Epidemiological study of drug resistant cholera in and around Miraj, India

Authors

  • Viresh A. Nandimath Department of Community Medicine, Dr. Vaishampayan Memorial Government Medical College, Solapur, Maharashtra, India
  • Santosh A. Nandimath Department of Maxillofacial Surgery, Vokkaligara Sangha Dental College and Hospital, Bangalore, Karnataka, India
  • Chaithra S. Swamy Department of ENT, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
  • Amar R. Ukrande Department of Microbiology, Government Medical College, Miraj, Maharashtra, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20162546

Keywords:

Epidemic, El Tor, Inaba, Ogawa, Outbreak, Resistance, Vibrio cholera

Abstract

Background: Cholera is an intestinal infection caused by Vibrio cholerae. The hallmark of the disease is profuse secretory diarrhea. Cholera can be endemic, epidemic, or pandemic. Despite all the major advances in research, the condition still remains a challenge to the modern medical world. Objectives: This study was conducted to observe various epidemiological profile of cholera outbreak and to determine the antibiotic sensitivity pattern of isolates.

Methods:A descriptive study was conducted from 18th January 2010 to 31st July 2010. All confirmed cases of cholera were included in the present study during the study period. Antibiotic sensitivity testing was performed by disc diffusion method.

Results: Total 63 patients of cholera caused by Vibrio cholerae O1 were admitted in the hospital during the present study; majorities (60.32%) of cases were males and cases were more (79.36%) amongst adults (>15 years). All strains were El Tor. The outbreak started on 18th January 2010, peaked in February and lasted till 24th July 2010. Detection of V. cholera O1 biotype El Tor serotype Ogawa was 81.25% and rests (18.75%) were serotype Inaba. Clinically all cases (100%) presented with profuse watery diarrhea, 28.57% had vomiting, 20.63% had abdominal cramps while fever was present in 9.53% of cases. Majority of isolates were sensitive to amikacin and cephalexin but resistant to ampicillin and chloramphenicol.

Conclusions:Provision of safe drinking water, improving sanitation and strengthening of disease surveillance especially in coordination with local health authorities across the border is necessary to avoid recurrences of cholera. 

References

WHO Cholera Fact sheet N0 107. Cited 2016 May 1. Available at: http://www.who.int/mediacentre/ factsheets/fs107/en/.

Ghany MAE, Chander J, Mutreja A, Rashid M, Hill-Cawthorne GA, et al. The population structure of Vibrio cholerae from the Chandigarh Region of Northern India. PLoS Negl Trop Dis. 2014;8(7):e2981.

Taneja N, Biswal M, Tarai B, Sharma M. Emergence of Vibrio cholerae O1 Biotype El Tor Serotype Inaba in North India. Jpn J Infect Dis. 2005;58:238-40.

Dutta A, Q Jawed, Mahanta BN, Mahanta TG, D Payeng, Rochan Sinha. Investigation of a cholera outbreak in a tea garden of Sivasagar district of Assam. Indian Journal of Community Medicine. 2013;38(4):240-3.

Old DC. Vibrio and related genera. In: Mackey and Mackie practical medical microbiology. Collee G, Duguid P, Fraser G, Marian P.14th ed. Delhi. Churchill Livingstone Publishers; 2007:425-46.

Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disc method. Am J Clin Pathol. 1966;45:493-6.

Snider DE Jr, Stroup DF. Defining research when it comes to public health. Public Health Rep. 1997;112:29-32.

Sharma NC, Mandal PK, Dhillon R, Jain M. Changing pattern of Vibrio cholerae O1, O139 in Delhi and its periphery (2003-2005). Indian J Med Res. 2007;125(5):633-40.

Joshi A, Kale S. Cholera like expression of Escherichia E coli: an outbreak investigation from Central India. Int J Med Public Health. 2013;3(3):151-4.

Roy S, Parande MV, Mantur BG, Bhat S, Shinde R, Parande AM, et al. Multidrug-resistant Vibrio cholerae O1 in Belgaum, South India. Journal of Medical Microbiology. 2012;61:1574-9.

Chander J, Kaistha N, Gupta V, Mehta M, Singla N, Deep A, Sarkar BL. Epidemiology and antibiograms of Vibrio cholerae isolates from a tertiary care hospital in Chandigarh, North India. Indian J Med Res. 2009;129:613-7.

Mahanta BN, Mahanta TG, Sinha R, Dutta A, Payeng DJ, Jawed MQ. Cholera outbreak in tea garden of Sivasagar district of Assam. J Acad Indus Res. 2013;1(8):493-6.

