DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20205176

Association of peak expiratory flow rate with obese and overweight individuals

Mohd Abass Dar, Nidhi Jain, Showkat Ahmad Bhat, Neeru Garg

Abstract


Background: The increasing number of overweight and obese individuals is a serious health problem worldwide. Growing evidence had clearly and consistently evidenced that obesity is an essential and direct predictor of respiratory function. Aim and objectives were to observe body mass index (BMI) based variations in respiratory parameter in overweight and obese individuals.  

Methods: The study was carried out on 320 (18-28 years) subjects in district Dehradun of Uttarakhand, India. Different anthropometric parameters and respiratory parameter was measured by proper procedures.  

Results: The anthropometric parameters weight and height were found statistically significant (p<0.05) among all subjects. BMI based and gender-based comparison of respiratory parameter were found statistically significant (p<0.05). The correlation of BMI with peak expiratory flow rate (PEFR) was found statistically very highly significant. The correlation coefficient (r) between BMI with PEFR was found= -0.6, denotes partial negative correlation.

Conclusions: Our study concluded that with increased BMI the PEFR decreases, which signifies that there is broncho construction due to various mechanisms like direct action of adipose tissue on the air ways via a decrease in luminal diameter of the air way and an increase in the probability of airway collapse.


Keywords


Respiratory, Obese, Anthropometric parameters, Body mass index

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References


Afshin A, Forouzanfar MH, Reitsma MB. Health effects of overweight and obesity in 195 countries over 25 years: the GBD 2015 Obesity Collaborators. N Engl J Med. 2017;377.

De Oliveira ML, Santos LM, da Silva EN. Direct healthcare cost of obesity in Brazil: an application of cost of illness method from the perspective of the health system in 2011. PLoS One. 2015;10:0121160.

WHO 2002. International Agency for Research on Cancer, IARC Handbooks of Cancer prevention-weight control and physical Activity, IARC Press, Lyon 2002.

Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Di Rosa G, et al. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2014;16:378–400.

Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González A, Esquivel-Chirino C, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011;12:3117-32.

Fonseca-Alaniz MH, Takada J, Alonso-Vale MI, Lima FB. Adipose tissue as an endocrine: organ: from theory to practice. J Pediatr. 2007;83:192-203.

Naugler WE, Karin M. The wolf in sheep’s clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 2008;14:109-19.

Pedersen JM, Budtz-Jørgensen E, Mortensen EL, Bruunsgaard H, Osler M, Sørensen TI, et al. Late midlife C-reactive protein and interleukin-6 in middle aged danish men in relation to body size history within and across generations. Obesity. 2016;24:461–8.

Stenlöf K, Wernstedt I, Fjällman T, Wallenius V, Wallenius K, Jansson JO. Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects. J Clin Endocrinol Metab. 2003;88:4379-83.

Drougard A, Fournel A, Valet P, Knauf C. Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake. Front Neurosci. 2015;9:56.

Neeru G, Punam V, Nidhi J. Comparative Study of Pulmonary and Anthropometric Parameters in Females of Garwal. Int J Contemp Medic Res. 2016;3(7):2554-7379.

Dharamshi HA, Faraz A, Ashraf E, Abbas A, Ali M. Variations of peak expiratory flow rate with body mass index in medical students of Karachi, Pakistan. Int Arch Medic. 2015;8(121):1-5.

Wright BM, McKERROW CB (November 1959). Maximum forced expiratory flow rate as a measure of ventilatory capacity: with a description of a new portable instrument for measuring it. Br Med J. 2 (5159):1041-6.

Quetelet LAJ (1871). Anthropometrie ou Mesure des Differences Faculties de I ’Homme. Brussels: Musquardt.

Tandon K. Obesity, its distribution pattern and health implications among Khatri population. Unpublished Ph. D. theses, Department of Anthropology, University of Delhi, Delhi. 2006.

Neeru G, Punam V, Nidhi J. Comparative Study of Pulmonary and Anthropometric Parameters in Females of Garwal. Int J Contemp Medic Res. 2016;3(7):2554-7379.

Thiago TM, Rogerio R, Claudia HC, Agnaldo JL. Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function. Multidiscipli Res Medic. 2016;11:28