COVID-19 and its resurgence, public behavior, and global response: lessons learnt

Authors

  • Ishan Sinha Raffles Institution, Singapore
  • Aditya Pandey Dulwich College, Singapore

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20254066

Keywords:

COVID-19, Mutation, Vaccines, Omicron, Delta

Abstract

COVID-19 has caused significant damage to the social, emotional, and economic well-being of populations worldwide. Recent resurgences in several countries necessitate a focused review of the factors driving repeated waves of infection. This narrative review examines the evolution of the virus over time, behaviours of the public, and how governments implemented policies and systems to counter COVID-19. Key topics include the evolution of SARS‑CoV‑2 variants, the role of human behaviour in transmission, and the effectiveness and limitations of vaccines against rapidly evolving lineages. The review suggests that although vaccines have played a crucial role in mitigating the severity of symptoms and the spread of the virus, their effectiveness may decline over time due to waning immunity and the emergence of rapid viral mutations and newer strains. Moreover, asymptomatic infections can also exacerbate the spread of the virus without being recognized. Other social factors, including the spread of misinformation and behavioural complacency due to pandemic fatigue, also lead to an increase in the number of COVID cases. In 2025, given the emergence of new variants and the evolution of vaccines, this topic remains highly relevant. Understanding these patterns can help improve public health decisions and preparedness for future pandemics.

Metrics

Metrics Loading ...

References

Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91(1):157-60.

WHO. COVID-19 Cases, World. 2025. Available at: https://data.who.int/dashboards/covid19/cases. Accessed on 13 September 2025.

Planas D, Staropoli I, Michel V, Frederic L, Flora D, Matthieu P, et al. Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion. Nat Commun. 2024;15(1):2254. DOI: https://doi.org/10.1038/s41467-024-46490-7

Madzokere Eugene. What’s the difference between mutations, variants and strains? Royal Australian College of General Practioners. 2021. Available at: https://www1.racgp.org.au/newsgp/clinical/what-s-the-difference-between-mutations-variants-a. Accessed on 13 September 2025.

Katella K. Omicron, Delta, Alpha, and More: What to Know About the Coronavirus Variants. Yale Medicine. 2023.

Chaudhary FA, Khattak O, Khalid MD, Muhammad UK, Farida HK, Fahmida K, et al. Changes in complacency to adherence to COVID-19 preventive behavioral measures and mental health after COVID-19 vaccination among medical and dental healthcare professionals. Hum Vaccin Immunother. 2024;20(1):2369358. DOI: https://doi.org/10.1080/21645515.2024.2369358

He X, He C, Hong W, Zhang K, Wei X. The challenges of COVID‐19 Delta variant: Prevention and vaccine development. Med Comm (Beijing). 2021;2(4):846-54. DOI: https://doi.org/10.1002/mco2.95

Ali AS, Yohannes MW, Tesfahun T. Hygiene Behavior and COVID-19 Pandemic: Opportunities of COVID-19-Imposed Changes in Hygiene Behavior. J Health Care Org Provision Financing. 2023;60. DOI: https://doi.org/10.1177/00469580231218421

Ferreira Caceres MM, Sosa JP, Lawrence JA. The impact of misinformation on the COVID-19 pandemic. AIMS Public Health. 2022;9(2):262-77. DOI: https://doi.org/10.3934/publichealth.2022018

Annenberg Public Policy Center of the University of Pennsylvania. New APPC Survey Finds Belief in COVID-19 Vaccination Misinformation Has Grown. 2024. Available at: https://www.asc.upenn.edu/news-events/news/new-appc-survey-finds-belief-covid-19-vaccination-misinformation-has-grown. Accessed on 13 September 2025.

