Socio-demographic determinants of treatment outcome in multidrug resistant tuberculosis cases registered under Programmatic management of drug resistant tuberculosis services in Amritsar, Punjab
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20192345Keywords:
MDR-TB, Socio-demographic factors, Treatment outcomes, AmritsarAbstract
Background: Multidrug resistant tuberculosis (MDR-TB) has become a major public health problem. It is associated with significant morbidity and mortality. The treatment success rate worldwide is around 50%.
Methods: This cross-sectional study was conducted on all MDR-TB patients who were registered and being treated under PMDT services in Amritsar district from 1st April 2014 to 31st March 2015. The treatment outcome with their socio-demographic determinants was ascertained. Data management and analysis was done by using Microsoft excel and SPSS.
Results: Out of 87 MDR-TB patients, 57 (65.5%) were males and 30 (34.4%) were females. The various treatment outcomes observed were- 30 (34.5%) cured, 19 (21.8%) treatment completed, 18 (20.7%) died, 13 (14.9%) defaulted, 4 (4.6%) shifted to XDR TB regime and 3 (3.4%) failure.
Conclusions: On statistical analysis, it was observed that age (p=0.000), marital status (p=0.024), educational status (p=0.011) and occupation (p=0.002) were significantly associated with the treatment outcome. Other factors like sex, type of family and socio-economic status did not affect the treatment outcome.
References
Periasamy A. Predictors of Outcome in Drug Resistant Tuberculosis Patients. J Pulm Respir Med. 2017;7:391.
Chatterjee S, Poonawala H, Jain Y. Drug resistant tuberculosis:is India ready for the challenge? BMJ Glob Health. 2018;3:e000971.
Guidelines on Programmatic Management of Drug Resistant TB in India. Central TB Division, Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, New Delhi, 2017.
Chen Y, Yuan Z, Shen X, Wu J, Wu Z, Xu B. Time to multi-drug-resistant tuberculosis treatment initiation in association with treatment outcomes in Shanghai, China. Antimicrob Agents Chemother. 2018;62:e02259-17.
Sharma SK, Kumar S, Saha PK, George N, Arora SK, Gupta D, et al. Prevalence of multidrug‑resistant tuberculosis among category II pulmonary tuberculosis patients. Indian J Med Res. 2011;133:312‑5.
Waghmare MA, Utpat K, Joshi JM. Treatment outcomes of drug-resistant pulmonary tuberculosis under programmatic management of multidrug-resistant tuberculosis, at tertiary care centre in Mumbai. Med J DY Patil Univ. 2017;10:41-5.
Pareek U, Trivedi G. Manual of socio economic scale (rural). New Delhi, Manasayan publishers; 1979.
Mohammad A. Tag El Din, Ashraf A. El Maraghly, Abdel Hay R. Adverse reactions among patients being treated for multi-drug resistant tuberculosis at Abbassia Chest Hospital. Egyptian J Chest Dis And Tuberculosis. 2015;64(4):939-52.
Manurung SMPF, Siagian P, Sinaga BYM, and Mutiara E. Factors related to successful treatment of drug-resistance tuberculosis in H. Adam Malik hospital, Medan, Indonesia. IOP Conf. Series Earth Environ Sci. 2018;125:012148.
Hire R, Kale AS, Dakhale GN, Gaikwad N. A Prospective, Observational Study of Adverse Reactions to Drug Regimen for Multi-Drug Resistant Pulmonary Tuberculosis in Central India. Meditterr J Hematol Infect Dis. 2014;6(1):e2014061.
Nair D, Velaytham B, Kannan T, Tripathy J P, Harries AD, Natrajan M, Swaminathan S. Predictors of unfavourable treatment outcome in patients with multi-drug resistant tuberculosis in India. Int Union Against Tuberculosis and Lung Disease. PHA. 2017;7(1):32-8.
Bhatt G, Vyas S, Trivedi K. An epidemiological study of multi-drug resistant tuberculosis cases registered under Revised National Tuberculosis Control Programme of Ahmedabad city. Indian J Tuberc. 2012;59:18-27.
Neeta PN, Prashanth N, Ramaprasad G, Gangadhar Goud T, Sameena A R B. A study on outcome of standardized treatment in multidrug resistance tuberculosis patients. Int J Community Med Public Health. 2016;3:257-63.
Oliveira O, Gaio R, Villar M, Duarte R. Predictors of treatment outcome in multidrug-resistant tuberculosis in Portugal. Eur Respir J. 2013;42:1747–9.
Lia D, Gea E, Shenb X, Weia X. Risk Factors of Treatment Outcomes for Multi-drug Resistant Tuberculosis in Shanghai, 2009-2012. Procedia Environ Sci. 2016;36:12 – 9.
Gafar MM, Nyazema NZ, Dambisya YM. Factors influencing treatment outcomes in tuberculosis patients in Limpopo Province, South Africa, from 2006 to 2010: A retrospective study. Curationis. 2014;37(1).
Chung- Delgado K, Guillen-Bravo S, Revilla Montag A, Bernabe-Ortiz A. Mortality among MDR-TB Cases:Comparison with Drug-Susceptible Tuberculosis and Associated Factors. PLoS ONE. 2015;10(3):e0119332.
Viana PVS, Redner P, Ramos JP. Factors associated with loss to follow-up and death in cases of drug-resistant tuberculosis (DR-TB) treated at a reference centre in Rio de Janeiro, Brazil. Cad. Saúde Pública. 2018;34(5).
Holtz TH, Lancaster J, Laserson KF, Wells CD, Thorpe L, Weyer K, et al. Risk factors associated with default from multidrug-resistant tuberculosis treatment, South Africa, 1999-2001. Int J Tuberc Lung Dis. 2006;10:649-55.