Factors affecting AEFI reporting among vaccine recipients in Oyo State, Nigeria
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20261009Keywords:
AEFI reporting, Vaccine recipients, Vaccine safetyAbstract
Background: Immunization has proved to be a worthy investment in reduction of morbidity and mortality related to vaccine preventable diseases. However, AEFI may deter people from assessing vaccines, leading to poor vaccine coverage and non achievement of herd immunity sufficient to break disease transmission. Despite the established vaccine safety framework, there are gaps in the reported cases of AEFI, whether by community members to health-system or HWs to the data-system.
Methods: This descriptive cross sectional study aimed at providing some answers to the missing aspect of AEFI reporting from the populace by conducting interview for 422 vaccine recipients from 3 randomly selected LGAs, 1 each from the 3 senatorial district in Oyo-State, Nigeria. Structured questionnaire was used in data collection and analysis was done with data subjected to descriptive (mean, range, standard deviation) and inferential (Chi-square (X2) and logistic regression) statistical analyses.
Results: The study demonstrated the odds of likelihood to report AEFI to be 38 times more in persons with good awareness about AEFI reporting compared to those without. Poor health workers support/reactions to previously reported AEFI cases influenced future reporting by community members negatively, resulting to lesser likelihood to report. The community member who reported that based on their experience, AEFI management cost was borne by the cases and that HWs dismiss complaints about AEFI as unnecessary report, were seen to be less likely to report AEFI.
Conclusions: Good awareness about the reporting system, perception about vaccine safety and satisfactory memorable experience are important at ensuring optimal AEFI reporting.
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References
Lindstrand A, Cherian T, Chang-Blanc D, Feikin D, O’Brien KL. The world of immunization: achievements, challenges, and strategic vision for the next decade. J Infect Dis. 2021;224:S452-67. DOI: https://doi.org/10.1093/infdis/jiab284
Cepal N. The 2030 agenda and the sustainable development goals: an opportunity for Latin America and the Caribbean. Goals, targets and global indicators; 2019
Etamesor S, Ottih C, Salihu IN, Okpani AI. Data for decision making: using a dashboard to strengthen routine immunisation in Nigeria. BMJ Glob Health. 2018;3:e000807. DOI: https://doi.org/10.1136/bmjgh-2018-000807
Galadima AN, Zulkefli NAM, Said SM, Ahmad N. Factors influencing childhood immunisation uptake in Africa: a systematic review. BMC Public Health. 2021;21:1-20. DOI: https://doi.org/10.1186/s12889-021-11466-5
Hobani F, Alhalal E. Factors related to parents’ adherence to childhood immunization. BMC Public Health. 2022;22:819. DOI: https://doi.org/10.1186/s12889-022-13232-7
Balgovind P, Mohammadnezhad M. Factors affecting childhood immunization: Thematic analysis of parents and healthcare workers’ perceptions. Hum Vaccines Immunother. 2022;18:2137338. DOI: https://doi.org/10.1080/21645515.2022.2137338
Abegunde D, Orobaton N, Sadauki H, Bassi A, Kabo IA, Abdulkarim M. Countdown to 2015: tracking maternal and child health intervention targets using lot quality assurance sampling in Bauchi state Nigeria. PLoS One. 2015;10:e0129129. DOI: https://doi.org/10.1371/journal.pone.0129129
Nigeria Multiple Indicator Cluster Survey (MICS) and National Immunization Coverage Survey (NICS) Survey Findings Report August 2022. Available from: https://www.unicef.org/nigeria/ media/6316/file/2021%20MICS%20full%20report%20.pdf. Accessed on 6 December 2025.
Bangura JB, Xiao S, Qiu D, Ouyang F, Chen L. Barriers to childhood immunization in sub-Saharan Africa: a systematic review. BMC Public Health. 2020;20:1-15. DOI: https://doi.org/10.1186/s12889-020-09169-4
Laryea EB, Frimpong JA, Noora CL, Tengey J, Bandoh D, Sabblah G, et al. Evaluation of the adverse events following immunization surveillance system, Ghana, 2019. PloS One. 2022;17:e0264697. DOI: https://doi.org/10.1371/journal.pone.0264697
Kiguba R, Olsson S, Waitt C. Pharmacovigilance in low‐and middle‐income countries: a review with particular focus on Africa. Br J Clin Pharmacol. 2023;89:491-509. DOI: https://doi.org/10.1111/bcp.15193
Mihigo R, Okeibunor J, Anya B, Mkanda P, Zawaira F. Challenges of immunization in the African Region. Pan Afr Med J. 2017;27. DOI: https://doi.org/10.11604/pamj.supp.2017.27.3.12127
Uppsala Monitoring Centre. Analytic in vigiLyze. Available from: https://www.who-umc.org/vigibase/vigilyze/. Accessed on 6 December 2025.
