the family lies mostly on the man.


COVID-19, COVID-19 vaccine, Willingness, Predictor, Wuhan

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Allagoa DO, Oriji PC, Obagah L, Tekenah ES, Dambo N, Atemie G. Knowledge, Attitudes and Practices towards Covid-19 among Pregnant Women in a Tertiary Hospital in South-South, Nigeria. Int J Res Rep Gynaecol. 2020;3(3):35-41.

Shigemura J, Ursano RJ, Morganstein JC, Benedek DM. Public responses to the novel 2019 coronavirus (2019-nCoV) in Japan: Mental health consequences and target populations. Psych Clin Neurosci. 2020;74(4):277-83.

Nigeria overview. Fact sheet: Corona tracker, 2020. Available at: Accessed 11 February 2021.

Amzat J, Aminu K, Kolo VI, Akinyele AA, Ogundairo JA, Danjibo MC. Coronavirus outbreak in Nigeria: Burden and socio-medical response during the first 100 days. Int J Infect Dis. 2020;98:218-24.

World Top News NG. Fact sheet: Israel invents inhaler that cure COVID-19 in just 5 days, 2020. Available at: Accessed 8 February 2021.

SSRN. Fact sheet: Hesitancy towards a COVID-19 vaccine and prospects for herd immunity, 2020. Available at: Accessed 11 February 2021.

Aljazeera. Fact sheet: Which countries have reported new variants of Covid-19, 2020. Available at: Accessed 11February 2021.

Mirror. Fact sheet: New Nigerian Covid variant found in UK could be resistant to vaccines. Available at: Accessed 21 February 2021.

GAVI – the vaccine alliance. Fact sheet: Oxford scientists: how we developed our Covid-19 vaccine record time. Available at: Accessed 10 February 2021.

WHO. Fact sheet: WHO backs use of Oxford/AstraZeneca Covid vaccine for adults of all ages. Available at: Accessed 11 February 2021.

The Guardian. Fact sheet: NAFDAC approves AstraZeneca Covid-19 vaccine. Available at: Accessed 21 February 2021.

Sky News. Fact sheet: COVID-19: New study reveals how effective Pfizer's vaccine is after the first dose. Available at: Accessed 21 February 2021.

The conversation. Fact sheet: How to make COVID vaccines more effective: give people vitamin and mineral supplements. Available at: Accessed 21 February 2021.

Piltch-Loeb R, DiClemente R. The vaccine uptake continuum: applying social science theory to shift vaccine hesitancy. Vaccines (Basel). 2020;8(1):76.

Araoye MO. Research Methodology with statistics for health and social sciences. Sci Res. 2003:115-29.

Remy V, Largeron N, Quilici S, Carroll S. The economic value of vaccination: why prevention is wealth. J Mark Access Health Policy. 2014;17(7):450.

Le TT, Andreadakis Z, Kumar A, Román RG, Tollefsen S, Saville M, et al. The COVID-19 vaccine development landscape. Nat Rev Drug Discov. 2020;19(5):305-6.

Kwok KO, Lai F, Wei WI, Wong SY, Tang JW. Herd immunity–estimating the level required to halt the COVID-19 epidemics in affected countries. J Infect. 2020;80(6):32-3.

MacDonald NE. Vaccine hesitancy: definition, scope and determinants. Vaccine. 2015;33(34):4161-4.

MedRxiv. Fact sheet: Predictors of COVID-19 vaccine acceptance across time and countries, 2020. Available at: Accessed 27 February 2021.

Ruiz JB, Bell RA. Predictors of intention to vaccinate against COVID-19: results of a nationwide survey. Vaccine. 2021;39(7):1080-6.

Malik AA, McFadden SM, Elharake J, Omer SB. Determinants of COVID-19 vaccine acceptance in the US. E Clinic Med. 2020;26:100495.

MedRxiv. Fact sheet: When it is available, will we take it? Public perception of hypothetical COVID-19 vaccine in Nigeria, 2020. Available at: Accessed 24 February 2021.

Olomefa CO, Soyemi RV, Udomah BF, Owolabi AO, Ajumoke EG, Igbokwe MC, et al. Prediction of uptake of a potential Covid-19 vaccine among Nigerian adults. J Vaccines. 2021;12:442-5.

Wang J, Jing R, Lai X, Zhang H, Lyu Y, Knoll MD, et al. Acceptance of COVID-19 vaccination during the COVID-19 pandemic in China. Vaccines. 2020;8(3):482.

MedRxiv. Fact sheet: Determinants of intent to uptake Coronavirus vaccination among respondents in Saudi Arabia: a web-based national survey, 2020. Available at: Accessed 27 February 2021.

Marti M, de-Cola M, MacDonald NE, Dumolard L, Duclos P. Assessments of global drivers of vaccine hesitancy in 2014-looking beyond safety concerns. PloS one. 2017;12(3):0172310.

Lazarus JV, Ratzan SC, Palayew A, Gostin LO, Larson HJ, Rabin K, et al. A global survey of potential acceptance of a COVID-19 vaccine. Nature Med. 2020;20:1-4.