OriPro 2.0: a low-glycemic, high-protein peptide-based nutritional supplement for clinical nutrition support – current evidence and future perspectives
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20262772Keywords:
Enteral nutrition, Glycemic index, Medium chain triglycerides, Medical nutrition therapy, OriPro 2.0, Peptide-based nutrition, Whey protein hydrolysateAbstract
Disease related malnutrition remains a major problem in hospitalized and critical patients, contributing significantly to prolonged hospitalization; prone to susceptibility to infections, delayed wound healing, muscle wasting, and increased mortality. Optimizing nutritional therapy has therefore become an important component of multidisciplinary clinical care. High-protein, peptide based nutritional supplements have gained an attention because they are designed to improve nutrient absorption rate, preserve lean body mass, support gastrointestinal tolerance, and enhance metabolic recovery. Among these specialized formula supplementation, OriPro 2.0 is a high calorie, high protein, peptide based oral and enteral supplement formulated with whey protein hydrolysate, concentrated whey protein, medium-chain triglycerides, dietary fiber, prebiotics, vitamins and minerals. This review summarizes current scientific evidence regarding the nutritional composition, physiological function, glycemic characteristics, and potential clinical applications of OriPro 2.0. Particular importance is placed on the role of peptide based nutrition in critically ill patients, individuals with gastrointestinal dysfunction, postoperative patients, geriatrics with sarcopenia, and patients experiencing disease-related malnutrition. Available evidence indicates that peptide-based formulations improve protein digestion, amino acid absorption, nitrogen balance, and gastrointestinal tolerance compared with conventional polymeric formulas in particular patient populations. Furthermore, the glycemic index study of OriPro 2.0 showed a low GI value (36±5), suggesting that the formulation may contribute to improved postprandial glucose control while maintaining adequate caloric and protein intake. The combination of derived peptides from whey, complex carbohydrates, medium chain triglycerides, soluble fiber, and micronutrients provides strong physiological functions for its use in medical nutrition therapy. However, despite promising nutritional characteristics, direct clinical evidence evaluating OriPro 2.0 remains limited. Most available data supporting peptide-based nutrition originate from studies evaluating similar formulations rather than OriPro 2.0 itself. Large multicenter randomized controlled trials are therefore required to establish its efficacy, safety, cost effectiveness, and prolong clinical outcomes across varieties of patients. Overall, OriPro 2.0 represents a promising specialized nutritional supplement with potential applications in metabolic support and clinical nutrition. Future evidence-based investigations should determine its effectiveness in improving nutritional status, glycemic control, gastrointestinal tolerance, inflammatory responses, and functional recovery.
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References
Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, et al. GLIM criteria for the diagnosis of malnutrition. Clin Nutr. 2019;38(1):1-9.
Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient. Crit Care Med. 2016;44(2):390-438.
Barker LA, Gout BS, Crowe TC. Hospital malnutrition: prevalence, identification and impact on patients. Int J Environ Res Public Health. 2011;8:514-27. DOI: https://doi.org/10.3390/ijerph8020514
Mehta Y, Sunavala JD, Zirpe K, Tyagi N, Garg S, Sinha S, et al. Practice Guidelines for Nutrition in Critically Ill Patients: A Relook for Indian Scenario. Indian J Crit Care Med. 2018;22(4):263-73. DOI: https://doi.org/10.4103/ijccm.IJCCM_3_18
Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38:48-79.
McClave SA, Taylor BE, Martindale RG, Patel J, Rice TW, Braunschweig C, et al. Guidelines for nutrition support therapy in the adult critically ill patient. JPEN. 2016;40:159-211. DOI: https://doi.org/10.1177/0148607115621863
Alexander DD, Bylsma LC, Elkayam L, Nguyen DL. Nutritional and health benefits of semi-elemental diets. World J Gastrointest Pharmacol Ther. 2016;7:306-19.
Ibrahim H, Mansour M, El Gendy YG. Peptide-based formula versus polymeric formula for critically ill children. Arch Med Sci. 2020;16:592-6. DOI: https://doi.org/10.5114/aoms.2020.94157
Nguyen DL, Schott LL, Lowen CC, Desai AM, Baumer DL, Miranowski MK, et al. Characteristics and feeding intolerance in critically ill adult patients receiving peptide-based enteral nutrition. Clin Nutr ESPEN. 2024;59:270-8.
de Brito-Ashurst I, Preiser JC. Diarrhea in critically ill patients: the role of enteral feeding. JPEN. 2016;40:913-23. DOI: https://doi.org/10.1177/0148607116651758
Davies RW, Carson BP, Jakeman PM. Whey protein supplementation and recovery following resistance training: A systematic review. Nutrients. 2018;10:221.
