Survival of patients with non-small cell lung cancer in King Abdulaziz University Hospital, Jeddah, Saudi

Marwan R. Al-Hajeili, Faris F. Alhejaili, Salwa I. A. Bakhsh, Ahmed A. Aljohaney, Omar F. Iskanderani, Atheer F. Alsulami, Maha A. Alghamdi, Wejdan A. Alghamdi, Nujoud S. Banjar


Background: The improvement in the survival rate from cancer is increased due to advancement in the early detection, combined modality therapy and right therapeutic strategies. This study was aimed to assess the survival outcomes of patients diagnosed with non-small cell lung cancer (NSCLC) at King Abdulaziz University Hospital (KAUH).

Methods: This retrospective cohort study included all patients aged 14 years and older with a diagnosis of NSCLC from 2007 to 2017 using electronic medical records at KAUH. Data analysis was performed by using Stata SE, version 15.0. Survival was defined as the time the patient lived in months from the date of pathological diagnosis to the date of last follow-up or death. All variables in a univariate and multivariate analysis were included.

Results: Adenocarcinoma was the most common type of NSCLC observed in both genders, accounting for 43.70% of all cases. Of the patients diagnosed with NSCLC the overall median survival was 12.2 months (interval=16.9). And among all variables, surgical treatment was associated with a 71% relative reduction in risk of death (hazard ratio 0.29, p<0.014), and chemotherapy a 57% relative reduction in risk of death (hazard ratio 0.43, p<0.013).

Conclusions: The median age of diagnosis of NSCLC in Kingdom of Saudi Arabia (KSA) was younger than United States of America, this could be due to many factors including smoking. The number of lung cancer cases among women was lower than men.


Lung cancer, Non-small cell lung cancer, Survival, Smoking, Adenocarcinoma, Squamous cell carcinoma, Large cell carcinoma

Full Text:



National Cancer Institute, Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Cancer of the Lung and Bronchus Available at: lungb.html. Accessed on 24 August 2019.

Jazieh AR, Al-Ghamdi M, Al-Ghanem S, Al-Garni M, Al-Kattan K, Al-Rujaib M, et al. Saudi lung cancer prevention and screening guidelines. Ann Thorac Med. 2018;13(4):198-204.

Alrawaji A, Alshahrani Z, Alzahrani W, Alomran F, Almadouj A. Cancer Incidence Report, Saudi Arabia-2014, Available at: eServices/Documents/2014.pdf. Accessed on 24 August 2019.

Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83(5):584-94.

Alamoudi OS. Lung cancer at a University Hospital in Saudi Arabia: A four-year prospective study of clinical, pathological, radiological, bronchoscopic, and biochemical parameters. Ann Thorac Med. 2010;5(1):30-6.

Alghamdi HI, Alshehri AF, Farhat GN. An overview of mortality & predictors of small-cell and non-small cell lung cancer among Saudi patients. J Epidemiol Glob Health. 2018;7 Suppl 1:S1-S6.

Moradi-Lakeh M, El Bcheraoui C, Tuffaha M, Daoud F, Al Saeedi M, Basulaiman M, et al. Tobacco consumption in the Kingdom of Saudi Arabia, 2013: findings from a national survey. BMC Public Health. 2015;15:611.

World Health Organization. Tobacco Free Initiative. 2018; Available at: research/secondhand_smoke/about/en/. Accessed on 24 August 2019.

Rahmanian SD, Diaz PT, Wewers ME. Tobacco use and cessation among women: research and treatment-related issues. J Womens Health (Larchmt). 2011;20(3):349-57.

de Perrot M, Licker M, Bouchardy C, Usel M, Robert J, Spiliopoulos A. Sex differences in presentation, management, and prognosis of patients with non-small cell lung carcinoma. J Thorac Cardiovasc Surg. 2000;119(1):21-6.

Valaitis J, Warren S, Gamble D. Increasing incidence of adenocarcinoma of the lung. Cancer. 1981;47(5):1042-6.

Xia W, Yu X, Mao Q, Xia W, Wang A, Dong G, et al. Improvement of survival for non-small cell lung cancer over time. Onco Targets Ther. 2017;10:4295-303.