Risk factors of dementia: a comparative study among the geriatric age group in Ernakulam, Southern India
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20180117Keywords:
Dementia risk factors, Geriatrics, Case control, South IndiaAbstract
Background: Dementia is the global deterioration of the individual’s intellectual, emotional and cognitive faculties in a state of normal consciousness. Dementia impacts personal, family and societal life. It reduces life span, induces caregiver’s strain at family level and over utilizes health care facility. This study was aimed at describing the risk factors attributing to dementing disorders for developing preventive measures to slow down the incidence of dementia.
Methods: The study was conducted in geriatrics OPD of a tertiary hospital in South India. A total of 50 dementia patients and 50 controls aged more than 65 years were selected for the study in a period of 6 months. A semi-structured questionnaire was used to collect data.
Results: 40% in the age group of 65-74 years, 61% in the age group of 75-84 years and 63.6% in the age >85 years had dementia. 43.5% of males and 55.5% of females had dementia. Multivariate analysis was done to find out the independent predictors of dementia. Among the morbidities dyslipidemia 3.93 (1.12-13.87) and COPD/bronchial asthma 4.57 (1.02-20.55), less than 5 days of fruit consumption 14.98 (38-59), hearing loss 4.67 (1.15-18.91) were found to be independent risk factors for dementia. Living alone was found to be a protective factor 0.029 (0.003-0.29).
Conclusions: Our study reported various risk factors of dementia that were in agreement with findings from other studies conducted in India. Avoidable risk factors such as living alone, fruit intake and control of comorbidities such as hypertension, dyslipidemia and COPD/bronchial asthma needs more attention in old age group.
References
WHO. WHO: Dementia. World health organization; 2017. Available at: http://www.who.int/media-centre/factsheets/fs362/en/. Accessed on 5 January 2018.
Kant S, Singh T, Poddar K, Singh A. An epidemiological study of dementia among the habitants of Eastern Uttar Pradesh, India. Ann Indian Acad Neurol. 2011;14(3):164.
Das S, Ghosal M, Pal S. Dementia: Indian scenario. Neurol India. 2012;60(6):618.
Das SK, Bose P, Biswas A, Dutt A, Banerjee TK, Hazra A, et al. An epidemiologic study of mild cognitive impairment in Kolkata, India. Neurology. 2007;68(23):2019–26.
Miranda-Castillo C, Woods B, Orrell M. People with dementia living alone: what are their needs and what kind of support are they receiving? Int Psychogeriatr. 2010;22(04):607–17.
Singleton D, Mukadam N, Livingston G, Sommerlad A. How people with dementia and carers understand and react to social functioning changes in mild dementia: a UK-based qualitative study. BMJ Open. 2017;7(7):e016740.
Feldman L, Wilcock J, Thuné-Boyle I, Iliffe S. Explaining the effects of symptom attribution by carers on help-seeking for individuals living with dementia. Dementia. 2017;16(3):375–87.
Lin H-R, Otsubo T, Imanaka Y. Survival analysis of increases in care needs associated with dementia and living alone among older long-term care service users in Japan. BMC Geriatr. 2017;17(1):182.
Eichler T, Hoffmann W, Hertel J, Richter S, Wucherer D, Michalowsky B, et al. Living Alone with Dementia: Prevalence, Correlates and the Utilization of Health and Nursing Care Services. Monastero R, editor. J Alzheimers Dis. 2016;52(2):619–29.
Luchsinger JA, Noble JM, Scarmeas N. Diet and Alzheimer’s disease. Curr Neurol Neurosci Rep. 2007;7(5):366–72.
Martin A, Cherubini A, Andres-Lacueva C, Paniagua M, Joseph J. Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance. J Nutr Health Aging. 2002;6(6):392–404.
Kalaria R, Gladys EM, Arizaga R, Friedland RP, Galasko D, Hall K, et al. Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol. 2008;7(9):812-26.
Shaji S, Bose S, Verghese A. Prevalence of dementia in an urban population in Kerala, India. Br J Psychiatry. 2005;186(02):136–40.
Thomson RS, Auduong P, Miller AT, Gurgel RK. Hearing loss as a risk factor for dementia: A systematic review: Hearing Loss and Dementia Systematic Review. Laryngoscope Investig Otolaryngol. 2017;2(2):69–79.
Lin FR, Metter EJ, O’Brien RJ, Resnick SM, Zonderman AB, Ferrucci L. Hearing Loss and Incident Dementia. Arch Neurol. 2011;68(2):214-20.
Samuel R, McLachlan CS, Mahadevan U, Isaac V. Cognitive impairment and reduced quality of life among old-age groups in Southern Urban India: home-based community residents, free and paid old-age home residents. QJM. 2016;109(10):653–9.
Rajkumar S, Kumar S, Thara R. Prevalence of dementia in a rural setting: A report from India. Int J Geriatr Psychiatry. 1997;12(7):702–7.
Chandra V, Ganguli M, Pandav R, Johnston J, Belle S, DeKosky ST. Prevalence of Alzheimer’s disease and other dementias in rural India: The Indo-US study. Neurology. 1998;51(4):1000–8.
Vas CJ, Pinto C, Panikker D, Noronha S, Deshpande N, Kulkarni L, et al. Prevalence of dementia in an urban Indian population. Int Psychogeriatr. 2001;13(4):439–50.
Mathuranath PS, Cherian PJ, Mathew R, Kumar S, George A, Alexander A, et al. Dementia in Kerala, South India: prevalence and influence of age, education and gender. Int J Geriatr Psychiatry. 2010;25(3):290–7.
Zhang MY, Katzman R, Salmon D, Jin H, Cai GJ, Wang ZY, et al. The prevalence of dementia and Alzheimer’s disease in Shanghai, China: impact of age, gender, and education. Ann Neurol. 1990;27(4):428–37.
Sharp ES, Gatz M. Relationship Between Education and Dementia: An Updated Systematic Review. Alzheimer Dis Assoc Disord. 2011;25(4):289–304.