DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20202470

Evaluation of liver function test in malaria positive cases in tertiary care hospital of Bareilly

Ajay Kumar Agarwal, Ghanshyam Dass Katiyar, Swati Khan, Bharat Chand Chaudhary, Arun Singh, Mahendra Sharma

Abstract


Background: Malaria is a life-threatening disease. The aim of this study was to evaluate liver function test in malaria positive cases.

Methods: A cross sectional study was done to find out changes in liver function test in malaria positive cases. Study was done in Central Pathology Lab, RMCH, Bareilly, Uttar Pradesh. Blood samples were collected in EDTA and plain vacutainer tube. Blood smear was examined for malaria parasite within RBCs. Malaria rapid test was done for detection of Plasmodium species and liver function test was done for effect of malaria.

Results: In this study it was found that maximum malaria positive cases (25.50%) in 21-30 years age group. and in males (22.56%) in 11-20 years age group and in females (34.75%) in 21-30 years age group. Maximum cases of P. vivax (27.66%) in 21-30 years age group, P. falciparum (33.33%) in 21-30 and 41-50 years age group and mixed malarial infection (21.92%) in 31-40 years age group was found maximum P. vivax cases (51.06%) and mixed malarial infection (65.75%) in male and maximum P. falciparum (66.67%) in female was found. Maximum above normal limit serum bilirubin (63.75%), direct serum bilirubin (67.93%), SGPT (38.45%), SGOT (70.52%) and ALP (48.01%) was found in malaria positive cases. Maximum deranged serum bilirubin (83.33%), direct bilirubin (100.00%), SGOT (100.00%), ALP (83.33%) was found in P. falciparum and maximum deranged SGPT (50.68%) was found in mixed infection.

Conclusions: Malaria remains a major health problem in developing countries it affects the liver function test which helps in management of malaria patient. 


Keywords


Plasmodium vivax, P. falciparum, SGPT, SGOT, ALP

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References


Mueller I, Zimmerman PA, Reeder JC. Plasmodium malariae and plasmodium ovale the “bashful” malaria parasites. Trends Parasitol. 2007;23:278-83.

Mendis K, Sina BJ, Marchesini P, Carter R. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg. 2001;64:97-106.

World Health Organization. Severe falciparum malaria. Trans R Soc Trop Med Hyg. 2000;94:1-90.

World Health Organization. World Malaria Report 2010. Available at http:/ /www. whqlibdoc. who.int/publications/2010/9789241564106. Accessed on 12 January 2020.

Yuda M, Ishino T. Liver invasion by malarial parasites. Cellular Microbiol. 2004;6(12):1119‐25.

Clark IA, Cowden WB. The pathophysiology of falciparum malaria. Pharmacolo Therap. 2003;99(2):221-60.

Burtis C, Ashwood E, Border B. Liver functions in Tietz Fundamentals of Clinical Chemistry, Saunders Company, Philadelphia, PA, USA, 5th edition. 2001:748-770.

Onyesom I. Activities of some liver enzymes in serum of P. falciparum malaria infected humans receiving artimisinin and non-artimisinin based combination therapy. Annals Biol Res. 2012;3(7):3097-100.

Harinasuta T, Bunnag D. The clinical features of malaria in malaria: principles and practice of malariology. Wernsdorfer WH, McGregor IA, eds, Churchil Livingstone, Edinburgh, UK. 1988;709-732.

Dacie SJ, Lewis SM. Reference ranges and normal values, Practical haematology. 10th edition, U.K., Churchill Livingstone. 2006:14-17.

Malloy HT, Evelyn KA. The determination of bilirubin with the photoelectric colorimeter. J Biol Chem. 1937;119:481-90.

Wahlefeld AW, Herz G, Bernt E. Modification of Malloy Evelyn method for a simple reliable determination of total bilirubin in serum. Scandinavian J Clin Lab Investig. 1972;29(126):11-2.

Bergmeyer HU, Horder M, Rej R. Approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2 IFCC method for aspartate aminotransferase. J Clin Chem Biochem. 1986;24:497-510.

ECCLS. Determination of catalytic activity concentration in serum of L-aspartate aminotransferase. Klinische Mitteilungen. 1989;20:198-204.

Tietz NW, Rinker AD, Shaw M. IFCC methods for the measurement of catalytic concentration of enzymes. 5. IFCC methods for alkaline phosphatise. J Clin Chem Clin Biochem. 1983;21(11):731-48.

