Epidemiological risk factors associated with infertility
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20251737Keywords:
Infertility, Epidemiological risk factors, Sterility, Public health problemAbstract
Infertility is a serious and stigmatic health issue especially in a country like India. On one side India is dealing with population overgrowth and limited resources while on other side problem of infertility haunts many reproductive age group couples. According to world health organisation (WHO), one in every fourth couple in the developing country is suffering from infertility. The globally prevalence of infertility is 10-15%. Infertility can be primary or secondary. Male or female factors or both can cause infertility. Prevalence of infertility varies with diversity in the customs, traditions, climatic condition and health status. In addition, prevalence of infertility is increasing due to depression, anxiety, stress, and other physiological conditions. Few preventable conditions such as infection, lifestyle factors, advancing maternal age, age at marriage, postponement in child bearing for more than 1 year or more, socio-economic status, and occupational hazards also predispose to infertility. The main challenge of infertility is to estimate the actual prevalence of infertility due to varying definitions of infertility. The magnitude of the problem calls for urgent action, particularly when in the majority of cases the infertility is avoidable.
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References
Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod. 2007;22(6):1506-12.
Tao X, Ge SQ, Chen L, Cai LS, Hwang MF, Wang CL. Relationships between female infertility and female genital infections and pelvic inflammatory disease: a population-based nested controlled study. Clinics. 2018;73:e364. DOI: https://doi.org/10.6061/clinics/2018/e364
Deyhoul N, Mohamaddoost T, Hosseini M. Infertility-related risk factors: a systematic review. Int J Women's Health Reprod Sci. 2017;5(1):24-9. DOI: https://doi.org/10.15296/ijwhr.2017.05
Ombelet W. WHO fact sheet on infertility gives hope to millions of infertile couples worldwide. Facts Views Vision ObGyn. 2020;12(4):249-51.
Cox CM, Thoma ME, Tchangalova N, Mburu G, Bornstein MJ, Johnson CL, et al. Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis. Human Reproduct Open. 2022;2022(4):hoac051. DOI: https://doi.org/10.1093/hropen/hoac051
Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, Regional, and Global Trends in Infertility Prevalence since 1990: A Systematic Analysis of 277 Health Surveys. PLoS Med. 2012;9:e1001356. DOI: https://doi.org/10.1371/journal.pmed.1001356
Azize Diallo A, Anku PJ, Darkoa Oduro RA. Exploring the psycho-social burden of infertility: Perspectives of infertile couples in Cape Coast, Ghana. PLoS ONE. 2024;19(1):e0297428. DOI: https://doi.org/10.1371/journal.pone.0297428
Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary on ART terminology, 2009. Hum Reprod. 2009;24(11):2683-7. DOI: https://doi.org/10.1093/humrep/dep343
World Health Organization. Reproductive health indicators for global monitoring: guidelines for their generation, interpretation and analysis for global monitoring (online). Geneva: World Health Organization. 2006. Available at: apps.who.int/iris/bitstream/10665/43185/1/1924156315X_eng.pdf. Accessed on 15 January 2025.
Rowe PJ, Comhaire FH, Hargreave TB, Mellows HJ, Press CU. WHO manual for the standardized investigation and diagnosis of the infertile couple (online). Cambridge: Cambridge University. 1993. Available at: catdir.loc.gov/catdir/sample/cam033/ 2001025538.pdf Accessed on 15 January 2025.
Kumar D. Tribal literacy disparity in India. Current Sci. 2005;88:676.
Human genetics fertilization and Tissue commission. HFEA-Directory of Clinics, Guide to Infertility (online). UK:2003/04. Available at: www.hfea.gov.uk/doc/GUIDE_2003-04pgf. Accessed on 15 January 2025.
Velde ER. Variation in couple fecundity and time to pregnancy an essential concept in human reproduction. Lancet. 2000;355(9219):1928-29. DOI: https://doi.org/10.1016/S0140-6736(00)02320-5
Bongaarts J. A method for the estimation of fecundability. Demography. 1975;12(4):645-60. DOI: https://doi.org/10.2307/2060719
Schwartz D, Mayaux MJ. Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. Federation CECOS. N Engl J Med. 1982;306(7):404-6. DOI: https://doi.org/10.1056/NEJM198202183060706
Zaadstra NBM, Looman CW, Alsbach H, Habbema JD, Te Velde ER, Karbaat J. Delaying child bearing: effect of age on fecundity and outcome of pregnancy. BMJ 1991;302(6789):1361-5. DOI: https://doi.org/10.1136/bmj.302.6789.1361
Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment seeking: potential need and demand for infertility medical care. Hum Reprod. 2007;22(6):1506-12. DOI: https://doi.org/10.1093/humrep/dem046
Sundby J, Mboge R, Sonko S. Infertility in the Gambia: frequency and health care seeking. Soc Sci Med. 1998;46(7):891-9. DOI: https://doi.org/10.1016/S0277-9536(97)00215-3
Geelhoed DW, Nayembil D, Asare K, SchagenvanLeeuwen JH, Roosmalen J. Infertility in rural Ghana. Int J Gynaecol Obstet. 2002;79(2):137-42. DOI: https://doi.org/10.1016/S0020-7292(02)00237-0
Haile A. Fertility conditions in Gondar, northwestern Ethiopia: an appraisal of current status. Stud Fam Plann. 1990;21:110-8. DOI: https://doi.org/10.2307/1966672
Ebomoyi E, Adetoro O. Socio-biological factors influencing infertility in a rural Nigerian community. Int J Gynaecol Obstet. 1990;33(1):41-7. DOI: https://doi.org/10.1016/0020-7292(90)90653-3
Adetoro OO, Ebomoyi EW. The prevalence of infertility in a rural Nigerian community. Afr J Med Sci. 1991;20(1):23-7.