Shang W, Kang L, Cao G, Yaping W, Peng G, Jue L, et al. Percentage of Asymptomatic Infections among SARS-CoV-2 Omicron Variant-Positive Individuals: A Systematic Review and Meta-Analysis. Vaccines (Basel). 2022;10(7):1049. DOI: https://doi.org/10.3390/vaccines10071049

Ma Q, Liu J, Liu Q, Liangyu K, Runqing L, Wenzhan J, et al. Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals with Confirmed COVID-19 Diagnosis: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(12):e2137257. DOI: https://doi.org/10.1001/jamanetworkopen.2021.37257

Cleveland Clininc. What is an mRNA vaccine? 2024. Available at: https://my.clevelandclinic.org/health/treatments/21898-mrna-vaccines. Accessed on 13 September 2025.

Shrestha NK, Burke PC, Nowacki AS, Gordon SM. Effectiveness of the 2023-2024 Formulation of the COVID-19 Messenger RNA Vaccine. Clinical Infectious Diseases. 2024;79(2):405-11. DOI: https://doi.org/10.1093/cid/ciae132

Deng S, Liang H, Chen P, Yuwan L, Zhaoyao L, Shuangqi F, et al. Viral Vector Vaccine Development and Application during the COVID-19 Pandemic. Microorganisms. 2022;10(7):1450. DOI: https://doi.org/10.3390/microorganisms10071450

WHO. COVID-19 Vaccine (Vero Cell), Inactivated (Sinopharm). 2021. Available at: https://cdn.who.int/media/docs/default-source/immunization/covid-19/16-june-22080-sinopharm-vaccine-explainer-update.pdf. Accessed on 13 September 2025.

Pooley N, Abdool Karim SS, Combadière B, Eng EO, Rebecca CH, Clotilde El GS, et al. Durability of Vaccine-Induced and Natural Immunity Against COVID-19: A Narrative Review. Infect Dis Ther. 2023;12(2):367-87. DOI: https://doi.org/10.1007/s40121-022-00753-2

Tatar M, Shoorekchali JM, Faraji MR, Seyyedkolaee MA, Pagán JA, Wilson FA. COVID-19 vaccine inequality: A global perspective. J Glob Health. 2022;12:03072. DOI: https://doi.org/10.7189/jogh.12.03072

Carlin PR, Minard P, Simon DH, Wing C. Effects of large gatherings on the COVID-19 epidemic: Evidence from professional and college sports. Econ Hum Biol. 2021;43:101033. DOI: https://doi.org/10.1016/j.ehb.2021.101033

Yan VKC, Wan EYF, Ye X, Anna HYM, Francisco TTL, Celine SLC, et al. Waning effectiveness against COVID-19-related hospitalization, severe complications, and mortality with two to three doses of CoronaVac and BNT162b2: a case-control study. Emerg Microbes Infect. 2023;12(1):2209201. DOI: https://doi.org/10.1080/22221751.2023.2209201

Saravanan KA, Panigrahi M, Kumar H, Divya R, Sonali SN, Bharat B, et al. Role of genomics in combating COVID-19 pandemic. Gene. 2022;823:146387. DOI: https://doi.org/10.1016/j.gene.2022.146387

Bergquist S, Otten T, Sarich N. COVID-19 pandemic in the United States. Health Policy Technol. 2020;9(4):623-38. DOI: https://doi.org/10.1016/j.hlpt.2020.08.007

Dhar R, Pethusamy K, Jee B, Karmakar S. Fault Lines in India’s COVID-19 Management: Lessons Learned and Future Recommendations. Risk Manag Healthc Policy. 2021;14:4379-92. DOI: https://doi.org/10.2147/RMHP.S320880

Liu LS, Ran GJ, Jia X. New Zealand border restrictions amidst COVID-19 and their impacts on temporary migrant workers. Asian Pacific Migration J. 2022;31(3):312-23. DOI: https://doi.org/10.1177/01171968221126206

Downloads

Published

2025-11-29

How to Cite

Sinha, I., & Pandey , A. (2025). COVID-19 and its resurgence, public behavior, and global response: lessons learnt. International Journal Of Community Medicine And Public Health, 12(12), 5820–5826. https://doi.org/10.18203/2394-6040.ijcmph20254066

Issue

Section

Review Articles