Healing the chronic wounds in diabetes using old drugs

Khaled M. Hassan, Abdullah A. Hamdi, Suhail A. Alhamad, Reem Q. Alanzi, Yousef A. Aleid, Abdullah S. Aldarwish, Abdullah H. Almuntashiri, Khalid Y. Almudawi, Abdullah A. Alkhalifah, Alaa F. Banjabi, Sarah H. Al-matar, Turki S. Al-ayash, Duaa J. Basrawi, Mashael I. Aleidan, Muataz I. Alnami, Mohammed A. Aljumaiah


People with uncontrolled diabetes may develop poor circulation. As circulation slows down, blood moves more slowly, which makes it more difficult for the body to deliver nutrients to wounds. As a result, the injuries heal slowly, or may not heal at all. Due to the effects of diabetes on the nerves and blood vessels, diabetic patients might also experience other complications. These include heart disease, kidney disease, and eye problems. Hence, the need for therapeutic drugs is a must. In this review we analyze some drugs that have been used in diabetes wound healing including antiglycemic agents like dipeptidylpeptidase-4 (DPP4) inhibitors and metformin, statins and phenytoin. These drugs showed satisfying results giving the diabetes patients a glimmer of hop regarding their wound healing.



Chronic wounds, Wound closure, Diabetic foot ulcer, Dipeptidylpeptidase-4 inhibitor, Metformin, Phenytoin, Statins, Drug repurposing

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