Okonofua FE. The case against new reproductive technologies in developing countries. Br J Obstet Gynaec. 1996;103(10):957-62. DOI: https://doi.org/10.1111/j.1471-0528.1996.tb09542.x
World Health Organization. Infertility: A Tabulation of Available Data on Prevalence of Primary and Secondary Infertility. Geneva: WHO. 1991. Available at: https://iris.who.int/handle/10665/59769. Accessed on 15 January 2025.
Calverton RM. Infecundity, infertility, and childlessness in developing countries. DHS Comparative Reports No 9 (Online). World Health Organization USA. 2004. Available at: www.who.int/reproductivehealth/topics/infertility/ DHS_CRG.pgf. Accessed on 15 January 2025.
Talwar PP, Go OP, Murali IN. Statistics and demography. New Delhi: National Institute of Health and Family Welfare and Indian Council of Medical Research; 1986. Prevalence of infertility in different population groups in India and its determinants. 1986.
Unisa S. Childlessness in Andhra Pradesh, India: Treatment-seeking and consequences. Reprod Health Matters. 1999;7:54-64. DOI: https://doi.org/10.1016/S0968-8080(99)90112-X
Zargar AH, Wani AI, Masoodi SR, Laway BA, Salahuddin M. Epidemiologic and etiologic aspects of primary infertility in the Kashmir region of India. Fertil Steril. 1997;68(4):637-43. DOI: https://doi.org/10.1016/S0015-0282(97)00269-0
Kumar D. Prevalence of female infertility and its socio-economic factors in tribal communities of Central India. Rural Remote Health. 2007;7(2):456. DOI: https://doi.org/10.22605/RRH456
Kanal P, Sharma S. Study of Primary Infertility in females by Diagnostic Laparoscopy. Internet J Med Update. 2006;1(2):7-9. DOI: https://doi.org/10.4314/ijmu.v1i2.39834
Walker U, Hofler W. Prevalence of Chlamydia trachomatis in pregnant women and infertility cases in Abeokuta, Nigeria. Trop Med Parasit. 1989;40(1):77-81.
Sciarra JJ. Sexually transmitted diseases: global importance. Int J Gynaecol Obstet. 1997;58(1):107-19. DOI: https://doi.org/10.1016/S0020-7292(97)02867-1
Vayena E, Rowe PJ, Griffin PD. Current Practices and Controversies in Assisted Reproduction in developing countries with particular reference to sub-Saharan Africa. Geneva, Switzerland: World Health Organization. 2002;22-7.
Adler MW. Sexually transmitted diseases control in developing countries. Genitourin Med. 1996;72(2):83-8. DOI: https://doi.org/10.1136/sti.72.2.83
Bambra CS. Current status of reproductive behavior in Africa. Hum Report Update. 1999;5(1):1-20. DOI: https://doi.org/10.1093/humupd/5.1.1
NA. Infections, pregnancies and infertility: perspectives on prevention. Fertil Steril. 1987;47:944-9. DOI: https://doi.org/10.1016/S0015-0282(16)59230-9
Nachtigall RD. International disparities in access to infertility services. Fertil Steril 2006; 85:871-875. DOI: https://doi.org/10.1016/j.fertnstert.2005.08.066
Malpani A, Malpani A. Simplifying assisted conception techniques to make them universally available-a view from India. Hum Reprod. 1992;7(1):49-50. DOI: https://doi.org/10.1093/oxfordjournals.humrep.a137555
Van Balen F, Gerrits T. Quality of infertility care in poor-resource areas and the introduction of new reproductive technologies. Hum Reprod. 2001;16(2):215-9. DOI: https://doi.org/10.1093/humrep/16.2.215
Dyer SJ, Abrahams N, Hoffman M, van der Spuy ZM. ‘Men leave me as I cannot have children’: women's experiences with involuntary childlessness. Hum Reprod. 2002;17(6):1663-8. DOI: https://doi.org/10.1093/humrep/17.6.1663
Dyer SJ, Abrahams N, Hoffman M, van der Spuy ZM. Infertility in South Africa: women's reproductive health knowledge and treatment-seeking behavior for involuntary childlessness. Hum Reprod. 2002;17(6):1657-62. DOI: https://doi.org/10.1093/humrep/17.6.1657
Fathalla MF, Vayena E, Rowe PJ, Griffin PD. Current challenges in assisted reproduction and Current Practices and Controversies in Assisted Reproduction. Geneva, Switzerland: World Health Organization. 2002;3-12.
Vayena E, Rowe JP, Peterson HB. Assisted-reproductive technology in developing countries: why should we care? Fertil Steril. 2002;78(1):13-5. DOI: https://doi.org/10.1016/S0015-0282(02)03177-1
Ried K, Alfred A. Quality of life, coping strategies and support needs of women seeking Traditional Chinese Medicine for infertility and viable pregnancy in Australia: a mixed methods approach. BMC Women’s Health. 2013;13:17. DOI: https://doi.org/10.1186/1472-6874-13-17
Lansakara N, Wickramasinghe AR, Seneviratne HR. Feeling the blues of infertility in South Asian contex: psychological wellbeing and associated factors amongSri Lankan women with primary infertility. Women Health. 2011;51(4):383-99. DOI: https://doi.org/10.1080/03630242.2011.574790