Akanmori BD, Traore T, Balakrishnan M, Maure C, Zuber P, Mihigo R. Vaccine safety and pharmacovigilance in the African region: recent updates. J Immunol Sci. 2018 DOI: https://doi.org/10.29245/2578-3009/2018/si.1112
Yamoah P, Bangalee V, Oosthuizen F. Knowledge and perceptions of adverse events following immunization among healthcare professionals in Africa: a case study from Ghana. Vaccines. 2019;7:28. DOI: https://doi.org/10.3390/vaccines7010028
Gidudu JF, Shaum A, Dodoo A, Bosomprah S, Bonsu G, Amponsah-Achiano K, et al. Barriers to healthcare workers reporting adverse events following immunization in four regions of Ghana. Vaccine. 2020;38(5). DOI: https://doi.org/10.1016/j.vaccine.2019.11.050
Olsson S, Pal SN, Dodoo A. Pharmacovigilance in resource-limited countries. Expert Rev Clin Pharmacol. 2015;8(4):449-60. DOI: https://doi.org/10.1586/17512433.2015.1053391
Breugelmans JG, Lewis RF, Agbenu E, Veit O, Jackson D, Domingo C, et al. Adverse events following yellow fever preventive vaccination campaigns in eight African countries from 2007 to 2010. Vaccine. 2013;31(14):1819-29. DOI: https://doi.org/10.1016/j.vaccine.2013.01.054
Ouandaogo CR, Yaméogo TM, Diomandé FV, Sawadogo C, Ouédraogo B, Ouédraogo-Traoré R, et al. Adverse events following immunization during mass vaccination campaigns at first introduction of a meningococcal A conjugate vaccine in Burkina Faso, 2010. Vaccine. 2012;30(2):B46-51. DOI: https://doi.org/10.1016/j.vaccine.2011.12.112
Omoleke SA, Bamidele M, De Kiev LC. Barriers to optimal AEFI surveillance and documentation in Nigeria: Findings from a qualitative survey. PloS Glob Public Health. 2023;3(9):e0001658. DOI: https://doi.org/10.1371/journal.pgph.0001658
Akwataghibe NN, Ogunsola EA, Broerse JE, Popoola OA, Agbo AI, Dieleman MA. Exploring factors influencing immunization utilization in Nigeria- a mixed methods study. Front Public Health. 2019;7:39. DOI: https://doi.org/10.3389/fpubh.2019.00392
Malande OO, Munube D, Afaayo RN, Chemweno C, Nzoka M, Kipsang J, et al. Adverse events following immunization reporting and impact on immunization services in informal settlements in Nairobi, Kenya: a prospective mixed-methods study. Pan Afr Med J. 2021;40.
Adubi KO, Oyundoyin BM, Ariyo AM, Adekunbi R, Lasode AO. Nursing mothers: Adverse events following immunization and its implication for counselling. Nursing. 2023;3.
Ophori EA, Tula MY, Azih AV, Okojie R, Ikpo PE. Current trends of immunization in Nigeria: prospect and challenges. Trop Med Health. 2014;42:67-75. DOI: https://doi.org/10.2149/tmh.2013-13
De Jonge A. Support for teenage mothers: a qualitative study into the views of women about the support they received as teenage mothers. J Adv Nurs. 2001;36:49-57. DOI: https://doi.org/10.1046/j.1365-2648.2001.01942.x
Osarfo J, Ampofo GD, Tagbor HK. Health seeking behaviour of caregivers of children under five and its determinants in Ho West and Adaklu districts, Volta Region, Ghana: a community-based cross-sectional study. BMC Public Health. 2025;25:1219. DOI: https://doi.org/10.1186/s12889-025-22393-0
Parrella A, Gold M, Braunack-Mayer A, Baghurst P, Marshall H. Consumer reporting of adverse events following immunization (AEFI): identifying predictors of reporting an AEFI. Hum Vaccine Immunother. 2014;10(3):747-54. DOI: https://doi.org/10.4161/hv.27459
Al Dweik R, Stacey D, Kohen D, Yaya S. Factors affecting patient reporting of adverse drug reactions: a systematic review. Br J Clin Pharmacol. 2017;83:875-83. DOI: https://doi.org/10.1111/bcp.13159