A study on gamma-glutamyl transferase and C-reactive protein levels in type 2 diabetes mellitus patients and their correlation with glycosylated hemoglobin levels

Allareddy Sathvika; Uma M. Anand Kumar; Harish Kumar S.; Kotthinti A. Kumar

doi:10.18203/2394-6040.ijcmph20252478

Authors

Allareddy Sathvika Department of General Medicine, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India https://orcid.org/0009-0000-9138-6014
Uma M. Anand Kumar Department of General Medicine, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India
Harish Kumar S. Department of General Medicine, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India
Kotthinti A. Kumar Department of General Medicine, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20252478

Keywords:

Type 2 diabetes mellitus, Gamma-glutamyl transferase, C-reactive protein, HbA1c

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a growing global health concern. Oxidative stress and chronic inflammation have been implicated in its pathophysiology. Gamma-glutamyl transferase (GGT) and C-reactive protein (CRP) are potential biomarkers associated with glycemic control. This study aims to estimate serum GGT, CRP, and glycated hemoglobin (HbA1c) levels in T2DM patients and evaluate their correlation. Aims and objectives of the study were to assess the serum levels of GGT and CRP in T2DM patients and analyze their correlation with HbA1c.

Methods: A cross-sectional observational study was conducted on 93 T2DM patients at P.E.S. Medical College Hospital, Kuppam. Patients underwent testing for serum GGT, CRP, and HbA1c. Data were analyzed using statistical package for the social sciences (SPSS) v26. Correlation between GGT, CRP, and HbA1c was evaluated using Pearson’s correlation, with p<0.05 considered statistically significant.

Results: The mean age of participants was 59.34±10.7 years; 67.7% were male. Mean GGT, CRP, and HbA1c levels were 41.51±24.8 mg/dl, 11.14±11.4 mg/dl, and 7.83±1.59 mmol/l, respectively. A strong positive correlation was found between serum GGT and HbA1c (r=0.900, p<0.001), and a weaker but significant correlation between CRP and HbA1c (r=0.047, p=0.030).

Conclusions: Elevated serum GGT and CRP levels were observed in T2DM patients. GGT showed a strong positive correlation with HbA1c, suggesting its utility as a marker of oxidative stress and glycemic control. CRP also correlated significantly, indicating a role for inflammation in diabetes progression.

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