Pharmacoepidemiological assessment of endocrine disorders in a tertiary care teaching hospital
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20211761Keywords:
Diabetes mellitus, Drug use, Hyperthyroidism, Hypothyroidism, PrevalenceAbstract
Background: The endocrine disorders such as diabetes mellitus, hypothyroidism and hyperthyroidism along with world’s ageing population has increased the burden of health care systems. The present study aimed to assess the prescribing pattern of drugs in endocrine disease like diabetes and thyroid disorder and to evaluate the drug use in given healthcare against programmed criteria and standards.
Methods: A prospective observational study was conducted in 220 patients over six months in a tertiary care teaching hospital. Patients who are diagnosed with endocrine disorder in various (general medicine, surgery and Orthopedics) inpatient departments of study hospital.
Results: A prospective observational study was carried out by reviewing prescriptions of 220 patients with lifestyle disorders such as, DM (120), hyperthyroidism (50) and hypothyroidism (50). In diabetes, most of the patients were prescribed with biguanides 75 (47.17%) followed by sulfonylureas 56 (35.22%), alpha-glycosidase inhibitors 20 (12.58%), dipeptidyl peptidase 4 inhibitors 5 (3.14%), meglitinides 2 (1.26%) and thiazolidinediones 1 (0.63%). Most of the prescription containing insulin Actrapid and insulin Mixtard 14 (82.35%) followed by insulin Actrapid and insulin NPH 2 (11.76%), insulin Mixtard and insulin Glargine 1 (5.89%). In hypothyroidism most of the patients were prescribed with propylthiouracil 28 (56%) followed by methimazole 26 (44%). Levothyroxine is the best choice of drug for hypothyroid disorder.
Conclusions: Our study found that treatment and management of endocrine disorders were not rational. There is a need of clinical pharmacist involvement for a better patient care in these disorders.
References
Storm BL. Pharmacoepidemiology, 3rd Edition. London: John Wiley and sons Ltd. 2000.
Strom BL. What is pharmacoepidemiology? In: Storm BL, Kimmel SE. (eds.) A Textbook of pharamacoepidemiology 4th Edition, USA: John Willey and sons. 2006;3.
Einarson T. Pharmacoepidemiology. In: A Textbook of clinical pharmacy practice. Parathasarathi G, Hansen KN, Nahata MC. 5th Edition: Universities Press. 2009;416-22.
Ramachandran S, Swethanjali D, Bindu MH, Devaki K, Sripada R, Srinivas ED et al. Drug Utilization Evaluation on Antidiabetic, Thyroid and Antithyroid Drugs. Biomed Pharmacol J. 2020;13(4):1839-44.
Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Endocrinologic disorders. In: Pharmacotherapy A pathophysiologic approach. 7th Edition. New York: Mc Grow Hill Medical. 2008;1236.
Sherman SI, Talbert RL. Thyroid disorders. In: Pharmacotherapy A pathophysiologic approach. Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. 7th Edition. New York: Mc Grow Hill Medical. 2008;1243-64.
Triplitt CL, Reasner CA, Isley WL, Dipiro JT, Talbert RL, Yee GC et al. Diabetes Mellitus. In: Pharmacotherapy A pathophysiologic approach. 7th Edition. New York: Mc Grow Hill Medical. 2008;1205-42.
Pramanik S, Gosh S, Mukhopadhyay P, Bhattacharjee R, Mukherjee B, Mondal SA et al. Thyroid status in patients with type 2 diabetes attending a tertiary care hospital in Eastern India. Indian J Endocrinol Metab. 2018;22(1):112-5.
Baby N, Tom C, Joseph AA, Abraham A, Nanjwade BK. Prescribing Pattern of Antidiabetic Drugs for Type 2 Diabetic in Tertiary Care Teaching Hospital. World J Pharm Pharm Sci. 2017;6(3):1302-15.
Sharma JK, Parmar SP. Prescribing pattern of anti-diabetic drugs in patients suffering from type 2 diabetes mellitus with co-existing hypertension in a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2018;7:761-6.
Mahmood M, Reddy RC, Lahari JR, Fatima S, Shinde P, Reddy SA. Prescription pattern analysis of antidiabetic drugs in diabetes mellitus and associated comorbidities. Clin investigation. 2017;8(1):5-12.
Patel B, Oza B, Patel KP, Malhotra SD, Patel VJ. Pattern of antidiabetic drugs use in type-2 diabetic patients in a medicine outpatient clinic of a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2013;2:485-91.
Chowdhury A, Sen N, Banik S. Prescribing pattern of antidiabetic drugs in type 2 diabetic patients of Noakhali city in Bangladesh. Marmara Pharm J. 2017;21(4):1010-14.
Venkateswaramurthy N, Md. Shajeem S, Sambathkumar R. Prescribing pattern of antidiabetic drugs in type-2 diabetic patients. Int J Pharm Sci Res. 2016;7(11):4550-55.
Agarwal AA, Jadhav PR, Deshmukh YA. Prescribing pattern and efficacy of anti-diabetic drugs in maintaining optimal glycemic levels in diabetic patients. J Basic Clin Pharma. 2014;5:79-83.