A study of factors affecting weight gain among tuberculosis patients under DOTS in district Amritsar

Pooja Sadana, Harpreet Kaur, Vishal Verma


Background: Wasting is a common feature in tuberculosis and treatment is aimed at achieving weight gain in pulmonary tuberculosis patients. The aims and objectives of the study were to study the extent of body weight gain during treatment and to identify the effect of different factors on weight gain among TB patients.

Methods: The study was conducted on a total of 326 patients residing in the area of PHC Verka and registered with District Tuberculosis Centre, Amritsar. Weight change was assessed by taking the difference of weight at initial diagnosis and after completion of continuation phase therapy.

Results: A total of 228 patients participated in the study. The mean (±SD) body weights (in kg) for the patients were 44.92±12.7 at diagnosis and 48.79±12.9 at the end of treatment. The mean (±SD) weight gain was 3.86±4.55 kgs at the end of treatment. The gain in weight at the end of treatment was associated with supervision of treatment and outcome of the TB patient.

Conclusions: The findings showed that there is an association between gain in weight with supervision of treatment and outcome of the TB patient.


Tuberculosis, Weight gain, Directly observed treatment short course

Full Text:



World Health Organization. Global tuberculosis report 2015. Geneva: WHO; 2015.

WHO. Guideline: Nutritional care and support for patients with tuberculosis. Geneva: World Health Organization; 2013.

Phan MN, Guy ES, Nickson RN, Kao CC. Predictors and patterns of weight gain during treatment for tuberculosis in the United States of America. Int J Infect Dis. 2016;53:1–5.

Wassie MM, Shamil F, Worku AG. Weight Gain and Associated Factors among Adult Tuberculosis Patients on Treatment in Northwest Ethiopia: A Longitudinal Study. J Nutr Disorders Ther. 2014;4:143.

Gler MT, Guilatco R, Caoili JC, Ershova J, Cegielski P, Johnson JL. Weight Gain and Response to Treatment for Multidrug-Resistant Tuberculosis. Am J Trop Med Hyg. 2013;89(5):943-9.

Vasantha M, Gopi PG, Subramani R. Weight gain in patients with tuberculosis treated under DOTS. Indian J Tuberc. 2009;56:5–9.

Managing the Revised National Tuberculosis Control Programme in your area-A Training Course; Modules 1- 4: Central TB Division, Directorate General of Health Sciences, Ministry of Health and Family Welfare, New Delhi; 2005: 14.

TB India 2012. RNTCP Annual status report. Central TB Division. Directorate General Of Health Services, Ministry of Health and Family Welfare, New Delhi; 2012: 11.

Rohini K, Surekha B, Srikumar PS, Jyoti S, Kumar AM. Body Weight Gain in Pulmonary Tuberculosis during Chemotherapy. Int J Collab ResIntern Med Public Health. 2013;5(4):247-54.

Hoa NB, Lauritsen JM, Rieder HL. Changes in body weight and tuberculosis treatment outcome in Viet Nam. Int J Tuberc Lung Dis. 2013;17(1):61–6.

Bernabe-Ortiz A, Carcamo C P, Sanchez J F, Rios J. Weight variation over time and its association with tuberculosis treatment outcome: a longitudinal analysis. PLoS ONE. 2011;6:e18474.

Karyadi E, West CE, Schultink W, Nelwan RH, Gross R, et al. A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: effects on clinical response and nutritional status. Am J Clin Nutr. 2002;75:720-7.

WHO Geneva: Global tuberculosis Control, Surveillance, Planning, Financing. WHO/HTM/TB 2005: 49.

Khan A, Sterling TR, Reves R, Vernon A, Horsburgh CR. Lack of weight gain and relapse risk in a large tuberculosis treatment trial. Am J Respir Crit Care Med. 2006;174:344–8.