Coverage and compliance of mass drug administration for elimination of lymphatic filariasis in Khammam district

Rajeshwar Rao Alwala, Chandrasekhar Reddy Bolla, Shankar Reddy Dudala, Y. Pravin Raju, Raston Mondal, B. P. Ravi Kumar


Background: Lymphatic filariasis (LF) is an important public health and socio-economic problem in the world and it was identified as one of the six diseases, which could be targeted for elimination /eradication. Annual mass drug administration of DEC with selective vector control could result in the effective elimination of infection by interruption of transmission. The present study aimed to find the coverage and compliance of mass drug administration (MDA) of diethyl-carbamazine (DEC) for elimination of lymphatic filariasis (LF) in Khammam district in November 2009.

Methods: Cross-sectional, population-based, house-to-house survey was conducted after the round of MDA with DEC. Multi-stage systematic sampling method was used and four clusters were selected with 30 houses in each. A pretested questionnaire was used to interview the study participants. The data collected was analyzed and coverage rate, compliance rate and effective coverage rate were calculated.

Results: The coverage rate was 65.54% with variation across different areas. The compliance with drug ingestion was 71.14%. The effective coverage (46.63%) was much below the target (85%) which has to be targeted by intensive information, education and communication (IEC). Side effects of DEC were minimum, transient and drug-specific.

Conclusions: The coverage, compliance, and effective coverage rates were found to be lower than the target, which need to be intensified by extensive IEC.



Lymphatic filariasis, Mass drug administration, Overall coverage rate, Patient compliance

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Global Alliance to Eliminate Lymphatic Filariasis, Liverpool 2018. Available at http://www.filariasis. org/about-lf/epidemiology-and-distribution-lf. Accessed 23 October 2018.

Ranganath BG. Coverage survey for assessing mass drug administration against lymphatic filariasis in Gulbarga district, Karnataka, India. J Vector Borne Dis. 2010;47:61–4.

Ottesen EA, Ismail MM, Horton J. The role of albendazole in programmes to eliminate lymphatic filariasis. Para-sitol Today. 1999;15:382-6.

Molyneux D. Lymphatic Filariasis (Elephantiasis) elimination: A public health success and development opportunity. Filarial J. 2003;2:13.

World Health Organization, Global Programme to Eliminate Lymphatic Filariasis, 2018. Available at Accessed 25 October 2018.

National Vector Borne Disease Control Programme (NVBDCP), Ministry of Health & Family Welfare, Government of India, 2018. Available at Accessed 23 October 2018.

Kumar A, Kumar P, Nagaraj K, Nayak D, Ashok L, Ashok K. A study on coverage and compliance of mass drug administration programme for elimination of filariasis in Udupi district, Karnataka, India. J Vector Borne Dis. 2009;46(3):237-40.

Babu BV, Satyanarayana K. Factors responsible for coverage and compliance in mass drug administration during the programme to eliminate lymphatic filariasis in the East Godavari district, South India. Trop Doct. 2003;33(2):79–82.

Kumar P, Prajapati P, Saxena D, Kavishwar AB, Kurian G. An Evaluation of Coverage and Compliance of Mass Drug Administration 2006 for Elimination of Lymphatic Filariasis in Endemic Areas of Gujarat. Indian J Community Med. 2008;33(1):38-42.

Agrawal VK, Sashindran VK. Lymphatic Filariasis in India : problems, challenges and new initiatives. Med J Armed Forces India. 2006;62(4):359–62.

Mukhopadhyay AK, Patnaik SK, Satya Babu P, Rao KNMB. Knowledge on lymphatic filariasis and mass drug administration (MDA) programme in filaria endemic districts of Andhra Pradesh, India. J Vector Borne Dis. 2008;45:73–5.