Efficacy of Artocarpus heterophyllus leaf extract mouthwash in gingivitis subjects: a clinico microbiological study
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20253262Keywords:
Gingivitis, Non-surgical periodontal therapy, Plaque samples, Porphyromonas gingivalis, Artocarpus heterophyllusAbstract
Background: Gingivitis is the inflammatory disease of gingiva that supports the teeth. The prevailing belief regarding the cause of gingivitis is the toxins produced by anaerobic bacteria in oral cavity particularly that cause the formation of plaque. The tropical climacteric fruit Artocarpus heterophyllus, commonly known as jackfruit possess anti carcinogenic, antimicrobial, antifungal, anti-inflammatory, wound-healing and hypoglycaemic properties. Hence the objective of this study is to evaluate clinical parameters at baseline and 21 days post non-surgical periodontal therapy after the use of jackfruit leaf extract mouthwash and to evaluate the colony count of P. gingivalis in plaque samples at baseline and 21 days after the use of jackfruit leaf extract mouthwash.
Methods: A total of 30 gingivitis subjects were selected and divided randomly into group A and B. Group 1, non-surgical periodontal therapy alone (15). Group 2, non-surgical periodontal therapy followed by jackfruit leaf extract mouthwash (15). The supra gingival plaque samples were collected from both the groups at baseline and 21 days post non-surgical periodontal therapy.
Results: Significant reduction in clinical parameters and colony count of P. gingivalis after the use of Artocarpus heterophyllus mouthwash.
Conclusions: Jackfruit leaf extract mouthwash has better promising effect on inflammation in gingivitis subjects when compared to gingivitis subjects with non-surgical periodontal therapy alone.
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References
Rathee M, Jain P. Gingivitis. In StatPearls. Stat Pearls Publishing. 2022.
Volman EI, Stellrecht E, Scannapieco FA. Proven Primary Prevention Strategies for Plaque-Induced Periodontal Disease-An Umbrella Review. J Int Academy of Periodontol. 2021;23(4):350-67.
Liu X, Xu J, Li S, Wang X, Liu J, Li X. The prevalence of gingivitis and related risk factors in schoolchildren aged 6-12 years old. BMC oral health. 2022;22(1):623. DOI: https://doi.org/10.1186/s12903-022-02670-9
Deus FP, Ouanounou A. Chlorhexidine in dentistry: pharmacology, uses, and adverse effects. Int Dental J 2022;72(3):269-77. DOI: https://doi.org/10.1016/j.identj.2022.01.005
Ranasinghe RA, Maduwanthi SD, Marapana RA. Nutritional and health benefits of jackfruit (Artocarpus heterophyllus Lam.): a review. Int J Food Sci. 2019;2019(1):4327183. DOI: https://doi.org/10.1155/2019/4327183
Augustina EF, Bargowo L, Anhar A, Aini DN. Inhibitory activity of jackfruit (Atrocarpus heterophyllus Lam.) leaf extract on the growth of Porphyromonas gingivalis bacteria. World J Adv Res Rev. 2023;17(1):126-32. DOI: https://doi.org/10.30574/wjarr.2023.17.1.0006
Rantika N, Sriarumtias FF, Fadilah M. Formulation and Antibacterial Activity of Mouthwash From Ethanol Leaf Extract of Breadfruit (Artocaprus altilis (Parkinson) Forsbeg). J Ilmiah Farmako Bahari. 2019;10(1):65-75. DOI: https://doi.org/10.52434/jfb.v10i1.649
Koregol AC, Kalburgi NB, Puttarevanna T, Patil RS, Singh P, Sulakod K. Antimicrobial efficacy of grape seed extract in terminating the ramifications of plaque microorganisms: A randomized control study. Med Pharmacy Reps. 2022;95(2):185. DOI: https://doi.org/10.15386/mpr-1978
Kumar SB. Chlorhexidine mouthwash-a review. J Pharmaceut Sci Res. 2017;9(9):1450.
Grossman E, Reiter G, Sturzenberger OP, De La Rosa M, Dickinson TD, Flrretti GA, et al. Six‐month study of the effects of a chlorhexidine mouthrinse on gingivitis in adults. J Periodontal Res. 1986;21(16):33-43. DOI: https://doi.org/10.1111/j.1600-0765.1986.tb01513.x
Ahmad M, Parichehr B, Naeimeh N, Pedram I, Seyed A, Jaber Y. Comparison of the efficacy and side effects of chlorhexidine mouthrinses with (Hexidine) and without (Epimax) alcohol. Dent Hypotheses. 2016;7(4):137-41. DOI: https://doi.org/10.4103/2155-8213.195971
Khan AU, Ema IJ, Faruk MR, Tarapder SA, Khan AU, Noreen S, Adnan M. A review on importance of Artocarpus heterophyllus L. (Jackfruit). J Multidisciplinary Applied Natural Sci. 2021;1(2):106-16. DOI: https://doi.org/10.47352/jmans.v1i2.88
Bhat N, Mitra R, Oza S, Mantu VK, Bishnoi S, Gohil M, et al. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial. J Complementary Integrat Med. 2014;11(2):129-37. DOI: https://doi.org/10.1515/jcim-2014-0002
Prakash A, Savita, Nahyan N, Adarsh NG, Maesarah M. Jackfruit Leaf Extract Hydrogel as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis-A Randomised Controlled Trial. J Chem Health Risks. 2024;14(3):2182-7.
Kalburgi NB, Koregol AC, Roy A, Sultana UP. Evaluation of Antimicrobial Efficacy of 5% Myristica Fragrans Mouthwash in Gingivitis Subjects-A Clinico Microbiological Study. Int J Ayurveda Pharma Res. 2024;15(5):1-7. DOI: https://doi.org/10.47070/ijapr.v12i5.3201
Gupta KR, Devanand G, John BD, Ankit Y, Khursheed O, Sumit M. Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial. Ethiop J Health Sci. 2014;24(2):139-44. DOI: https://doi.org/10.4314/ejhs.v24i2.6
Prasad KR, John S, Deepika V, Dwijendra KS, Reddy BR, Chincholi S. Anti-plaque efficacy of herbal and 0.2% chlorhexidine gluconate mouthwash: A comparative study. J Int Oral Health. 2015;7(8):98.
Vaish S, Ahuja S, Dodwad V, Parkash H. Comparative evaluation of 0.2% chlorhexidine versus herbal oral rinse on plaque induced gingivitis. J Indian Assoc Publ Health Dentistr. 2012;10(19):55-62. DOI: https://doi.org/10.4103/2319-5932.167734
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