Helicobacter pylori and chronic kidney disease: controversy and possibility

Authors

  • Abdullah M. Nasrat Department of Surgery and Research, Zaitona Medical Center, Medina, Saudi Arabia
  • Faisal F. Alhamad College of Medicine, Al-Rayan Colleges, Al-Madinah Al-Munawwara, Saudi Arabia
  • Ali Z. A. M. Alshammari College of Medicine, Al-Rayan Colleges, Al-Madinah Al-Munawwara, Saudi Arabia
  • Zayed M. Alnefaie Department of Anatomy and Embryology, Al-Rayan Colleges, Al-Madinah Al-Munawwara, Saudi Arabia
  • Yousef M. Alsaedi College of Medicine, Al-Rayan Colleges, Al-Madinah Al-Munawwara, Saudi Arabia
  • Nafesa M. Alshammari College of Medicine, Al-Rayan Colleges, Al-Madinah Al-Munawwara, Saudi Arabia
  • Hassan A. A. Ahmed Department of Urology, Al Hayat National Hospital, Medina, Saudi Arabia
  • Ibrahim S. Aljohani College of Medicine, Al-Rayan Colleges, Al-Madinah Al-Munawwara, Saudi Arabia

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20250015

Keywords:

Chronic kidney disease, Colon clear, Helicobacter pylori, Haemodialysis

Abstract

Chronic kidney disease (CKD) is rapidly increasing worldwide, constituting a major public health burden that will stress healthcare systems in all countries, with end-stage renal disease (ESRD) emerging as a growing challenge, particularly in developing nations. The increasing burden of CKD, coupled with limited financial and epidemiological resources in less developed countries, places a severe strain on existing health policies. Hypertensive illness and diabetes mellitus (DM) are significant predisposing risk factors for the development and progression of chronic kidney disease. However, the literature lacks sufficient knowledge about the influence of Helicobacter pylori on chronic kidney disease, and while there is controversy surrounding the association of H. pylori with DM and hypertension, current knowledge does not support a direct role of H. pylori in causing CKD. This prospective case series, conducted in Medina, Saudi Arabia, from October 2023 to October 2024, involved nine patients with varying grades of renal dysfunction associated with the presence of H. pylori, which was confirmed through specific tests; colon clearing was performed on all patients. The results indicated a marked improvement in kidney function, highlighted by decreased blood urea and serum creatinine levels. Consequently, colonic H. pylori strains could be a hidden contributor to CKD through toxic or immune mechanisms, suggesting that careful attention to colonic health may be crucial for individuals with impaired kidney function associated with H. pylori existence.

Metrics

Metrics Loading ...

References

Lou-Meda R. Prevention of CKD in Guatemala. Clin Nephrol. 2010;74(1):S126-8. DOI: https://doi.org/10.5414/CNP74S126

Cueto-Manzano AM, Martínez-Ramírez HR, Cortés-Sanabria L. Management of chronic kidney disease: primary health-care setting, self-care and multidisciplinary approach. Clin Nephrol. 2010;74(1):S99-104. DOI: https://doi.org/10.5414/CNP74S099

Rajapurkar M, Dabhi M. Burden of disease - prevalence and incidence of renal disease in India. Clin Nephrol. 2010;74(1):S9-12. DOI: https://doi.org/10.5414/CNP74S009

Satirapoj B, Supasyndh O, Mayteedol N, Chaiprasert A, Choovichian P. Metabolic syndrome and its relation to chronic kidney disease in a Southeast Asian population. Southeast Asian J Trop Med Public Health 2011;42(1):176-83.

Ruan X, Guan Y. Metabolic syndrome and chronic kidney disease. J Diabetes. 2009;1(4):236-45. DOI: https://doi.org/10.1111/j.1753-0407.2009.00042.x

Shaheen FA, Souqiyyeh MZ. Kidney health in the Middle East. Clin Nephrol. 2010;74(1):S85-8. DOI: https://doi.org/10.5414/CNP74S085

Liaño F, Tenorio MT, Rodríguez-Mendiola N, Ponte B. Acute kidney injury as a risk factor for chronic kidney diseases in disadvantaged populations. Clin Nephrol. 2010;74(1):S89-94. DOI: https://doi.org/10.5414/CNP74S089

Farinha P, Gascoyne RD. Helicobacter pylori and MALT Lymphoma. Gastroenterology. 2005;128(6):1579-605. DOI: https://doi.org/10.1053/j.gastro.2005.03.083

Sugimoto M, Yamaoka Y. Review of Helicobacter pylori infection and chronic renal failure. Ther Apher Dial. 2011;15(1):1-9. DOI: https://doi.org/10.1111/j.1744-9987.2010.00851.x

Baradaran A, Nasri H. Helicobacter pylori specific IgG antibody and serum magnesium in type-2 diabetes mellitus chronic kidney disease patients. Saudi J Kidney Dis Transpl. 2011;22(2):282-5.

Nasrat AM, Nasrat SAM, Nasrat RM, Nasrat MM. Misconception and misbehavior towards Helicobacter pylori is leading to major spread of illness. Gen Med. 2015;S1:002. DOI: https://doi.org/10.4172/2327-5146.1000S1-002

Hooman N, Mehrazma M, Talachian E, Otukesh H, Nakhaii S. Helicobacter pylori infection in pediatric candidates for kidney transplantation. Iran J Kidney Dis. 2011;5(2):124-9.

Auron A, Brophy PD. Hyperammonemia in review: pathophysiology, diagnosis, and treatment. Pediatr Nephrol. 2012;27(2):207-22. DOI: https://doi.org/10.1007/s00467-011-1838-5

Nasrat AM, Nasrat SAM, Nasrat RM, Nasrat MM, Nasrat AM. An alternate natural remedy for symptomatic relief of Helicobacter pylori dyspepsia. Gen Med. 2015;3(4). DOI: https://doi.org/10.4172/2327-5146.1000200

Downloads

Published

2025-01-10

How to Cite

Nasrat, A. M., Alhamad, F. F., Alshammari, A. Z. A. M., Alnefaie, Z. M., Alsaedi, Y. M., Alshammari, N. M., Ahmed, H. A. A., & Aljohani, I. S. (2025). Helicobacter pylori and chronic kidney disease: controversy and possibility. International Journal Of Community Medicine And Public Health, 12(2), 934–938. https://doi.org/10.18203/2394-6040.ijcmph20250015

Issue

Section

Case Series