Emerging infectious diseases: MERS-COV, the new Betacoronavirus pandemic
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20180042Keywords:
Betacoronavirus, Emerging pandemic, MERS-CoVAbstract
Both the recent MERS-CoV and the past SARS-CoV indicate that new pathogens would probably emerge. Because it is not possible to predict when or where a new epidemic would occur, this continues to be a challenging issue for physicians and healthcare organizations. Furthermore, there are prophylactic vaccines or effective treatment for these infections and little is known about the origin and the zoonotic transmission of MERS-CoV which hinders the progress of its spread to humans. MERS-CoV is highly pathogenic, exhibiting high fatality rate than the former human corona virus SARS and can obviously be transmitted through several routes, with higher incidence in compromised healthcare settings. Currently, efforts to manage MERS-CoV spared should be directed towards developing educational programs, targeting the public and more importantly health care providers. For one major concern, this infection has and still could pose potential to spread rapidly across the globe, especially during religious mass gathering originating from a MERS-CoV hot spot (i.e., Hajj). Continued epidemiologic surveillance and vigilance remains crucial to compact this virus, or any future mutation.
References
Eyler JM. The changing assessments of John Snow’s and William Farr’s cholera studies. Soz Praventivmed. 2001;46(4):225-32.
Mooney G. Spreading germs: diseases, theories, and medical practice in Britain, 1865-1900 by Michael Worboys, book review. Hist Philos Life Sci. 2002;24(2):327-8.
Fauci AS. Infectious Diseases: Considerations for the 21st Century. Clin Infect Dis. 2001;32(5):675-85.
Johnson NPAS, Mueller J. Updating the accounts: global mortality of the 1918-1920 “Spanish” Influenza Pandemic. Bull Hist Med. 2002;76(1):105-15.
Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature. 2004;430(6996):242-9.
WHO. World Health Statistics. 2007: 2007.
Ksiazek TG, Erdman D, Goldsmith CS. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348(20):1953-66.
Banik GR, Khandaker G, Rashid H. Middle East Respiratory Syndrome Coronavirus “MERS-CoV”: Current Knowledge Gaps. Paediatr Respir Rev. 2015;16(3):197-202.
Pavli A, Tsiodras S, Maltezou HC. Middle East respiratory syndrome coronavirus (MERS-CoV): Prevention in travelers. Travel Med Infect Dis. 2014;12(6):602-8.
Meyer B, García-Bocanegra I, Wernery U, Wernery R, Sieberg A, Müller MA, et al. Serologic assessment of possibility for MERS-CoV infection in equids. Emerg Infect Dis. 2015;21(1):181-2.
Al-Tawfiq JA, Memish ZA. Middle East respiratory syndrome coronavirus: Transmission and phylogenetic evolution. Trends Microbiol. 2014;22(10):573-9.
AlBarrak AM, Stephens GM, Hewson R, Memish ZA. Recovery from severe novel coronavirus infection. Saudi Med J. 2012;33(12):1265-9.
Lelli D, Papetti A, Sabelli C, Rosti E, Moreno A, Boniotti MB. Detection of coronaviruses in bats of various species in Italy. Viruses. 2013;5(11):2679-89.
Alagaili AN, Briese T, Mishra N, Kapoor V, Sameroff SS, Burbelo PD, et al. Middle east respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia. MBio. 2014;5(2):e01002-14.
Hemida MG, Perera RA, Al Jassim RA, Kayali G, Siu LY, Wang P, et al. Seroepidemiology of middle east respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity. Euro Surveill. 2014;19(23):20828.
Azhar EI, El-Kafrawy SA, Farraj SA, Hassan AM, Al-Saeed MS, Hashem AM, et al. Evidence for Camel-to-Human Transmission of MERS Coronavirus. N Engl J Med. 2014;370(26):2499-505.
Han H-J, Yu H, Yu X-J. Evidence for zoonotic origins of Middle East respiratory syndrome coronavirus. J Gen Virol. 2016;97(2):274-80.