Phillips SM. Nutritional supplements in support of resistance exercise. Sports Med. 2015;45:S123-40.
Wu Z, Liu J, Zhang D, Kang K, Zuo X, Xu Q, et al. Expert consensus on glycemic management of critically ill patients. J Intensive Med. 2022;2:131-45. DOI: https://doi.org/10.1016/j.jointm.2022.06.001
Dhatariya K, Corsino L, Umpierrez GE. Management of diabetes and hyperglycemia in hospitalized patients. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000.
Augustin LSA, Kendall CWC, Jenkins DJA, Willett WC, Astrup A, Barclay AW, et al. Glycemic index, glycemic load and glycemic response. Nutr Metab Cardiovasc Dis. 2015;25:795-815.
Singh N, Benjamin S. Glycemic index of a high protein, high calorie, peptide based nutrition formulation. Int J Food Nutr Sci. 2024;13(S4):499-509.
Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, et al. GLIM criteria for the diagnosis of malnutrition. Clin Nutr. 2019;38(1):1-9. DOI: https://doi.org/10.1016/j.clnu.2019.02.033
Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient. Crit Care Med. 2016;44(2):390-438. DOI: https://doi.org/10.1097/CCM.0000000000001525
Alexander DD, Bylsma LC, Elkayam L, Nguyen DL. Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature. World J Gastrointest Pharmacol Ther. 2016;7(2):306-19. DOI: https://doi.org/10.4292/wjgpt.v7.i2.306
Singh N, Benjamin S. Glycemic index of a high protein, high calorie, peptide based nutrition formulation. Int J Food Nutr Sci. 2024;13(S4):499-509.
OriPro 2.0 Product Information and Nutritional Label. Nucgnex Lifesciences Pvt Ltd. Available at: https://nucgnex.com/?srsltid=AfmBOopD8-gadc5h Qww221H4p6b7WNoIhWhJMQqrL53_r_eSuKP5TkCW. Accessed on 12 June 2026.
Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38(1):48-79. DOI: https://doi.org/10.1016/j.clnu.2018.08.037
Weijs PJM, Stapel SN, de Groot SDW, Driessen RH, de Jong E, Girbes AR, et al. Optimal protein and energy nutrition decreases mortality in mechanically ventilated critically ill patients. JPEN J Parenter Enteral Nutr. 2012;36(1):60-8. DOI: https://doi.org/10.1177/0148607111415109
Augustin LSA, Kendall CWC, Jenkins DJA, Willett WC, Astrup A, Barclay AW, et al. Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit. Nutr Metab Cardiovasc Dis. 2015;25(9):795-815. DOI: https://doi.org/10.1016/j.numecd.2015.05.005
Shah ND, Limketkai BN. The use of medium-chain triglycerides in gastrointestinal disorders. Pract Gastroenterol. 2017;41(1):20-8.
Eckel RH, Hanson AS, Chen AY, Berman JN, Yost TJ, Brass EP et al. Dietary substitution of medium-chain triglycerides improves insulin-mediated glucose metabolism in NIDDM subjects. Diabetes. 1992;41(5):641-7. DOI: https://doi.org/10.2337/diab.41.5.641
Davies RW, Carson BP, Jakeman PM. The effect of whey protein supplementation on the temporal recovery of muscle function following resistance training: A systematic review and meta-analysis. Nutrients. 2018;10(2):221. DOI: https://doi.org/10.3390/nu10020221
Phillips SM. Nutritional supplements in support of resistance exercise. Sports Med. 2015;45(Suppl 1):S123-40.
Churchward-Venne TA, Breen L, Di Donato DM, Hector AJ, Mitchell CJ, Moore DR, et al. Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men. Am J Clin Nutr. 2014;99(2):276-86. DOI: https://doi.org/10.3945/ajcn.113.068775
Gilbert ER, Wong EA, Webb KE Jr. Peptide absorption and utilization: Implications for animal nutrition and health. Nutr Res Rev. 2008;21(1):38-53.
