A descriptive study on quality of life, depression and anxiety in chronic urticaria patients attending a tertiary care hospital in Bengaluru, South India
Keywords:Chronic urticaria, Quality of life, Psychiatric comorbidities, Depression, Anxiety
Background: Chronic urticaria (CU) is a common skin disorder characterized by the recurrent appearance of wheals typically associated with pruritis and/or angioedema for more than 6 weeks. It has a significant impact on patient’s quality of life (QoL). Hence it is of utmost importance to identify the impact of CU on the patient’s life and psychiatric comorbidities associated with it. The objectives of the study were to assess the effect of chronic urticaria on the quality of life of the patient; to assess the depression in patients with chronic urticaria; to assess the anxiety in patients with urticaria.
Methods: A total of 106 patients with chronic urticaria attending allergy clinic, KIMS Hospital during November-January 2019 (3 months) were included in the study. Informed consent was obtained. Each patient was interviewed using pretested questionnaire developed using chronic urticaria on quality of life: (CU-Q2oL), patient health questionnaire-9 (PHQ-9) and general anxiety disorder-7 (GAD-7). Data was entered in Epi-info7 and descriptive statistics were used.
Results: There were 43 (40.6%) males and 63 (59.4%) females. The mean age of the patients was 36.5±11.7 years. Quality of life was affected A lot in 9.5% of the patients and is somewhat affected in 38.7% of the CU patients. As much as 42.5% of them suffered from some grade of depression and 34.9% of them suffered from anxiety.
Conclusions: Chronic urticaria has a significant role in impairment of QOL and also leads to mental illnesses such as depression and anxiety.
Prasad PS. Urticaria. Indian J Dermatol Venereol Leprol. 2001;67(1):11–20.
World Allergy Organisation. Urticaria and Angioedema: Synopsis. 2014: 1–7. Available from: https://www.worldallergy.org/education-and-programs/education/allergic-disease-resource-center/professionals/urticaria-and-angioedema-synopsis. Accessed on 15 April 2019.
Bajaj A, Yadav S, Upadhyay A. Chronic urticaria: An overview. Indian J Dermatol. 2009;51(3):171.
Sandeep S, Vibhanshu G, Syed Suhail Amin MT. Chronic urticaria. Indian J Dermatol. 2011;56(6):622–8.
Deacock SJ. An approach to the patient with urticaria. Clin Exp Immunol. 2008;153(2):151–61.
Jáuregui I, Frutos FJO De, Ferrer M, Sastre J, Bartra J, Labrador M, et al. Assessment of Severity and Quality of Life in Chronic Urticaria. J Investig Allergol Clin Immunol. 2014;24(2):80–6.
Engin B, Uguz F, Yilmaz E, Özdemir M, Mevlitoglu I. The levels of depression, anxiety and quality of life in patients with chronic idiopathic urticaria. J Eur Acad Dermatology Venereol. 2008;22(1):36–40.
Staubach P, Dechene M, Vonend A, Metz M, Magerl M, Breuer P, et al. Quality of life in patients with chronic urticaria is differentially impaired and determined by psychiatric comorbidity. Br J Dermatol. 2006;154:294–8.
Barbosa F. Chronic idiopathic urticaria and anxiety symptoms. J Health Psychol. 2011;16(7):1308–47.
Alan S, Canan F, Karakaş AA, Geçici N. Temperament and character profiles of patients with chronic idiopathic urticaria. Postep Dermatologii i Alergol. 2015;32(3):167–72.
Uguz F, Engin B, Yilmaz E. Axis I and Axis II diagnoses in patients with chronic idiopathic urticaria. J Psychosom Res. 2008;64(2):225–9.
Baiardini I, Pasquali M, Braido F, Fumagalli F, Guerra L, Compalati E, et al. A new tool to evaluate the impact of chronic urticaria on quality of life: Chronic urticaria quality of life questionnaire (CU-Q2oL). Allergy Eur J Allergy Clin Immunol. 2005;60(8):1073–8.
Kroenke K, Spitzer RL, Williams JW. The Patient Health Questionnaire PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.
Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Lowe. A Brief Measure for Assessing Generalized Anxiety Disorder. Arch Intern Med. 2006;166(10):1092–7.
Calculation of total urticaria severity score . Indian Journal of Dermatology. Available at: http://www.e-ijd.org/viewimage.asp?img=IndianJDermatol_2015_60_1_102_147836_t1.jpg. Accessed on 09 April 2019.
Godse K. Quality of life in chronic urticaria. Indian J Dermatol. 2009;51(2):155.
Andrade G, Dias C, Oliveira S, Levy S, Baiardini I. Impact of chronic urticaria on the quality of life of patients followed up at a university hospital. An Bras Dermatol. 2016;91(6):754–9.
Pherwani A, Gadhia S, Bansode G. The impact of chronic urticaria on the quality of life in Indian patients. Indian J Dermatol. 2012;57(2):110.
Sheehan-Dare RA, Henderson MJ, Cotterill JA. Anxiety and depression in patients with chronic urticaria and generalized pruritus. Br J Dermatol. 1990;123(6):769–74.
Tat TS. Higher Levels of Depression and Anxiety in Patients with Chronic Urticaria. Med Sci Monit. 2019;25:115–20.