Urolithin A-induced mitophagy: a mitochondrial therapeutic axis for decelerating musculoskeletal aging and modulating knee osteoarthritis pain
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20263245Keywords:
Urolithin A, Mitophagy, Knee osteoarthritis, Mitochondrial dysfunction, Aging, Cellular senescence, Musculoskeletal rehabilitationAbstract
Knee osteoarthritis (OA) is a disease characterized by cellular energy dysregulation, in which structural joint deterioration and chronic pain are caused by mitochondrial dysfunction. OA is now recognized as a multifactorial condition caused by disturbed cellular homeostasis, metabolic imbalance, and typical biological processes of aging, notably mitochondrial dysfunction. However, it was once thought to be caused by mechanical wear and cartilage degradation
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