Correlation of diabetes with mycotic infections: a pilot study
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20211214Keywords:
Aspergillosis, Diabetes, ZygomycosisAbstract
Background: The immuno-compromised individuals have a high Incidence of fungal infections of the nose and the paranasal sinuses. There is a variation in the fungal species that manifest in different subset of individuals. The species and the susceptible individuals were studied in the Punjab population, to suggest measures to attain a better outcome.
Methods: 50 subjects treated for paranasal fungal infection by rhinology division of the oto-rhino-laryngology services, Dayanand Medical College and hospital, Ludhiana, were analysed. The prospective study was carried out in a period of one and a half year (June 2009 to December 2010).
Results: Mycotic infections was predominantly noted in the age group 51-60 years i.e. in 14 patients (28%) followed by 41-50 years, 13 cases (26%). There were 29 (58%) of males and 21 (42%) females with a male:female ratio of 1.4:1. Amongst 50 patients with mycotic infection, 19 (38%) were diabetic. All 15 (100%) patients with zygomycosis had underlying diabetes while only 4 (21%) with aspergillosis were diabetic.
Conclusions: Zygomycosis occurs usually in diabetics, while in aspergillosis the underlying morbidity may or may not be diabetes. Timely medical treatment is essential to check diabetes and species identification to select the appropriate antifungal medication.
References
Kulkarni AM, Mudholkar VG, Acharya AS, Ramteke RV. Histopathological study of lesions of nose and paranasal sinuses. Indian J Otolaryngol Head Neck Surg. 2012;64(3):275-9.
Zafar U, Khan N, Afroz N, Hasan SA Clinicopathological study of non-.neoplastic lesions of nasal cavity and paranasal sinuses. Indian J Pathol Microbiol. 2008; 51 (1):26-9.
Rawat OS, Chatham V, Grover M, Johan T, Verma PC. Clinic-pathological profile and management of sino-nasal masses: a prospective study. Indian J Otolaryngol Head Neck Surg. 2013;65(2):S388-93.
Dhillon V, Dhingra R, Davessar JL, Chaudhary A, Monga S, Kaur M, et al. Correlation of clinical, radiological and histopathological diagnosis among patients with sinonasal masses. IJCMR. 2016;3(6):1612-5.
Sharma R, Sahni D, Uppal K, Gupta R, Singla G. A clinicopathological study of masses of nasal cavity, paranasal sinuses and nasopharynx. Int J Otolaryngol Head neck Surg. 2017;3(2):253-8.
Rosai J. Respiratory tract: nasal cavity paranasal sinuses, and nasopharynx, larynx and trachea, lung and pleura. In: Rosai J editor, Rosai and Ackerman’s Surgical Pathology. 10th edn. Edinburgh: Elsevier; 2011: 291-436.
Bitar D, Van Cauteren D, Lanternier F, Dannaoui E, Che D, Dromer F, et al. increasing Incidence of Zygomycosis (Mucormycosis), France, 1997-2006. Emerg Infect Dis. 2009;15(9):1395-401.
Bhattacharya J, Goswami BK, Banerjee A, Bhattacharya R, Chakrabarti I, Giri A. A clinicopathological study of masses arising from sinonasal tract and nasopharynx in north Bengal Population with special reference to neoplasms. Egypt J Otolaryngol. 2015;31:98-104.
Chakrabarti A, Das A, Mandal J, Shivprakash MR, George VK, Tarai B, et al. The rising trend of invasive zygomycosis in patients with uncontrolled diabetes mellitus. Med Mycol. 2006;44(4):335-42.
Singh J. Alarming rise in fungal infection cases: PGIMER study. 2014. Available form: https://www. downtoearth.org.in/news/alarming-rise-in-fungal-infection-cases-pgimer-study--43222. Accessed on 15 December 2017.