Hemida MG, Perera RA, Wang P, Alhammadi MA, Siu LY, Li M, et al. Middle east respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013. Euro Surveill. 2013;18(50):20659.
Guery B, Poissy J, El Mansouf L, Séjourné C, Ettahar N, Lemaire X, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: A report of nosocomial transmission. Lancet. 2013;381(9885):2265-72.
Lim PL, Lee TH, Rowe EK. Middle east respiratory syndrome coronavirus (MERS CoV): Update 2013. Curr Infect Dis Rep. 2013;15(4):295-8.
Hijawi B, Abdallat M, Sayaydeh A. Novel coronavirus infections in Jordan, April 2012: Epidemiological findings from a retrospective investigation. East Mediterr Heal J. 2013;19(1):12-8.
Assiri A, McGeer A, Perl TM. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013;369(5):407-16.
Oboho IK, Tomczyk SM, Al-Asmari AM. 2014 MERS-CoV Outbreak in Jeddah — A Link to Health Care Facilities. N Engl J Med. 2015;372(9):846-54.
Cowling BJ, Park M, Fang VJ, Wu P, Leung GM, Wu JT, et al. Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, may to june 2015. Euro Surveill. 2015;20(25):1-7.
World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV): summary and risk assessment of current situation in the Republic of Korea and China. Available at: http://www.who. int/emergencies/mers-cov/mers-cov- republic-of-korea-and-china-risk-assessment-19-june-2015.pdf?ua =1. Accessed on 19 June 2015.
Khalafalla AI, Lu X, Al-Mubarak AIA, Dalab AHS, Al-Busadah KAS, Erdman DD, et al. MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia, 2013–2014. Emerg Infect Dis. 2015;21(7):1153-8.
Reusken CBEM, Raj VS, Koopmans MP, Haagmans BL. Cross host transmission in the emergence of MERS coronavirus. Curr Opin Virol. 2016;16:55-62.
Park HY, Lee EJ, Ryu YW. Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, may to june 2015. Euro Surveill. 2015;20(25):1-5.
van Doremalen N, Bushmaker T, Munster VJ. Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions. Euro Surveill. 2013;18(38):1-4.
Drosten C, Meyer B, Müller MA. Transmission of MERS-Coronavirus in Household Contacts. N Engl J Med. 2014;371(9):828-35.
Al-Tawfiq JA, Omrani AS, Memish ZA. Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns. Front Med. 2016;10(2):111-9.
Shalhoub S, Farahat F, Al-Jiffri A. IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: A retrospective study. J Antimicrob Chemother. 2015;70(7):2129-32.
Lambeir A-M, Durinx C, Scharpé S, De Meester I. Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV. Crit Rev Clin Lab Sci. 2003;40(3):209-94.
Al-Tawfiq JA. Middle east respiratory syndrome-coronavirus infection: An overview. J Infect Public Health. 2013;6(5):319-22.
Arabi YM, Arifi AA, Balkhy HH. Clinical course and outcomes of critically ill patients with middle east respiratory syndrome coronavirus infection. Ann Intern Med. 2014;160(6):389-97.
Memish ZA, Al-Tawfiq JA, Makhdoom HQ. Respiratory tract samples, viral load, and genome fraction yield in patients with middle east respiratory syndrome. J Infect Dis. 2014;210(10):1590-1594.
Perera RA, Wang P, Gomaa MR. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill. 2013;18(36):205.
Otter JA, Donskey C, Yezli S, Douthwaite S, Goldenberg SD, Weber DJ et al. Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: The possible role of dry surface contamination. J Hosp Infect. 2016;92(3):235-50.
de Wilde AH, Raj VS, Oudshoorn D. MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment. J Gen Virol. 2013;94(8):1749-60.
Corti D, Zhao J, Pedotti M. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci. 2015;112(33):10473-8.