Punicalagin from pomegranate: a polyphenolic modulator of inflammation and cartilage homeostasis in knee and joint pain

Aavrati Rastogi; Roop B. Kalia; Pradeep K. Meena; Mukesh Bairwa

doi:10.18203/2394-6040.ijcmph20262774

Authors

Aavrati Rastogi Department of Orthopedics, AIIMS Rishikesh, Uttarakhand, India https://orcid.org/0000-0002-8985-3143
Roop B. Kalia Department of Orthopedics, AIIMS Rishikesh, Uttarakhand, India https://orcid.org/0000-0002-3418-5942
Pradeep K. Meena Department of Orthopedics, AIIMS Rishikesh, Uttarakhand, India https://orcid.org/0000-0001-7278-3671
Mukesh Bairwa Department of Internal Medicine, AIIMS Rishikesh, Uttarakhand, India https://orcid.org/0000-0002-8974-5775

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20262774

Keywords:

Punicalagin, Pomegranate, Cartilage homeostasis

Abstract

Knee osteoarthritis is increasingly recognized as a multifactorial disorder rather than simple “wear and tear.” Pain and cartilage degradation are caused by oxidative stress, metabolic imbalance, and chronic low-grade inflammation. NF κB is a significant therapeutic target because it is a key regulator of inflammation which promotes the production of cytokines and matrix breakdown.

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References

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