Association of adult hippocampal neurogenesis with alzheimer’s disease

Authors

  • Atryee Gope Department of Applied Biosciences and Biotechnology, Imperial College London

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20205006

Keywords:

Dementia, Alzheimer’s disease, Neurogenesis, Adult hippocampal neurogenesis, Neural stem cells, Stem cell-based therapy

Abstract

Neurogenesis in the adult brain has been reported to occur within three distinct regions, of which Hippocampus is the most studied one because of its importance in cognition and memory. Alzheimer’s disease attributes to almost 62% of all dementia cases. A recent study has established a link between adult hippocampal neurogenesis and alzheimer’s disease wherein a sharp decline in AHN is observed in patients suffering from alzheimer’s. This review summarizes alzheimer’s disease, the decline in AHN in alzheimer’s patients and probes into the efficacy of the newly generated hippocampal neurons in the context of memory and cognition. It also discusses the potential of targeting reduced AHN in alzheimer’s patients using neural stem cell-based therapy.

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Published

2020-11-25

How to Cite

Gope, A. (2020). Association of adult hippocampal neurogenesis with alzheimer’s disease. International Journal Of Community Medicine And Public Health, 7(12), 5208–5212. https://doi.org/10.18203/2394-6040.ijcmph20205006

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Section

Review Articles