Kulkarni RD, Patil SA, Kulkarni VA, Ramteerthakar M, Kumbhar V, Shah SR, Joshi PA, Jahagirdhar VL. An outbreak of cholera in the Sangli District of Maharashtra. Indian J Med Microbiol. 2007;25:76-8.

Singh J, Khanna KK, Dhariwal AC, Bhattacharjee J, Singh M, Jain DC, et al. Unusual occurrence of cholera in Delhi during January 1994: epidemiological investigations. J Diarrhoeal Dis Res. 1996;14:107-9.

Hoge CW, Bodhidatta L, Echeverria P, Deesuwan M, Kitporka P. Epidemiologic study of Vibrio cholerae 01 and 0139 in Thailand: at the advancing edge of the 8th Pandemic. Am J Epidemiol. 1996;143(3):263-8.

Sharma NC, Mandal PK, Dhillon R, Jain M. Changing profile of Vibrio cholerae O1, O139 in Delhi and its periphery (2003-2005). Indian J Med Res. 2007;125:633-40.

Nair GB, Ramamurthy T, Bhattacharya MK, Krishnan T, Ganguly S, Saha DR. Emerging trends in the etiology of enteric pathogens as evidenced from an active surveillance of hospitalized diarrhoeal patients in Kolkata. India. Gut Pathog. 2010;2(4).

Mathur M, De A, Saraswathi K, Varaiya A, Athalye S. Vibrionaceae from cases of acute diarrhoea and their antimicrobial sensitivity pattern: a five year prospective study. Indian J Med Microbiol. 2003;21(3):199-201.

Devnikar AV, Sonth SB, Baragundi MC, Solabannavar SS and Kulkarni RB. Characterization and Antibiogram of Vibrio cholerae isolates from a tertiary care hospital. Int J Biol Med Res. 2012;3(4):2352-4.

Nair GB. How much more research is required to prevent cholera? Indian J Med Res. 2007;125:612-4.

Mishra M, Mohammed F, Akulwar SL, Katkar VJ, Tankhiwale NS, Powar RM. Re-emergence of El Tor vibrio in outbreak of cholera in and around Nagpur. Indian J Med Res. 2004;120:478-80.

Taneja N, Rao P, Rao DSVR, Singh M, Sharma M. Enterotoxigenic Escherichia coli causing Cholerogenic Syndrome during an Interepidemic Period of Cholera in North India. Jpn J Infect Dis. 2006;59:245-8.

Akond MA, Alam S, Hasan SMR, Uddin SN, Shirin M. Antibiotic resistance of Vibrio cholerae from poultry sources of Dhaka, Bangladesh. Advan Biol Res. 2008;2:60-7.

Das S, Saha R, Kaur IR. Trend of antibiotic resistance of Vibrio cholerae strains from East Delhi. Indian J Med Res. 2008;127:478-82.

Jain M, Goel AK, Bhattacharya P, Ghatole M, Kamboj DV. Multidrug resistant Vibrio cholerae O1 El Tor carrying classical ctxB allele involved in a cholera outbreak in South Western India. Acta Trop. 2011;117:152-6.

Ghosh A, Ramamurthy T. Antimicrobials and cholera: are we stranded? Indian J Med Res. 2011;133:225-31.

Bhattacharya D, Sayi DS, Thamizhmani R, Bhattacharjee H, Bharadwaj AP, Roy A, et al. Emergence of multidrug-resistant Vibrio cholerae O1 Biotype El Tor in Port Blair, India. Am J Trop Med Hyg. 2012;86:1015-7.

Dey S, Parande MV, Parande AM, Lakkannavar SL, Rathore PK, Mantur BG, et al. Twin outbreak of cholera in rural North Karnataka, India. Indian J Med Res. 2014;140:420-6.

Centers for Disease Control and Prevention. Cholera- Vibrio Cholerae Infection. Recommendations for the Use of Antibiotics for the Treatment of Cholera. Cited 2016 May 1. Available at: http://www.cdc.gov/cholera/treatment/antibiotic-treatment.html#twentyone.

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Published

2017-01-05

How to Cite

Nandimath, V. A., Nandimath, S. A., Swamy, C. S., & Ukrande, A. R. (2017). Epidemiological study of drug resistant cholera in and around Miraj, India. International Journal Of Community Medicine And Public Health, 3(8), 2058–2063. https://doi.org/10.18203/2394-6040.ijcmph20162546

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Original Research Articles