Diabetes mellitus as a risk factor for ischemic stroke: a case control study

Sumit Kumar Singh, Jayanti Semwal, Deep Shikha, Yashpal Singh, Dheeraj Bansal, Sudip Bhattacharya


Background: In developed countries, stroke is the third most common cause of mortality, following cancer and coronary heart disease. The increase risk is often seen in individuals with diabetes and is associated with poorer clinical outcomes (including higher mortality). That’s why assessment of risk factors for stroke are important.

Methods: This age and sex matched hospital based case control study assessed the risk factors of ischemic stroke in tertiary care hospital for a period of one year. Sample size was calculated for matched case control (1:1 ratio) by n-master software and came out to be 189 pairs. All patients under WHO case definition were enrolled as cases for study purpose, controls were selected from the same hospital with disease other than stroke. Analysis was conducted through calculation of odd ratio (OR) and confidence internal (CI) by using SPSS 22.0 program. Odds ratio (OR) of risk factor was calculated using bivariate analysis.

Results: Results revealed that male: female ratio among the case and control was 2.1:1, mean age of case and control were 58.86±13.03 and 58.21±12.67. Out of 189 Case, 59 (31.2%) were suffering from diabetes, while only 39 (20.6%) controls were having diabetes mellitus. P value was 0.02, which is significant.

Conclusions: In the present hospital based case control study, it was found that diabetes mellitus was a significant risk factor among the ischemic stroke patients.


Diabetes mellitus, Ischemic stroke, Case control study, Odds ratio

Full Text:



Dalal PM. Burden of stroke Indian perspective. JAPI. 2004;52:695-6.

Taylor FC, Suresh Kumar K. Stroke in India fact sheet, 2012. Hyderabad: South Asia Network for Chronic Disease; 2012.

Cheng YJ, Imperatore G, Geiss LS. Secular changes in the age-specific prevalence of diabetes among US adults: 1988-2010. Diab Care. 2013;36(9):2690-6.

International diabetes federation. IDF 5th Diabetes atlas. Belgium. Indian diabetes federation; 2011.

Chandramohan P, Mohan V. High prevalence of diabetes and metabolic syndrome among policemen. JAPI. 2008;56:837-8.

Osei K. Global epidemic of type 2 diabetes: implications for developing countries. Ethn dis. 2003;13(2):102-6.

Kissela BM, Khoury JC, Alwell K, Moomaw CJ, Woo D, Adeoye O, et al. Age at stroke: temporal trends in stroke incidence in a large, biracial population. Neurol. 2012;79(17):1781-7.

Gill TM, Allore HG, Halford TR, Guo Z. Hospitalization, restricted activity, and development of disability among older persons. JAMA. 2004;292(17):2115-24.

Sorganvi V, Kulkarni MS, Kadeli D, Atharga S. Risk factors for stroke: A case control study. Int J Cur Res Rev. 2014;06(3):4652.

The WHO STEP wise approach. Surveillance of risk factor for non-communicable diseases. Geneva: WHO, 2003.

World Health Organization (WHO) STEPS Stroke Manual. STEP wise Approach to Stroke Surveillance Manual. Available at: Accessed on 2 January 2019.

Hossain MM, Sardar MH, Hasan AH, Bari MA, Hossain SZ, Nabi G. Medical Conditions Related to Ischemic And Haemorrhagic Stroke: A Hospital Based Study. J Dhaka Med College. 2015;23(2):167-74.

Abu-Odah H, Abed Y, Abu-Hamad B. Risk Factors of Stroke in Patients Admitted in European Gaza Hospital, Gaza Strip: A case Control Study in Medical Unit Setting. J Neurol Disord Stroke. 2014;2(4):1-5.

Khodabandehlou M, Mansournia MA, Mehrpour M, Naieni KH. Risk factors associated with ischemic stroke: A case-control study. J Biostatistics Epidemiol. 2017;2(3):111-7.

Kannel WB, Mc Gee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diab Care. 1979;2(2):120-6.

Hamidon BB, Raymond AA. The impact of diabetes mellitus on in-hospital stroke mortality. J Postgrad Med. 2003;49(4):307-9.