Harrison’s Principle of Internal Medicine. 17th edition. McGraw Hill Companies Inc USA. 2008.

Ukaegbu CO, Nnachi AU, Mawak JD, Igwe CC. Incidence of concurrent malaria and thypoid fever infections in febrile patients in Jos, plateau state Nigeria. Int J Scient Technol Res. 2014;3:157-61.

Archibong OD, Ibor UA, Oyama IO, Eyo DEE, Efeffiom E, Ekup EU, et al. Prevalence of malaria fever co-infection among febrile patients attending college of health technology medical centre in Calabar, cross river state, Nigeria. Int J Curr Microbiol App Sci. 2016;5(4):825-35.

Gupta NK, Bansal SB, Jain UC, Sahare K. Study of thrombocytopenia in patients of malaria. Trop Parasitol. 2013;3(1):58-61.

Jairajpuri Z, Rana S, Jaseem S, Jetley S. Thrombocytopenia and malaria: a coincidental co-existence or a significant association? an analysis; Annals Pathol Laboratory Med. 2015;2;48-53.

Khuraiya P, Sharma SS, Thakur AS, Pandey VP, Verma S. The study of clinical, biochemical and hematological profile in malaria patients. Int J Advances Med. 2016;3:209-17.

Gill MK, Makkar M, Bhat S, Kaur T, Jain K, Dhir G. Thrombocytopenia in malaria and its correlation with different types of malaria. Annals Tropical Med Public Health. 2013;6:197-200.

Ahmad S, Adil F, Shahzad T, Yahiya Y. Severe malaria in children: Factors predictive of outcome and response to Quinine. J Pak Med Assoc. 2011;61:54-8.

Okwubuo RO, David DL, Houmsou RS, Egeonu SU., Akwa Y. Assessment of some liver enzymes and serum bilirubin levels among malaria infected patients in Galingo, Taraba State. Int J Scientific Res. 2018;8(11):729-38.

Odikamnoro OO, Ikeh IM, Okoh FN, Ebiriekwe SE, Nnadozie IA, Nkwuda JO, et al. Incidence of malaria/ thypoid co-infection among adult population in unwana community, Afikpon North Local Government Area, Ebonyi State, Southeastern Nigeria. Afr J Infect Dis. 2018;12(1):33-8.

Aundhakar S, Prajapati P, Prajapati S, Aundhakar A, Kothia D, John D, et al. Study of clinical and hematological profile of plasmodium vivax malaria in a tertiary care hospital in western Maharashtra. Int J Scientific Study. 2017;5(3):257-60.

Kalavathi GP, Kumar SD. Clinical, haematological and biochemical profile of malaria cases. Int J Med Res. 2016;1(4):50-5.

Faseela TS, Roche G, Anita KB, Malli CS, Rai Y. Diagnostic value of platelet count in malaria. J Clin Diagn Res. 2011;5:464-6.

Patel A, Jain S, Patel B, Modi B. Hematological changes in P. falciparum and P. vivax malaria. National J Med Res. 2013;3(2):130-3.

Kashinkunti M, Alevoor S. Clinical, haematological and coagulation profile in malaria. Sch J App Med Sci. 2014;2(2):584-8.

Agravat AH, Dhruva GA. Haematological changes in patients of malaria. J Cell Tissue Res. 2010;10(3):2325-9.

Kochar D, Das A, Kochar S, Saxena V, Sirohi P, Garg S. Severe plasmodium vivax malaria: A report on series cases from Bikaner in North Western India. Am J Trop Med Hyg. 2009;80(2):194-8.

Kotresh N, Suresh L. Liver function abnormalities in falciparum malaria. Int J Adv Med. 2016;(4):847-50.

Dhariyal KK, Farooq U, Singh S, Shariq M, Kaur N, Bharti AK. Malaria positive cases with reference to liver function test among patients attending in Teerthanker Mahaveer Medical College and Research Center, U.P., India. Int J Scientific Study. 2016;3(12):62-7.

Sridhar D, Goel S, Farooq U, Mashkoor S. Assessment of liver enzymes in the patients infected with plasmodium. Saudi J Med Pharm Sci. 2017;3:189-94.

Abro AH, Ustadi AM, Abro HA, Abdou AS, Younis NJ, Akaila SI. Jaundice with hepatis dysfunction in falciparum malaria. J Coll Physicians Surge Pak. 2009;19:363-6.