Association of transfusion transmitted infections with ABO and Rh D blood group system in healthy blood donors: a retrospective analysis

Authors

  • Satya Prakash Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
  • Dibyajyoti Sahoo Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
  • Debasish Mishra Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
  • Sumansudha Routray Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
  • Gopal Krushna Ray Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
  • Pankaj Kumar Das Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
  • Somnath Mukherjee Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20204743

Keywords:

ABO Blood group system, Blood donor, Blood transfusion, Seroprevalence, Transfusion transmitted infections

Abstract

Background: Transfusion transmitted infections (TTIs) involves several adverse consequences. Studies have shown that ABO blood groups have some association with various infectious and non-infectious diseases. Few blood groups even can act as a receptor and ligand for infectious agents. The objective of the study was to find out any significant association of TTIs with various ABO and Rh D blood group system.

Methods: This retrospective study was conducted from July 2016 to October 2018. Blood donors’ blood was tested for ABO and Rh D grouping and five mandatory TTI markers as per Drugs and Cosmetics Act. Chi-square test was performed to look for any association of TTIs with ABO and Rh D blood group.

Results: 10,510 healthy donors were screened for TTI and 199 (1.89%) were positive for various TTIs. Hepatitis B had maximum prevalence (102 cases, 0.97%) followed by Hepatitis C (44 cases, 0.41%) and HIV (37 cases, 0.35%). Maximum TTI seroreactive donors were found among ‘B’ blood group (2.21%, 77 cases) followed group ‘A’ donors (2.16%, 53 cases), ‘O’ donors (1.57%, 60 cases) and ‘AB’ donors (1.17%, 9 cases), respectively. However, the risk of association of TTI was not statistically significant with ABO and Rh D blood group.

Conclusions: Although no significant association was observed between ABO and Rh D blood groups with TTIs, Hepatitis B was found to be most common infection in blood donors. This high prevalence points towards critical need of comprehensive public health approach to achieve elimination of TTI.

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Published

2020-10-26

How to Cite

Prakash, S., Sahoo, D., Mishra, D., Routray, S., Ray, G. K., Das, P. K., & Mukherjee, S. (2020). Association of transfusion transmitted infections with ABO and Rh D blood group system in healthy blood donors: a retrospective analysis. International Journal Of Community Medicine And Public Health, 7(11), 4444–4448. https://doi.org/10.18203/2394-6040.ijcmph20204743

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Original Research Articles