Heat stroke: what goes on at vascular level?
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20202510Keywords:
Heat stroke, PathophysiologyAbstract
Heat stroke is the most calamitous consequence of environmental heat stress affecting every age group that can be traced back to more than 2000 years. It can be defined as a form of hyperthermia associated with a systemic inflammatory response leading to multiorgan dysfunction syndrome in which encephalopathy predominates. Based on its etiology, heat stroke can be divided into classic (resulting from exposure to high environmental temperatures) (called classic or non-exertional heat stroke) or exertional heat stroke (from strenuous exercise).
References
Bouchama A, Knochel JP. Heat Stroke. N Engl J Med. 2002;346(25):1978-88.
Bloomberg - Are you a robot? 2019. Available at: https://www.bloomberg.com/news/articles/2015-06-24/heat-wave-death-toll-rises-to-2-000-in-pakistan-s-financial-hub. Accessed on 28 June 2019.
Hall D, Buettner G, Oberley L, Xu L, Matthes R, Gisolfi C. Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia. Am J Physiol-Heart Circul Physiol. 2001;280(2):H509H521.
Lim C. Heat Sepsis Precedes Heat Toxicity in the Pathophysiology of Heat Stroke—A New Paradigm on an Ancient Disease. Antioxidants. 2018;7(11):149.
Yang M, Li Z, Zhao Y, Zhou F, Zhang Y, Gao J, et al. Outcome and risk factors associated with extent of central nervous system injury due to exertional heat stroke. Medicine. 2017;96(44):e8417.
Ingole V, Rocklöv J, Juvekar S, Schumann B. Impact of Heat and Cold on Total and Cause-Specific Mortality in Vadu HDSS--A Rural Setting in Western India. Int J Environ Res Public Health. 2015;12(12):15298-308.