DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20201963

Renal cell carcinoma at the time of presentation: a 5-year radiological survey at a tertiary care cancer hospital

Muhammad Omer Altaf, Asma Riaz, Mehreen Shafqat, Hamd Zahra, Naila Iqbal, Aamer Iftikhar

Abstract


Background: Renal cell carcinoma (RCC) is associated with highest mortality rates of all the genitourinary tumors with increased incidence in the past few decades. It is heterogenous tumor with several histological types. Main diagnostic approach is radiological imaging followed by histopathology.

Methods: It is a retrospective study conducted at a tertiary care cancer hospital in Pakistan. We reviewed the record of all the RCC patients in terms of age, gender, radiological manifestation of tumor size, polarity, laterality, stage including nodal status, metastasis and histological type.

Results: Our study included 149 patients of RCC. Mean age of presentation was 57 years with a male predominance. The most common stage of presentation was stage 3 seen in 41% patients followed by stage 1 in 37% patients. nodal metastasis was observed in around 13% patients and distant metastasis in 8% patients. Also, majority of the patient had histological subtype of clear cell CA (63%) followed by papillary CA (33%).

Conclusions: Epidemiological features of renal cell CA are observed over a period of 5 years representing our population. The current trends show variation from those observed in developed countries depicting the struggle of healthcare awareness in developing countries.


Keywords


Carcinoma, Epidemiology, Metastasis, Renal cell carcinoma, Stage

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References


Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA: A Cancer J Clinic. 2016;66(1):7-30.

Kovacs G, Akhtar M, Beckwith BJ, Bugert P, Cooper CS, Delahunt B, et al. The Heidelberg classification of renal cell tumours. J Pathol. 1997;183(2):131-3.

Chow WH, Devesa SS, Warren JL, Fraumeni JF. Rising incidence of renal cell cancer in the United States. JAMA. 1999;281:1628-31.

McPhee SJ, Papadakis MA. Current Medical Diagnosis and Treatment 2009. McGraw-Hill Professional; 2008.

Federle MP, Jeffrey RB, Woodward PJ. Diagnostic Imaging: Abdomen, Published by Amirsys®. Lippincott Williams and Wilkins; 2009:ISBN:1931884714.

Venkatesan AM, Wood BJ, Gervais DA. Percutaneous ablation in the kidney. Radiol. 2011;261(2):375-91.

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225-49.

Decastro GJ, McKiernan JM. Epidemiology, clinical staging, and presentation of renal cell carcinoma. Urol Clin North Am. 2008;35:581-92.

Jain Y, Liew S, Taylor MB, Bonington SC. Is dual-phase abdominal CT necessary for the optimal detection of metastases from renal cell carcinoma?. Clin Radiol. 2011;66(11):1055-9.

Ascenti G, Gaeta M, Magno C, Mazziotti S, Blandino A, Melloni D, et al. Contrast-enhanced second-harmonic sonography in the detection of pseudocapsule in renal cell carcinoma. AJR Am J Roentgenol. 2004;182(6):1525-30.

Ng CS, Wood CG, Silverman PM, Tannir NM, Tamboli P, Sandler CM. Renal cell carcinoma: diagnosis, staging, and surveillance. AJR Am J Roentgenol. 2008;191(4):1220-32.

Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Inter J Cancer. 2010;127(12):2893-917.

Agnihotri S, Kumar J, Jain M, Kapoor R, Mandhani A. Renal cell carcinoma in India demonstrates early age of onset and a late stage of presentation. Indian J Med Res. 2014;140(5):624-9.

Luke C, Sargent N, Pittman K, Price T, Roder D. Epidemiology of cancers of the kidney in an Australian population. Asian Pac J Cancer Prev. 2011;12:2893-9.

Gillett MD, Cheville JC, Karnes RJ, Lohse CM, Kwon ED, Leibovich BC, et al. Comparison of presentation and outcome for patients 18 to 40 and 60 to 70 years old with solid renal masses. J Urol. 2005;173:1893.

Krambeck A, Iwaszko M, Leibovich B. Long-term outcome of multiple ipsilateral renal tumours found at the time of planned nephron-sparing surgery. BJU Int. 2008;101:1375-9.

Jun C, Zhishun X, Xianzhou J, Qiang F, Jin W. Association between age and clinical characteristics of renal cell carcinoma in adult patients. Int J Urol. 2006;13:515-9.

Hashmi AA, Ali R, Hussain ZF, Faridi N. Clinicopathologic patterns of adult renal tumors in Pakistan. Asian Pac J Cancer Prev. 2014;15:2303-7.

Agnihotri S, Kumar J, Jain M, Kapoor R, Mandhani A. Renal cell carcinoma in India demonstrates early age of onset and a late stage of presentation. Indian J Med Res. 2014;140:624-9.

Latif F, Mubarak M, Kazi JI. Histopathological characteristics of adult renal tumours: A preliminary report. J Pak Med Assoc. 2011;61:224-8.

Zini L, Destrieux-Garnier L, Leroy X, Villers A, Haulon S, Lemaitre L, et al. Renal vein ostium wall invasion of renal cell carcinoma with an inferior vena cava tumor thrombus: prediction by renal and vena caval vein diameters and prognostic significance. J Urol. 2008;179:450-4.

Négrier S, Escudier B, Gomez F, Douillard JY, Ravaud A, Chevreau C, et al. Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d’Immunotherapie. Ann Oncol. 2002;13:1460-8.

Umer M, Mohib Y, Atif M, Nazim M. Skeletal metastasis in renal cell carcinoma: a review. Ann Med Surg. 2018;27:9-16.

Hock LM, Lynch J, Balaji KC. Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data. J Urol. 2002;167:57-60.

Kawaljit S, Janak SR, Ashok G, Vishwajeet S. Decadal experience of renal cell carcinoma from a tertiary care teaching institute in North India. Indian J Surg Oncol. 2018;9(4):558-64.

Conti SL, Thomas IC, Hagedorn JC, Chung BI, Chertow GM, Wagner TH, et al. tilization of cytoreductive nephrectomy and patient survival in the targeted therapy era. Int J Cancer. 2014;134(9):2245-52.

Pal SK, Figlin RA. Targeted therapies for renal cell carcinoma: understanding their impact on survival. Target Oncol. 2010;5:131-8.

Janzen NK, Kim HL, Figlin RA, Belldegrun AS. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am. 2003;30(4):843-52.

Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471-4.

Feltrin LT, Ferreira JR, Mamere AE, Darahem R, de Souza Coelho AO, Lucchesi FR, et al. Signs of hypervascularization at magnetic resonance imaging in bone metastases from renal cell carcinoma. Radiol Bras. 2009;42(155):e7.

Tokuda N, Naito S, Matsuzaki O, Nagashima Y, Ozono S, Igarashi T. Japanese Society of Renal Cancer. J Urol. 2006;176(1):40-3.