Prevalence and clinical profile of metabolic syndrome amongst essential hypertensive patients at Navi Mumbai, India

Ketan L. Pakhale, Rajshree K. Pakhale, Archana R. Bhate, Shyam C. More


Background: The prevalence of metabolic syndrome (MetS), a pathophysiological and asymptomatic state of numerous complications has been documented in various recent studies worldwide. Inadequate data are available highlighting the magnitude of MetS in country like India whose major health problem has been infectious disease rather than non-communicable disease like hypertension. The aim of the present study was to determine the prevalence of MetS in essential hypertensive patients using the criteria of the National Cholesterol Education Program's adult treatment panel III.

Methods: A cross-sectional study was conducted on 80 hypertensive patients above the age of 40 years at OPD of School of Medicine, D. Y. Patil Deemed to be University, Navi Mumbai. Various anthropometric, biochemical, echocardiographic and ophthalmoscopic data were recorded from the patients using standardized laboratory protocols.

Results: Our studies revealed a prevalence rate of 17.5% of MetS in patients with essential hypertension. Triglyceride level abnormality was found to be more prevalent in our cohort whereas 17% of the total population displayed central obesity. Elevated blood sugar levels were exhibited by 85% of the population revealing the susceptibility towards diabetic condition. Echocardiographic data revealed complications such as concentric left ventricular hypertrophy, global hypokinesia and low heart’s ejection fraction ability in some subjects. Our ophthalmoscopic data is suggestive of hypertension related eye complications in half of our study population.

Conclusions: Collectively our results demonstrate an increased prevalence of MetS, therefore early detection and management of MetS in individuals with high risk can aid in preventing many complications in patients.


BMI, Hypertension, HDL, Metabolic syndrome, Obesity, Triglycerides

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Alberti KG, Eckel RH, Grundy SM. Harmonizing the metabolic syndrome. Circulation. 2009;120(16):1640-5.

Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5):231-7.

Alberti KG, Zimmet P, Shaw J. The metabolic syndrome-a new worldwide definition. Lancet. 2005;366(9491):1059-62.

Grundy SM, Cleeman JI, Daniels SR. Diagnosis and management of the metabolic syndrome. Circulation. 2005;112(17):2735-52.

Kearney PM, Whelton M, Reynolds K, Mountner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-23.

Khan SH, Khan FA, Ijaz A, Sattar A, Dilwar M, Hashim R. Hypertension and metabolic syndrome: impact of clustering of hypertension in subjects with metabolic syndrome. Pak Med Sci. 2007;23:903-8.

Reaven GM. Insulin resistance, compensatory hyperinsulinemia and coronary heart disease: syndrome X revisited. In: Jefferson LS, Cherrington AD, eds. Handbook of physiology. Section 7: The endocrine system. Vol. II: The endocrine pancreas and regulation of metabolism. New York. Oxford University Press. 2001:1169-1197.

Flakoll PJ, Jensen MD, Cherrington AD. Physiological action of insulin. In: LeRoith D, Taylor SI, Olefasky JM, eds. Diabetes mellitus: a fundamental and clinical text. 3rd ed. Philadelphia: Lippincott, Williams and Wilkins. 2004;165-181.

Wang LC, Goalstone ML, Draznin B. Molecular mechanisms of insulin resistance that impact cardiovacsular biology. Diabetes. 2004;53:2735-40.

Reaven GM. Insulin resistance and its consequences. In: LeRoith D, Taylor SI, Olefasky JM, eds. Diabetes mellitus: a fundamental and clinical text. 3rd ed. Philadelphia: Lippincott, Williams and Wilkins. 2004;899-915.

Sowers JR, Fronlich ED. Insulin and insulin resistance: impact on blood pressure and cardiovascular disease. Med Clin North Am. 2004;88:63-82.

Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2005;28(9):2289-304.

Ambade VN, Sharma YV, Somani BL. Methods for estimation of blood glucose: a comparative evaluation. Med J Armed Forces India. 1998;54(2):131-3.

Akholkar PJ, Gandhi AA, Shah CM. The metabolic syndrome among hypertensive patients: a cross-sectional study. Int J Advances Med. 2015;2(3):188-91.

Gibson RS. Principles of nutritional assessment. USA: Oxford University Press. 2005.

Sheldon WH. The varieties of human physique. 1940; Oxford, England: Harper and brothers.

Willer KA, Harreiter J, Pacini G. Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. Endocr Rev. 2016;37(3):278-316.

Lee J, Park J. Role of echocardiography in clinical hypertension. Clin Hypertens. 2015;21:9.

Carretero OA, Oparil S. Essential hypertension part I: definition and aetiology. Circulation. 2000;101(3):329-35.

Vuvor F. Correlation of body mass index and blood pressure of adults of 30-50 years of age in Ghana. J Health Res Rev. 2017;4:115-21.

Rantala AO, Kauma H, Lilja M, Savolainen MJ, Reunanen A, Kesaniemi YA. Prevalence of the metabolic syndrome in drug­treated hypertensive patients and control subjects. J Int Med. 2001;245(2):163-74.

Narkiewicz K. Obesity and hypertension- the issue is more complex than we thought. Nephrol Dialysis Transplant. 2006;21(2):264-7.

Libby P. The pathogenesis, prevention, and treatment of atherosclerosis. In Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison`s principles of Internal Medicine. 18th edition. Mc Graw Hill. 2011:1983.

Osuji CU, Omejua EG. Prevalence and characteristics of the metabolic syndrome among newly diagnosed hypertensive patients. Indian J Endocrinol Metab. 2012;16(1):104-9.

Pushpa S, Mahadeva SK, Raghunath H, Suhasa U, Hamsa M. Metabolic syndrome and its component among population of Holalu village, Karnataka. Int J Med Sci Public Health. 2016;5(5):860-5.

Mule G, Nardi E, Cottone S, Cusimano P, Volpe V, Piazza G, et al. Influence of metabolic syndrome on hypertension related target organ damage. J Intern Med. 2005;257:503-13.

Ulasi II, Ijoma CK, Onodugo OD. A community-based study of hypertension and cardio-metabolic syndrome in semi-urban and rural communities in Nigeria. BMC Health Ser Res. 2010;10:71.

Makwana D, Bagga S, Nandal M. Prevalence of metabolic syndrome in patients with essential hypertension. Indian J Clin Practice. 2014;24(9):44-9.