Clinico-epidemiological profile of patients admitted with Plasmodium vivax malaria in a tertiary care hospital, Delhi

Geeta Yadav, Geeta Pardeshi, Neelam Roy


Background: Malaria is an important public health problem in India. Severe and complicated forms of malaria are usually associated with Plasmodium falciparum species. But recently published literature suggests that Plasmodium vivax infection also presents as severe malaria. The objective was to study clinical and epidemiological profile of patients with P. vivax malaria admitted in Safdarjung hospital.

Methods: A record based retrospective study was conducted in Vardhman Mahavir Medical College & Safdarjung Hospital, a tertiary care hospital in Delhi. Data were collected from all case records with ICD 10 codes for Malaria (B50-B54) for the year 2011 obtained from Medical Records Department, Safdarjung Hospital and analyzed using SPSS 21.0.

Results: A total of 147 case records which had information about the test results for type of malaria infection were reviewed. Out of 147, 89 (60.5%) had P. vivax malaria. Of the 89 patients with P. vivax malaria, 47 (53%) were children and 63 (70.7%) were males. A peak in the number of inpatients was seen in September with median duration of hospital stay of 4 days and case fatality rate of 9%. A total of 56 (63%) patients had one or more severe manifestations of malaria as per WHO criteria. The most common severe manifestation was bleeding 27 (30%) followed by impaired consciousness 18 (20%).

Conclusions: In more than half of the malaria patients admitted at the tertiary care centre the diagnosis was P. vivax malaria. Of them 63% patients had severe malaria as per WHO criteria.


Plasmodium vivax, Severe malaria, Thrombocytopenia

Full Text:



World Health Organisation, World Malaria Report 2016. Available from media/world-malaria-report-2016/en/. Accessed on 22 June 2018.

Ministry of Health and Family Welfare, Govt. of India Annual Report 2013-14. Available from Accessed on 22 June 2018.

World Health Organization, Severe Malaria. Trop Med Int Health. 2014;19:7–131.

Verma P, Shukla US, Kalraiya A. Retrospective Study on Clinical Profile of Severe Malaria in Children Admitted in a Tertiary Care Centre of Central India. PJSR. 2014;22:22-6.

Sharma A, Khanduri U. How benign is benign tertian malaria? J Vector Borne Dis. 2009; 46:141-4.

Zubairi ABS, Nizami S, Raza A, Mehraj V, Rasheed AF, Ghanchi NK, et al. Severe Plasmodium vivax Malaria in Pakistan. Emerg Infect Dis. 2013;19:1851-4.

Saravu K, Docherl AM, Vasudev A, Shastry BA. Thrombocytopenia in vivax and falciparum malaria: an observational study of 131 patients in Karnataka, India. Ann Trop Med Parasitol. 2011;105:593–8.

Kumari M, Ghildiyal R. Clinical Profile of Plasmodium vivax Malaria in Children and Study of Severity Parameters in relation to Mortality: A Tertiary Care Centre Perspective in Mumbai, India. Malar Res Treat. 2014;2014:Article ID:765657.

Limaye CS, Londhey VA, Nabar ST. The Study of Complications of Vivax Malaria in Comparison with Falciparum Malaria in Mumbai. JAPI. 2012;60:15-8.

Kochar DK, Das A, Kochar A, Middha S, Acharya J, Tanwar GS, et al. A prospective study on adult patients of severe malaria caused by Plasmodium falciparum, Plasmodium vivax and mixed infection from Bikaner, northwest India. J Vector Borne Dis. 2014;51:200–10.

Kochar DK, Tanwar GS, Khatri PC, Kochar SK, Sengar GS, Gupta A, et al. Clinical Features of Children Hospitalized with Malaria—A Study from Bikaner, Northwest India. Hyg. 2010;83:981–9.

Goyal JP, Makwana AM. Comparison of Clinical Profile between P. vivax and P. falciparum Malaria in Children: a Tertiary Care Centre Perspective from India. Malar Res Treat. 2014;2014:132672.

Tanwar GS, Khatri PC, Chahar CK, Sengar GS, Kochar A, Tanwar G, et al. Thrombocytopenia in childhood malaria with special reference to P. vivax monoinfection: A study from Bikaner (north-western India). Platelets. 2012;23(3):211–6.

O’Brien AT, Ramírez JF, Martínez SP. A descriptive study of 16 severe Plasmodium vivax cases from three municipalities of Colombia between 2009 and 2013. Malar J. 2014;13:40-4.

Fábio ALS, Soraya BR Silva, Crepaldi NP, Nery AF, Martin TOG, Alves-Junior ER, et al. Altered platelet indices as potential markers of severe and complicated malaria caused by Plasmodium vivax: a cross-sectional descriptive study. Malar J. 2013;12:462.