Change in body weight and treatment outcome in sputum positive pulmonary tuberculosis patients treated under directly observed treatment short-course

Authors

  • Malangori A. Parande Department of Preventive and Social Medicine, B.J. Govt. Medical College, Pune, Maharashtra
  • Pradip S. Borle Department of Preventive and Social Medicine, B.J. Govt. Medical College, Pune, Maharashtra
  • Vinay S. Tapare Department of Preventive and Social Medicine, B.J. Govt. Medical College, Pune, Maharashtra
  • Sudhakar W. More State Tuberculosis Training and Demonstration Centre (STDC), Pune, Maharashtra
  • Susmita S. Bhattacharya Department of Preventive and Social Medicine, B.J. Govt. Medical College, Pune, Maharashtra

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20182172

Keywords:

Weight gain after treatment, Sputum smear grading, Tuberculosis, Adherence to treatment

Abstract

Background: Patients with tuberculosis often suffer from severe weight loss and is used as useful marker to predict TB treatment outcome. Hence a study was planned with an objective to determine the change of patient’s body weight over time throughout treatment and to determine whether there was any association with treatment outcome.

Methods: This was a retrospective cohort study, planned to be conducted among all smear positive pulmonary tuberculosis patients registered in a Tuberculosis Unit of Pune corporation, during the period of January to December 2015. Body weights of patients were recorded from TB treatment cards at the time of diagnosis, after 2 months of intensive phase of treatment and at the end of treatment. Total 344 cases were enrolled. Chi-Square test and Fisher’s exact test and repeated measure ANOVA test was used for analysis.

Results: A bad outcome was more likely among the category II cases as compared to category I, among non-adherent to treatment cases in continuation phase and higher sputum grading at the time of diagnosis i. e. in 3+ sputum smear grading. The weights of the patients at the time of diagnosis, at end of intensive phase and at end of treatment showed statistical significant difference (p<0.0001). The weight gain, more so at end of treatment was significantly associated with good outcome.

Conclusions: Weight gain has prognostic significance in patients with tuberculosis and should be considered as a surrogate marker to monitor response to TB treatment especially in developing countries where extensive laboratory tests are not feasible. 

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Published

2018-05-22

How to Cite

Parande, M. A., Borle, P. S., Tapare, V. S., More, S. W., & Bhattacharya, S. S. (2018). Change in body weight and treatment outcome in sputum positive pulmonary tuberculosis patients treated under directly observed treatment short-course. International Journal Of Community Medicine And Public Health, 5(6), 2431–2436. https://doi.org/10.18203/2394-6040.ijcmph20182172

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Original Research Articles