Safety of intradermal rabies vaccine as pre-exposure prophylaxis among veterinary students
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20170261Keywords:
Intradermal rabies vaccination, Pre-exposure prophylaxis, Purified chick embryo cell rabies vaccine, Rabies, SafetyAbstract
Background: Animal bites are a major public health problem in our country. Pre-exposure vaccination using cell culture vaccines is a safe and effective method of preventing rabies and is recommended for anyone who will be at continual, frequent or increased risk of exposure to the rabies virus, as a result of their occupation, such as veterinarians, animal handlers and laboratory workers dealing with any lyssaviruses. The present study was done to assess the safety of purified chick embryo cell rabies vaccine administered as pre-exposure regimen.
Methods:The present study assessed the safety of purified chick embryo cell rabies vaccine administered as a 3 dose intradermal pre-exposure vaccination in healthy volunteered veterinary students of Government Veterinary College, Bangalore.
Results: 122 apparently healthy adults of both sex, between 18 and 30 years of age were enrolled in the study and 105 (86%) completed all three doses. A total of 342 doses of intradermal vaccine were administered, among which 38 adverse reactions were reported from 19 veterinary students. The adverse reactions were pain at the injection site 7 (2.1%), redness 13 (3.8%), itching at the site of injection 11 (3.2%), induration 6 (1.8%) and headache 1 (0.3%). All reactions subsided without any complication and none of them dropped out from the study because of any adverse drug reactions.
Conclusions:Pre-exposure vaccination is a useful tool for protecting high risk groups and purified chick embryo cell rabies vaccine has proved to be safe and well tolerated by intradermal route.
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References
World Health Organization. Rabies [online] [cited August 20, 2016]; Available from: URL http://www.who.int/mediacentre/factsheets.
Knobel DL, Cleaveland S, Coleman PG, Fèvre EM, Meltzer MI, Miranda MEG, et al. Re-evaluating the burden of rabies in Africa and Asia. Bulletin of the World Health Organization. 2005;83:360-8.
Sudarshan MK, Mahendra BJ, Madhusudana SN, Ashwath Narayana DH, Abdul Rahaman, Rao NSN, et al. An epidemiological study of animal bites in India: results of a WHO sponsored national multi-centric rabies survey. J Commun Dis. 2006;38(1):32-9.
WHO Expert Consultation on Rabies. Second report. Technical Report Series No. 982. Geneva: World Health Organization; 2013.
Trevejo RT. Rabies pre-exposure vaccination among veterinarians and at-risk staff. JAVMA. 2000;217(11):1647-50.
World Health Organization (WHO). Rabies vaccines, WHO position paper. Weekly Epidemiological Record. 2010;6;32(85):309-20.
Xianfu Wu, Smith TG, Ruppercht CE. From brain passage to cell adaptation: the road of human rabies vaccine development. Vaccine. 2011;10(11):1597-608.
Manning SE, Rupprecht CE, Fishbein D, Hanlon CA, Lumlertdacha B, Guerra M, et al. Human Rabies Prevention - United States, 2008. Recommendations of the Advisory Committee on Immunization Practices. MMWR. 2008;57(RR03);1-26,28.
World Health Organization (WHO). Rabies vaccines, WHO position paper. Weekly Epidemiological Record 2007 Dec7;49/50(82):425-35.
Madhusudana SN. Pre-exposure immunization with cell culture rabies vaccines by intradermal route: A longitudinal study of the immune responses and effect of yearly booster dose. J Basic & Applied Biomedicine. 1997;5(2):19-23.
Claudius Malerczyk, Hoshang B. Vakil, Wolfgang Bender. Rabies pre-exposure vaccination of children with purified chick embryo cell vaccine (PCECV). Human Vaccines & Immunotherapeutics. 2013; 9(7):1454-9.
Ravish HS, Srikanth J, Narayana DHA, Annadani R, Vijayashankar V, Undi M. Pre-exposure prophylaxis against rabies in children. Human Vaccines & Immunotherapeutics. 2013;9(9):1910-3.
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