A cross sectional study on adequacy of blood transfusion and transfusion related infections in thalassemic patients attending a medical college hospital, West Bengal
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20183105Keywords:
Thalassemia, Ferritin level, Transfusion related infectionsAbstract
Background: Thalassemia is more prevalent in India. The main treatment of Thalassemia is blood transfusion. But the transfusion of blood has many side effects like iron overload, transfusion related infections etc. The objectives of the study were to assess the adequacy of blood transfusion for thalassemic patients and to determine the magnitude of transfusion transmitted infections among those patients.
Methods: A cross sectional study was conducted in Murshidabad Medical College and Hospital, West Bengal for 1 month with the sample size of 116. The blood samples from the patients were taken from the patients attending for blood transfusion in transfusion centre of Murshidabad Medical College and Hospital for two weeks dated from 24.04.2017 to 05.05.2017 to check for the hemoglobin, ferritin level and hepatitis B, C and HIV infection.
Results: Among the 116 patients, even after transfusion, 94% of the study participants have their hemoglobin levels below 7 gm/dl. Only 2 individuals got their hemoglobin levels more than 9 gm/dl and only 1 patient got HIV infection post transfusion which accounts for 0.9% of study population.
Conclusions: Frequent Hb estimation will help to maintain the adequacy of blood transfusion and proper screening of the blood before transfusion can help in reducing these transfusion transmitted infections.
References
Hossain MS, Raheem E, Sultana TA, Ferdous S, Nahar N, Islam S, et al. Thalassemias in South Asia: clinical lessons learnt from Bangladesh. Orphanet journal of rare diseases. 2017;12(1):93.
Central Intelligence Agency. The World Factbook 2016. Washington, DC: Central Intelligence Agency; 2016. Available at: https://www.cia.gov/ library/publications/resources/the-world-factbook/geos/gt.html.
Grow K, Vashist M, Abrol P, Sharma S, Yadav R. Beta thalassemia in India: current status and the challenges ahead. Int J Pharm Pharm Sci. 2014;6(4):28-33.
Mohanty D, Colah RB, Gorakshakar AC, Patel RZ, Master DC, Mahanta J, et al. Prevalence of beta-thalassemia and other haemoglobinopathies in six cities in India: a multicentre study. J Community Genet. 2013;4(1):33-42.
Balgir RS. The burden of hemoglobinopathies in India and the challenges ahead. Curr Sci. 2000;79:1536-47.
Verma IC, Choudhury VP, Jain PK. Prevention of thalassemia: A necessity in India. Indian J Pediatr. 1992;59:649-54.
Brittenham GM, Griffith PM, Nienhuis AW, McLaren CE, Young NS, Tucker EE, et al. Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med. 1994;331:567-73.
Thalassemia International Federation: Guidelines for the clinical management of thalassemia. Available at: http://www.thalassaemia.org.cy/ Publications.htm. Accessed on 23 September 2004.
Gattermann N. Guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload. Leuk Res. 2007;31:S10-5.
Shah N, Mishra A, Chauhan D, Vora C, Shah NR. Study on effectiveness of transfusion program in thalassemia major patients receiving multiple blood transfusions at a transfusion centre in Western India. Asian J Transfus Sci. 2010;4(2):94-8.
Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV. HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol. 2001;44:409-12.
Sing B, Verma M, Verma K. Markers for transfusion associated hepatitis in north Indian blood donors: prevalence and trends. Jpn J Infect Dis. 2004;57:49-51.
Makroo RN, Sahil P, Vashist RP, Lal S. Trends of HIV infection in blood donors of Delhi. Indian J Pathol Microbiol. 1996;39:139-42.
Srikrishna A, Sitalaxmi S, Prema Damodar S. How safe are our safe donors? Indian J Pathol Microbiol. 1999;42:411-6.