Relation between serum uric acid and diabetes type II

Ghadeer Banjar, Hanadi Abdulrahim, Jawaher Alomari, Reem Aldeijy, Azzam Almalki, Sultan Alrabghi, Rawan AlMuhanna, Abdulhamid ALAMA, Anwar Albalawi, Osama Almazrui


Incidence of diabetes mellitus type 2 has been increasing worldwide, making the disease of extreme importance. Several reports have suggested a possible association between serum levels of uric acid (SUA) and higher incidence of diabetes mellitus type 2. On a biological basis, uric acid can negatively affect insulin resistance in animals. This occurs due to the inhibition of nitric oxide which is crucial to achieve glucose uptake. In this study, we aim to: report on previous literature on relation between serum uric acid and diabetes type II in Saudi and prevalence of association between them. PubMed database and EBSCO Information Services were used for articles selection. All relevant articles to our review with the topics regarding the relation between serum uric acid and diabetes type II, and other articles have been used. We excluded other articles, which are not related to this field. The data will be extracted according to specific form in which it is going to be reviewed by the group members.
In this meta-analysis we found that SUA levels positively correlate with diabetes mellitus type 2. Future studies should try to determine the reliability of using SUA levels to predict diabetes mellitus type 2 and improve prevention.


Uric acid, Diabetes mellitus type II, Saudi Arabia

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Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94:311–21.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.

Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2011;63:102-10.

Li L, Yang C, Zhao Y, Zeng X, Liu F, Fu P. Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: A systematic review and meta-analysis based on observational cohort studies. BMC Nephrol. 2014;15:122.

Lv Q, Meng XF, He FF, Chen S, Su H, Xiong J. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PLoS One. 2013;8:e56864.

Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, Krotova K, Block ER, Prabhakar S, Johnson RJ. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67:1739–42.

Quinones Galvan A, Natali A, Baldi S, Frascerra S, Sanna G, Ciociaro D, Ferrannini E. Effect of insulin on uric acid excretion in humans. Am J Physiol. 1995;268:1–5.

Fox IH. Metabolic basis for disorders of purine nucleotide degradation. Metabolism. 1981;30:616–34.

Kodama S, Saito K, Yachi Y. Association Between Serum Uric Acid and Development of Type 2 Diabetes. Diabetes Care. 2009;32(9):37-42.

Chien KL, Chen MF, Hsu HC, Chang WT, Su TC, Lee YT, Hu FB. Plasma uric acid and the risk of type 2 diabetes in a Chinese community. Clin Chem. 2008;54(2):310-6.

Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K. Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. Eur J Epidemiol. 2003;18(6):523-30.

Wang T, Bi Y, Xu M. Serum uric acid associates with the incidence of type 2 diabetes in a prospective cohort of middle-aged and elderly Chinese. Endocrine. 2011;40:109-16.

Singh PP, Mahadi F, Roy A. Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2. Indian J Clin Biochem. 2009;24:324.

Xue B, Tan JB, Ning F, Sun JP, Zhang KY, Liu L, et al. Association between serum uric acid and prevalence of type 2 diabetes diagnosed using HbA1c criteria among Chinese adults in Qingdao, China. Bio Environ Sci. 2015;28:884–93.

Qiu Q, Gong Y, Liu X, Dou L, Wang Y, Wang B, et al. Serum Uric Acid and Impaired Glucose Tolerance: The Cardiometabolic Risk in Chinese (CRC) Study. Cell Biochem Biophys. 2015;73:155.

Sluijs I, Beulens JWJ, van der ADL, Spijkerman AMW, Schulze MB, van der Schouw YT. Plasma Uric Acid Is Associated with Increased Risk of Type 2 Diabetes Independent of Diet and Metabolic Risk Factors. J Nutrition. 2013;143:80–5.

Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006;290:625–31.

Reungjui S, Roncal CA, Mu W, Srinivas TR, Sirivongs D. Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J Am Soc Nephrol. 2007;18:2724–31.

Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67:1739–42.

Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003;41:1183–90.

Butler R, Morris AD, Belch JJ, Hill A, Struthers AD. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension. 2000;35:746–51.

Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol. 2007;293:584–96.

Onat A, Uyarel H, Hergenç G, Karabulut A, Albayrak S, Sari I. Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens. 2006;19:1055-62.

Taniguchi Y, Hayashi T, Tsumura K, Endo G, Fujii S, Okada K. Serum uric acid and the risk for hypertension and type 2 diabetes in Japanese men: the Osaka Health Survey. J Hypertens. 2001;19:1209-15.

Dehghan A, van Hoek M, Sijbrands EJ. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008;31:361–2.

Fouad M. Serum uric acid and its association with hypertension, early nephropathy and chronic kidney disease in type 2 diabetic patients. J Bras Nefrol. 2016;38:403-10.

Bandaru P, Shankar A. Association between Serum Uric Acid Levels and Diabetes Mellitus. International J Endocrinol. 2011:604715.

Bhole V. Serum Uric Acid Levels and the Risk of Type 2 Diabetes: A Prospective Study. American J Med. 2010;123(10):957–61.

Niskanen L, Laaksonen D E, Lindstrom J. Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance: the Finnish Diabetes Prevention Study. Diabetes Care. 2006;29:709–11.

Kramer CK, von Muhlen D, Jassal SK. Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: the Rancho Bernardo Study. Diabetes Care. 2009;32:1272–3.