The protective and antioxidant effects of gum arabic: a review of recent evidence using the new PubMed system


  • Mohammed A. Hassanien Vice presidency for educational affairs and College of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia Department of Medical Biochemistry, College of Medicine, Tanta University, Tanta, Egypt



Gum arabic, Antioxidant, Protective


Gum arabic (GA) is an exudate from acacia seyal and acacia senegal trees, which belong to the leguminosae family. There are many applications for GA, such as use as a food additive, shelf-life enhancement, microencapsulation, satiety induction, use as anti-obesity, antimicrobial, and anti-inflammatory agent, use as an anticoagulant, and applications in tumor imaging and nanotechnology. Little has been described about the mechanisms by which GA provides its protective effects, especially its role as an antioxidant, to different body tissues and organs. The aim of this study was to review the recent evidence of the antioxidant effects of GA on different body organs and tissues. The new PubMed system, which was recently released in October 2019, was used to collect and analyze data for this review. There were only seven articles in PubMed that described the antioxidant and protective effects of GA on different body organs and tissues in the period from January 2015 to November 2019; there be four articles from 2019. The results of these studies revealed the protective and antioxidant effects of GA on the liver, kidney and blood and cardiovascular system in experimentally induced injuries of these organs and tissues. Further studies are required to study the protective and antioxidant effects of GA on other body organs and tissues. The new PubMed system is a powerful and smart tool for searching and collecting data and for saving researchers time and effort; it is highly recommended to be widely used.


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Ali BH, Al-Husseni I, Beegam S, Al-Shukaili A, Nemmar A, Schierling S, et al. Effect of Gum Arabic on Oxidative Stress and Inflammation in Adenine-Induced Chronic Renal Failure in Rats. PLoS One. 2013;8(2):1-7.

Ahmed AA, Fedail JS, Musa HH, Kamboh AA, Sifaldin AZ, Musa TH. Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats. Pathophysiol Off J Int Soc Pathophysiol. 2015;22(4):189-94.

Kaddam L, Fadl-Elmula I, Eisawi OA, Abdelrazig HA, Salih MA, Lang f, et al. Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial. BMC Hematol. 2017;17:4.

Hamid M, Abdulrahim Y, Liu D, Qian G, Khan A, Huang K. The Hepatoprotective Effect of Selenium-Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride-Induced Chronic Liver Injury in Rats. J Food Sci. 2018;83(2):525-34.

Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Ali BH. Gum Arabic Ameliorates Impaired Coagulation and Cardiotoxicity Induced by Water-Pipe Smoke Exposure in Mice. Front Physiol. 2019;10:53.

Kaddam LA, Fdl-Elmula I, Eisawi OA, Abdelrazig HA, Elnimeiri MK, Saeed AM. Biochemical effects and safety of Gum arabic (Acacia Senegal) supplementation in patients with sickle cell anemia. Blood Res. 2019;54(1):31-7.

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Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Ali BH. Waterpipe Smoke Exposure Triggers Lung Injury and Functional Decline in Mice: Protective Effect of Gum Arabic. Oxid Med Cell Longev. 2019;2019:8526083.




How to Cite

Hassanien, M. A. (2019). The protective and antioxidant effects of gum arabic: a review of recent evidence using the new PubMed system. International Journal Of Community Medicine And Public Health, 7(1), 356–360.



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