Ketamine infusion therapy in an elderly patient with complex regional pain syndrome and major depression

Authors

  • Parinda Parikh Department of Psychiatry, Weill Cornell Medical School, White Plains, New York, USA
  • Jeremy Kays Windsor University School of Medicine, St. Kitts, West Indies
  • Zoe Gellert Tulane University, New York, USA
  • Shaurya K. Singh Pravara Institute of Medical Sciences, Loni, Maharashtra, India
  • Alisha A. Alphonse St. George’s University, Grenada, West Indies
  • Himani J. Suthar GMERS Medical College and Civil Hospital, Gandhinagar, Gujarat, India
  • Aatish D. Bhatta KIST Medical College and Teaching Hospital, Lalitpur, Nepal
  • Arnesh Shukla St. Martinus University, Willemstad, Curacao
  • Parthiv Pansuriya Government Medical College, Surat, Gujarat, India
  • Arushi K. Chandra New York University, New York, USA
  • Mahiya Buddhavarapu University of Pittsburgh, Pennsylvania, USA
  • Mina Oza 2ND ARC Associates, White Plains, New York, USA

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20252868

Keywords:

Complex regional pain syndrome, Ketamine infusion, Major depression, Chronic pain, Elderly patient, Culturally sensitive care

Abstract

Complex regional pain syndrome (CRPS) is a chronic pain disorder that severely affects mobility and quality of life. This case report describes an 86-year-old man who has a long-standing history of CRPS-related back and leg pain. Traditional treatments, including opioids and duloxetine, did not improve his symptoms, and due to religious beliefs restricting specific interventions, standard hospital care was limited. Given the severity of his symptoms and the refractory nature of his condition, an intravenous ketamine infusion was recommended to improve pain and comorbid depressive symptoms. Following one treatment, the patient exhibited immediate and substantial improvements in pain intensity, mood, and mobility. This case accentuates the importance of culturally sensitive, patient-centered care and suggests the role of ketamine in treating CRPS when traditional therapies are ineffective.

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Author Biographies

Parinda Parikh, Department of Psychiatry, Weill Cornell Medical School, White Plains, New York, USA

Dr. Parinda Parikh

Corresponding Author

Department of Psychiatry

Weill Cornell Medical School

White Plains, New York, USA

Jeremy Kays, Windsor University School of Medicine, St. Kitts, West Indies

First Author

References

Goldberg ME, Torjman MC, Schwartzman RJ, Mager DE, Wainer I. Pharmacodynamic profiles of ketamine (R-) and (S+) with five-day inpatient infusion for the treatment of complex regional pain syndrome. Pain Physician. 2010;13(4):379-87. DOI: https://doi.org/10.36076/ppj.2010/13/379

Sleigh J, Harvey M, Voss L, Denny B. Ketamine – more mechanisms of action than just NMDA blockade. Trends Anaesth Crit Care. 2014;4(2-3):76-81. DOI: https://doi.org/10.1016/j.tacc.2014.03.002

Collingridge GL, Bliss TV. NMDA receptors: their role in long-term potentiation. Trends Neurosci. 1987;10(7):288-93. DOI: https://doi.org/10.1016/0166-2236(87)90175-5

Ruoff GE. Depression in the patient with chronic pain. J Fam Pract. 1996;43(6):S25-31.

Stahl SM, Briley M. Understanding pain in depression. Hum Psychopharmacol. 2004;19(S1):S9-13. DOI: https://doi.org/10.1002/hup.619

Von Korff M, Simon G. The relationship between pain and depression. Br J Psychiatry. 1996;168(30):101-8. DOI: https://doi.org/10.1192/S0007125000298474

Surah A, Baranidharan G, Morley S. Chronic pain and depression. Contin Educ Anaesth Crit Care Pain. 2014;14(2):85-9. DOI: https://doi.org/10.1093/bjaceaccp/mkt046

Bair MJ, Robinson RL, Katon W, Kroenke K. Depression and pain comorbidity: a literature review. Arch Intern Med. 2003;163(20):2433-45. DOI: https://doi.org/10.1001/archinte.163.20.2433

Schwartzman RJ, Alexander GM, Grothusen JR, Paylor T, Reichenberger E, Perreault M. Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo-controlled study. Pain. 2009;147(1-3):107-15. DOI: https://doi.org/10.1016/j.pain.2009.08.015

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Published

2025-08-30

How to Cite

Parikh, P., Kays, J., Gellert, Z., K. Singh, S., A. Alphonse, A., J. Suthar, H., D. Bhatta, A., Shukla, A., Pansuriya, P., K. Chandra, A., Buddhavarapu, M., & Oza, M. (2025). Ketamine infusion therapy in an elderly patient with complex regional pain syndrome and major depression. International Journal Of Community Medicine And Public Health, 12(9), 4162–4164. https://doi.org/10.18203/2394-6040.ijcmph20252868

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Section

Case Reports