A case of Guillain-Barré syndrome in a 24-year-old man
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20261443Keywords:
Autoimmune disease of the nervous system, Autoimmune neuropathy, Guillain-Barré syndrome, Young adultAbstract
Guillain-Barré syndrome (GBS) is an acute, immune-mediated neurological disorder that affects approximately 1.2 to 2.3 individuals per 100,000 population annually, with notable regional and seasonal variations. In recent years, an increase in reported cases in certain regions of India has highlighted its emerging public health significance. GBS is characterized by rapid onset of muscle weakness and can progress to severe paralysis if not promptly managed. Early diagnosis and timely therapeutic interventions, such as immunotherapy and supportive care, are essential to improve patient outcomes and reduce the risk of long-term disability. This case report describes a 24-year-old male diagnosed with severe motor axonal polyneuropathy, a variant of GBS associated with more aggressive progression. Following a thorough clinical evaluation and diagnostic investigations, the patient was initiated on plasmapheresis. Currently, his condition is stable, with no further neurological deterioration, indicating a positive response to treatment and ongoing medical management.
References
Willison HJ, Jacobs BC, Van Doorn PA. Guillain-Barré syndrome. The Lancet. 2016;388(10045):717-27.
Yuki N, Hartung HP. Guillain–Barré syndrome. N Engl J Med. 2012;366(24):2294-304.
Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, et al. Diagnosis and management of Guillain–Barré syndrome in ten steps. Nat Rev Neurol. 2019;15(11):671-83.
Hay SI, Ong KL, Santomauro DF, AB, Aalipour MA, Aalruz H, et al. Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet. 2025;406(10513):1873-922.
Asbury AK, Arnason BG, Adams RD. The inflammatory lesion in idiopathic polyneuritis. Medicine. 1969;48(3):173.
Griffin JW, Li CY, Macko C, Ho TW, Hsieh ST, Xue P, et al. Early nodal changes in the acute motor axonal neuropathy pattern of the Guillain-Barré syndrome. J Neurocytol. 1996;25(1):33-51.
Islam Z, Jacobs BC, Van Belkum A, Mohammad QD, Islam MB, Herbrink P, et al. Axonal variant of Guillain-Barre syndrome associated with Campylobacter infection in Bangladesh. Neurology. 2010;74(7):581-7.
Bragazzi NL, Kolahi AA, Nejadghaderi SA, Lochner P, Brigo F, Naldi A, et al. Global, regional, and national burden of Guillain–Barré syndrome and its underlying causes from 1990 to 2019. J Neuroinflamm. 2021;18(1):264.
Singh A. Guillain-Barré syndrome in India: an epidemiological perspective - Medic Earth. Med Earth. 2025.
Watchdoq. GBS Alert: Cases rising in Pune and across India. Watchdoq: Trusted Healthcare Blog. 2025. Available at: https://watchdoq.com/ blog/post/gbs-alert:-cases-rising-in-pune-and-across-india-(feb-2025). Accessed on 06 December 2025.
Tatikonda CM, Juvvadi KR, Panda S, Mishra SB, Dash A. Miller Fisher Variant of Guillain-Barre Syndrome Secondary to Pulmonary Tuberculosis: A Case Report with Review of Literature. J Neuroanaesth Crit Care. 2023;10(2):128-31.
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