Nguyen DL, Schott LL, Lowen CC, Desai AM, Baumer DL, Miranowski MK, et al. Characteristics and feeding intolerance in critically ill adult patients receiving peptide-based enteral nutrition. Clin Nutr ESPEN. 2024;59:270-8. DOI: https://doi.org/10.1016/j.clnesp.2023.12.007
Livesey G, Tagami H. Interventions to lower the glycemic response to carbohydrate foods. Br J Nutr. 2009;102(11):1541-8.
Roberfroid MB. Inulin-type fructans: Functional food ingredients. J Nutr. 2007;137(11 Suppl):2493-502. DOI: https://doi.org/10.1093/jn/137.11.2493S
FAO/WHO. Carbohydrates in Human Nutrition. Report of a Joint FAO/WHO Expert Consultation. Rome: FAO; 1998.
International Standards Organisation. ISO 26642:2010. Food products—Determination of the glycaemic index (GI) and recommendation for food classification. Geneva: ISO; 2010.
Elia M, Ceriello A, Laube H, Sinclair AJ, Engfer M, Stratton RJ. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: A systematic review and meta-analysis. Diabetes Care. 2005;28(9):2267-79. DOI: https://doi.org/10.2337/diacare.28.9.2267
Bach AC, Babayan VK. Medium-chain triglycerides: An update. Am J Clin Nutr. 1982;36(5):950-62. DOI: https://doi.org/10.1093/ajcn/36.5.950
Calder PC. Omega-3 fatty acids and inflammatory processes. Nutrients. 2010;2(3):355-74. DOI: https://doi.org/10.3390/nu2030355
Cara KC, Beauchesne AR, Wallace TC, Chung M. Safety of using enteral nutrition formulations containing dietary fiber in hospitalized critical care patients: A systematic review and meta-analysis. JPEN J Parenter Enteral Nutr. 2021;45(5):882-906.
Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell. 2016;165(6):1332-45. DOI: https://doi.org/10.1016/j.cell.2016.05.041
Slavin JL. Dietary fiber and body weight. Nutrition. 2005;21(3):411-8. DOI: https://doi.org/10.1016/j.nut.2004.08.018
Gombart AF, Pierre A, Maggini S. A review of micronutrients and the immune system. Nutrients. 2020;12(1):236. DOI: https://doi.org/10.3390/nu12010236
Brass EP. Supplemental carnitine and exercise. Am J Clin Nutr. 2000;72(2 Suppl):618S-23S. DOI: https://doi.org/10.1093/ajcn/72.2.618S
Schaffer SW, Kim HW. Effects and mechanisms of taurine as a therapeutic agent. Biomol Ther (Seoul). 2018;26(3):225-41. DOI: https://doi.org/10.4062/biomolther.2017.251
Zeisel SH, da Costa KA. Choline: An essential nutrient for public health. Nutr Rev. 2009;67(11):615-23. DOI: https://doi.org/10.1111/j.1753-4887.2009.00246.x
Cara KC, Beauchesne AR, Wallace TC, Chung M. Safety of using enteral nutrition formulations containing dietary fiber in hospitalized critical care patients: A systematic review and meta-analysis. JPEN J Parenter Enteral Nutr. 2021;45(5):882-906. DOI: https://doi.org/10.1002/jpen.2210
Liu T, Wang C, Wang Y, Wang LL, Ojo O, Feng QQ, et al. Effect of dietary fiber on gut barrier function, gut microbiota, short-chain fatty acids, inflammation, and clinical outcomes in critically ill patients: A systematic review and meta-analysis. JPEN J Parenter Enteral Nutr. 2022;46(5):997-1010. DOI: https://doi.org/10.1002/jpen.2319
Zaman MK, Chin KF, Rai V, Majid HA. Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis. World J Gastroenterol. 2015;21(17):5372-81. DOI: https://doi.org/10.3748/wjg.v21.i17.5372
So D, Whelan K, Rossi M. The prebiotic potential of inulin-type fructans: A systematic review. Adv Nutr. 2022;13(2):492-529. DOI: https://doi.org/10.1093/advances/nmab119
Xie Y, Gou L, Peng M, Zheng J, Chen L. Effects of soluble fiber supplementation on glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2021;40(4):1800-10. DOI: https://doi.org/10.1016/j.clnu.2020.10.032
Singh N, Benjamin S. Glycemic Index of a High Protein, High Calorie, Peptide Based Nutrition Formulation. Int J Food Nutr Sci. 2024;13(S4):499-509.
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